Keiyo Takubo

J-GLOBAL         Last updated: Dec 2, 2019 at 17:27
 
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Name
Keiyo Takubo
Affiliation
National Center for Global Health and Medicine
Section
Department of Stem Cell Biology
Job title
Project director

Research Areas

 
 

Academic & Professional Experience

 
Apr 2014
 - 
Today
Project director, Research Institute, National Institute for Global Health and Medicine
 
Nov 2011
 - 
Mar 2015
Senior assistant professor, School of Medicine, Keio University
 
Apr 2008
 - 
Oct 2011
Assistant professor, School of Medicine, Keio University
 
Apr 2006
 - 
Mar 2008
Research fellow, The Japan Society for the Promotion of Science
 

Published Papers

 
Tsuchiya N, Zhang R, Iwama T, Ueda N, Liu T, Tatsumi M, Sasaki Y, Shimoda R, Osako Y, Sawada Y, Kubo Y, Miyashita A, Fukushima S, Cheng Z, Nakaki R, Takubo K, Okada S, Kaneko S, Ihn H, Kaisho T, Nishimura Y, Senju S, Endo I, Nakatsura T, Uemura Y
Cell reports   29(1) 162-175.e9   Oct 2019   [Refereed]
Nagai M, Noguchi R, Takahashi D, Morikawa T, Koshida K, Komiyama S, Ishihara N, Yamada T, Kawamura YI, Muroi K, Hattori K, Kobayashi N, Fujimura Y, Hirota M, Matsumoto R, Aoki R, Tamura-Nakano M, Sugiyama M, Katakai T, Sato S, Takubo K, Dohi T, Hase K
Cell   178(5) 1072-1087.e14   Aug 2019   [Refereed]
Kobayashi H, Morikawa T, Okinaga A, Hamano F, Hashidate-Yoshida T, Watanuki S, Hishikawa D, Shindou H, Arai F, Kabe Y, Suematsu M, Shimizu T, Takubo K
Cell reports   28(1) 145-158.e9   Jul 2019   [Refereed]
Watanuki S, Kobayashi H, Sorimachi Y, Yamamoto M, Okamoto S, Takubo K
Biochemical and biophysical research communications   514(1) 287-294   Jun 2019   [Refereed]
Mima Y, Suzuki S, Fujii T, Morikawa T, Tamaki S, Takubo K, Shimoda M, Miyamoto T, Watanabe K, Matsumoto M, Nakamura M, Fujita N
Journal of orthopaedic research : official publication of the Orthopaedic Research Society   37(4) 972-980   Apr 2019   [Refereed]
Goto S, Morikawa T, Kubo A, Takubo K, Fukuda K, Kajimura M, Suematsu M
Journal of clinical biochemistry and nutrition   63(1) 70-79   Jul 2018   [Refereed]
Baba M, Endoh M, Ma W, Toyama H, Hirayama A, Nishikawa K, Takubo K, Hano H, Hasumi H, Umemoto T, Hashimoto M, Irie N, Esumi C, Kataoka M, Nakagata N, Soga T, Yao M, Kamba T, Minami T, Ishii M, Suda T
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research      Jun 2018   [Refereed]
Shiota M, Naya M, Yamamoto T, Hishiki T, Tani T, Takahashi H, Kubo A, Koike D, Itoh M, Ohmura M, Kabe Y, Sugiura Y, Hiraoka N, Morikawa T, Takubo K, Suina K, Nagashima H, Sampetrean O, Nagano O, Saya H, Yamazoe S, Watanabe H, Suematsu M
Nature communications   9(1) 1561   Apr 2018   [Refereed]
Si S, Nakajima-Takagi Y, Iga T, Tsuji M, Hou L, Oshima M, Koide S, Saraya A, Yamazaki S, Takubo K, Kubota Y, Minamino T, Iwama A
Experimental hematology   63 41-51.e1   Apr 2018   [Refereed]
Iizuka-Hishikawa Y, Hishikawa D, Sasaki J, Takubo K, Goto M, Nagata K, Nakanishi H, Shindou H, Okamura T, Ito C, Toshimori K, Sasaki T, Shimizu T
The Journal of biological chemistry   292(29) 12065-12076   Jul 2017   [Refereed]
Karigane D, Takubo K
International journal of hematology   106(1) 18-26   Jul 2017   [Refereed]
Takubo K, Morikawa T, Kobayashi H
[Rinsho ketsueki] The Japanese journal of clinical hematology   58(10) 1844-1850   2017   [Refereed]
Tokumoto Y, Tamaki S, Kabe Y, Takubo K, Suematsu M
Scientific reports   7(1) 1019   Apr 2017   [Refereed]
Morikawa T, Takubo K
Frontiers in cell and developmental biology   5 62   2017   [Refereed]
[Stress response mechanism in hematopoietic stem cells.]
Takubo K
Clinical calcium   27(6) 823-828   2017   [Refereed]
Fujita N, Suzuki S, Watanabe K, Ishii K, Watanabe R, Shimoda M, Takubo K, Tsuji T, Toyama Y, Miyamoto T, Horiuchi K, Nakamura M, Matsumoto M
Journal of orthopaedic research : official publication of the Orthopaedic Research Society   34(8) 1341-1350   Aug 2016   [Refereed]
Koide S, Oshima M, Takubo K, Yamazaki S, Nitta E, Saraya A, Aoyama K, Kato Y, Miyagi S, Nakajima-Takagi Y, Chiba T, Matsui H, Arai F, Suzuki Y, Kimura H, Nakauchi H, Suda T, Shinkai Y, Iwama A
Blood   128(5) 638-649   Aug 2016   [Refereed]
Karigane D, Kobayashi H, Morikawa T, Ootomo Y, Sakai M, Nagamatsu G, Kubota Y, Goda N, Matsumoto M, Nishimura EK, Soga T, Otsu K, Suematsu M, Okamoto S, Suda T, Takubo K
Cell stem cell   19(2) 192-204   Aug 2016   [Refereed]
Ikeda K, Ueda T, Yamasaki N, Nakata Y, Sera Y, Nagamachi A, Miyama T, Kobayashi H, Takubo K, Kanai A, Oda H, Wolff L, Honda Z, Ichinohe T, Matsubara A, Suda T, Inaba T, Honda H
Scientific reports   6 29454   Jul 2016   [Refereed]
Hirasawa M, Takubo K, Osada H, Miyake S, Toda E, Endo M, Umezawa K, Tsubota K, Oike Y, Ozawa Y
The Journal of biological chemistry   291(14) 7373-7385   Apr 2016   [Refereed]
Baba M, Toyama H, Sun L, Takubo K, Suh HC, Hasumi H, Nakamura-Ishizu A, Hasumi Y, Klarmann KD, Nakagata N, Schmidt LS, Linehan WM, Suda T, Keller JR
Stem cells (Dayton, Ohio)   34(4) 1068-1082   Apr 2016   [Refereed]
Kobayashi H, Suda T, Takubo K
Experimental hematology   44(2) 92-100   Feb 2016   [Refereed]
Ishii A, Kimura T, Sadahiro H, Kawano H, Takubo K, Suzuki M, Ikeda E
PloS one   11(1) e0147366   Jan 2016   [Refereed]
Nakamura-Ishizu A, Takubo K, Kobayashi H, Suzuki-Inoue K, Suda T
The Journal of experimental medicine   212(13) 2323   Dec 2015   [Refereed]
Suzuki S, Fujita N, Hosogane N, Watanabe K, Ishii K, Toyama Y, Takubo K, Horiuchi K, Miyamoto T, Nakamura M, Matsumoto M
Arthritis research & therapy   17 316   Nov 2015   [Refereed]
Nakamura-Ishizu A, Takubo K, Kobayashi H, Suzuki-Inoue K, Suda T
The Journal of experimental medicine   212(12) 2133-2146   Nov 2015   [Refereed]
Takubo K
[Rinsho ketsueki] The Japanese journal of clinical hematology   56(10) 1882-1887   Oct 2015   [Refereed]
Morikawa T, Takubo K
Pflugers Archiv : European journal of physiology      Oct 2015   [Refereed]
Cui D, Arima M, Takubo K, Kimura T, Horiuchi K, Minagawa T, Matsuda S, Ikeda E
Scientific reports   5 12796   Aug 2015   [Refereed]
Nagamatsu G, Saito S, Takubo K, Suda T
Stem cell reports   5(1) 111-124   Jul 2015   [Refereed]
Taimatsu K, Takubo K, Maruyama K, Suda T, Kudo A
Developmental dynamics : an official publication of the American Association of Anatomists   244(5) 651-668   May 2015   [Refereed]
Ueda T, Nagamachi A, Takubo K, Yamasaki N, Matsui H, Kanai A, Nakata Y, Ikeda K, Konuma T, Oda H, Wolff L, Honda Z, Wu X, Helin K, Iwama A, Suda T, Inaba T, Honda H
Blood   125(22) 3437-3446   May 2015   [Refereed]
Kobayashi H, Kobayashi CI, Nakamura-Ishizu A, Karigane D, Haeno H, Yamamoto KN, Sato T, Ohteki T, Hayakawa Y, Barber GN, Kurokawa M, Suda T, Takubo K
Cell reports   11(1) 71-84   Apr 2015   [Refereed]
[Homeostatic regulation of hematopoiesis by the hematopoietic stem cell niche].
Takubo K
Seikagaku. The Journal of Japanese Biochemical Society   86(6) 755-765   Dec 2014   [Refereed]
Nakamura-Ishizu A, Takubo K, Fujioka M, Suda T
Biochemical and biophysical research communications   454(2) 353-357   Nov 2014   [Refereed]
Kawasaki M, Porntaveetus T, Kawasaki K, Oommen S, Otsuka-Tanaka Y, Hishinuma M, Nomoto T, Maeda T, Takubo K, Suda T, Sharpe PT, Ohazama A
Developmental dynamics : an official publication of the American Association of Anatomists   243(6) 844-851   Jun 2014   [Refereed]
Kunimoto H, Fukuchi Y, Sakurai M, Takubo K, Okamoto S, Nakajima H
Blood   123(18) 2897-2899   May 2014   [Refereed]
Kobayashi CI, Takubo K, Kobayashi H, Nakamura-Ishizu A, Honda H, Kataoka K, Kumano K, Akiyama H, Sudo T, Kurokawa M, Suda T
Blood   123(16) 2540-2549   Apr 2014   [Refereed]
Kinoshita T, Nagamatsu G, Saito S, Takubo K, Horimoto K, Suda T
The Journal of biological chemistry   289(22) 15776-15787   Apr 2014   [Refereed]
Takubo K, Suda T
Blood   123(2) 151-152   Jan 2014   [Refereed]
Nagamachi A, Nakata Y, Ueda T, Yamasaki N, Ebihara Y, Tsuji K, Honda Z, Takubo K, Suda T, Oda H, Inaba T, Honda H
PloS one   9(1) e87425   Jan 2014   [Refereed]
Nagamachi A, Matsui H, Asou H, Ozaki Y, Aki D, Kanai A, Takubo K, Suda T, Nakamura T, Wolff L, Honda H, Inaba T
Cancer cell   24(3) 305-317   Sep 2013   [Refereed]
Nagamatsu G, Kosaka T, Saito S, Honda H, Takubo K, Kinoshita T, Akiyama H, Sudo T, Horimoto K, Oya M, Suda T
Stem cells (Dayton, Ohio)   31(3) 479-487   Mar 2013   [Refereed]
Ikushima YM, Arai F, Hosokawa K, Toyama H, Takubo K, Furuyashiki T, Narumiya S, Suda T
Blood   121(11) 1995-2007   Mar 2013   [Refereed]
Takubo K, Nagamatsu G, Kobayashi CI, Nakamura-Ishizu A, Kobayashi H, Ikeda E, Goda N, Rahimi Y, Johnson RS, Soga T, Hirao A, Suematsu M, Suda T
Cell stem cell   12(1) 49-61   Jan 2013   [Refereed]
Nagamatsu G, Saito S, Kosaka T, Takubo K, Kinoshita T, Oya M, Horimoto K, Suda T
The Journal of biological chemistry   287(43) 36273-36282   Oct 2012   [Refereed]
Nagamatsu G, Kosaka T, Saito S, Takubo K, Akiyama H, Sudo T, Horimoto K, Oya M, Suda T
Biology of reproduction   86(6) 182   Jun 2012   [Refereed]
Takubo K, Suda T
International journal of hematology   95(5) 478-483   May 2012   [Refereed]
Ikejiri A, Nagai S, Goda N, Kurebayashi Y, Osada-Oka M, Takubo K, Suda T, Koyasu S
International immunology   24(3) 137-146   Mar 2012   [Refereed]
Iriuchishima H, Takubo K, Miyakawa Y, Nakamura-Ishizu A, Miyauchi Y, Fujita N, Miyamoto K, Miyamoto T, Ikeda E, Kizaki M, Nojima Y, Suda T
PloS one   7(2) e30557   2012   [Refereed]
Takaesu G, Inagaki M, Takubo K, Mishina Y, Hess PR, Dean GA, Yoshimura A, Matsumoto K, Suda T, Ninomiya-Tsuji J
PloS one   7(11) e51073   2012   [Refereed]
Suda T, Takubo K, Semenza GL
Cell stem cell   9(4) 298-310   Oct 2011   [Refereed]
Kubota Y, Takubo K, Hirashima M, Nagoshi N, Kishi K, Okuno Y, Nakamura-Ishizu A, Sano K, Murakami M, Ema M, Omatsu Y, Takahashi S, Nagasawa T, Shibuya M, Okano H, Suda T
The Journal of experimental medicine   208(5) 949-960   May 2011   [Refereed]
Nitta E, Yamashita M, Hosokawa K, Xian M, Takubo K, Arai F, Nakada S, Suda T
Blood   117(16) 4169-4180   Apr 2011   [Refereed]
Kinoshita T, Nagamatsu G, Kosaka T, Takubo K, Hotta A, Ellis J, Suda T
Biochemical and biophysical research communications   407(2) 321-326   Apr 2011   [Refereed]
Nagamatsu G, Kosaka T, Kawasumi M, Kinoshita T, Takubo K, Akiyama H, Sudo T, Kobayashi T, Oya M, Suda T
The Journal of biological chemistry   286(12) 10641-10648   Mar 2011   [Refereed]
Iriuchishima H, Takubo K, Matsuoka S, Onoyama I, Nakayama KI, Nojima Y, Suda T
Blood   117(8) 2373-2377   Feb 2011   [Refereed]
Honda H, Takubo K, Oda H, Kosaki K, Tazaki T, Yamasaki N, Miyazaki K, Moore KA, Honda Z, Suda T, Lemischka IR
Proceedings of the National Academy of Sciences of the United States of America   108(6) 2468-2473   Feb 2011   [Refereed]
Shima H, Takubo K, Tago N, Iwasaki H, Arai F, Takahashi T, Suda T
Experimental hematology   38(12) 1231-1240   Dec 2010   [Refereed]
Takubo K, Goda N, Yamada W, Iriuchishima H, Ikeda E, Kubota Y, Shima H, Johnson RS, Hirao A, Suematsu M, Suda T
Cell stem cell   7(3) 391-402   Sep 2010   [Refereed]
Kurihara T, Kubota Y, Ozawa Y, Takubo K, Noda K, Simon MC, Johnson RS, Suematsu M, Tsubota K, Ishida S, Goda N, Suda T, Okano H
Development (Cambridge, England)   137(9) 1563-1571   May 2010   [Refereed]
Hosokawa K, Arai F, Yoshihara H, Iwasaki H, Hembree M, Yin T, Nakamura Y, Gomei Y, Takubo K, Shiama H, Matsuoka S, Li L, Suda T
Cell stem cell   6(3) 194-198   Mar 2010   [Refereed]
Takubo K
[Rinsho ketsueki] The Japanese journal of clinical hematology   51 95-103   Feb 2010   [Refereed]
Kubota Y, Takubo K, Shimizu T, Ohno H, Kishi K, Shibuya M, Saya H, Suda T
The Journal of experimental medicine   206(5) 1089-1102   May 2009   [Refereed]
Yamada W, Nagao K, Horikoshi K, Fujikura A, Ikeda E, Inagaki Y, Kakitani M, Tomizuka K, Miyazaki H, Suda T, Takubo K
Biochemical and biophysical research communications   381(3) 453-458   Apr 2009   [Refereed]
Shima H, Takubo K, Iwasaki H, Yoshihara H, Gomei Y, Hosokawa K, Arai F, Takahashi T, Suda T
Biochemical and biophysical research communications   378(3) 467-472   Jan 2009   [Refereed]
Ohmura M, Naka K, Hoshii T, Muraguchi T, Shugo H, Tamase A, Uema N, Ooshio T, Arai F, Takubo K, Nagamatsu G, Hamaguchi I, Takagi M, Ishihara M, Sakurada K, Miyaji H, Suda T, Hirao A
Stem cells (Dayton, Ohio)   26(12) 3237-3246   Dec 2008   [Refereed]
Matsuoka S, Oike Y, Onoyama I, Iwama A, Arai F, Takubo K, Mashimo Y, Oguro H, Nitta E, Ito K, Miyamoto K, Yoshiwara H, Hosokawa K, Nakamura Y, Gomei Y, Iwasaki H, Hayashi Y, Matsuzaki Y, Nakayama K, Ikeda Y, Hata A, Chiba S, Nakayama KI, Suda T
Genes & development   22(8) 986-991   Apr 2008   [Refereed]
Kubota Y, Takubo K, Suda T
Biochemical and biophysical research communications   366(2) 335-339   Feb 2008   [Refereed]
Takubo K, Ohmura M, Azuma M, Nagamatsu G, Yamada W, Arai F, Hirao A, Suda T
Cell stem cell   2(2) 170-182   Feb 2008   [Refereed]
Ikeda E, Takubo K, Kodama T, Okada Y
Developmental neuroscience   30(5) 331-339   2008   [Refereed]
Yoshihara H, Arai F, Hosokawa K, Hagiwara T, Takubo K, Nakamura Y, Gomei Y, Iwasaki H, Matsuoka S, Miyamoto K, Miyazaki H, Takahashi T, Suda T
Cell stem cell   1(6) 685-697   Dec 2007   [Refereed]
Morita K, Miyamoto T, Fujita N, Kubota Y, Ito K, Takubo K, Miyamoto K, Ninomiya K, Suzuki T, Iwasaki R, Yagi M, Takaishi H, Toyama Y, Suda T
The Journal of experimental medicine   204(7) 1613-1623   Jul 2007   [Refereed]
Miyamoto K, Araki KY, Naka K, Arai F, Takubo K, Yamazaki S, Matsuoka S, Miyamoto T, Ito K, Ohmura M, Chen C, Hosokawa K, Nakauchi H, Nakayama K, Nakayama KI, Harada M, Motoyama N, Suda T, Hirao A
Cell stem cell   1(1) 101-112   Jun 2007   [Refereed]
Koto T, Takubo K, Ishida S, Shinoda H, Inoue M, Tsubota K, Okada Y, Ikeda E
The American journal of pathology   170(4) 1389-1397   Apr 2007   [Refereed]
Regulation of reactive oxygen species by Atm is essential for proper response to DNA double-strand breaks in lymphocytes.
Ito K, Takubo K, Arai F, Satoh H, Matsuoka S, Ohmura M, Naka K, Azuma M, Miyamoto K, Hosokawa K, Ikeda Y, Mak TW, Suda T, Hirao A
Journal of immunology (Baltimore, Md. : 1950)   178(1) 103-110   Jan 2007   [Refereed]
Takubo K, Hirao A, Ohmura M, Azuma M, Arai F, Nagamatsu G, Suda T
Biochemical and biophysical research communications   351(4) 993-998   Dec 2006   [Refereed]
Ito K, Hirao A, Arai F, Takubo K, Matsuoka S, Miyamoto K, Ohmura M, Naka K, Hosokawa K, Ikeda Y, Suda T
Nature medicine   12(4) 446-451   Apr 2006   [Refereed]
[Hematopoietic stem cell niche in bone marrow].
Takubo K, Hirao A, Suda T
Seikagaku. The Journal of Japanese Biochemical Society   78 301-309   Apr 2006   [Refereed]
Azuma M, Hirao A, Takubo K, Hamaguchi I, Kitamura T, Suda T
Biochemical and biophysical research communications   338(2) 1164-1170   Dec 2005   [Refereed]
Ito K, Hirao A, Arai F, Matsuoka S, Takubo K, Hamaguchi I, Nomiyama K, Hosokawa K, Sakurada K, Nakagata N, Ikeda Y, Mak TW, Suda T
Nature   431(7011) 997-1002   Oct 2004   [Refereed]
Arai F, Hirao A, Ohmura M, Sato H, Matsuoka S, Takubo K, Ito K, Koh GY, Suda T
Cell   118(2) 149-161   Jul 2004   [Refereed]

Misc

 
TAKUBO Keiyo
The Japanese journal of clinical hematology   51(2) 95-103   Feb 2010
TAKUBO Keiyo, HIRAO Atsushi, SUDA Toshio
78(4) 301-309   Apr 2006

Conference Activities & Talks

 
Functional alteration of hematopoietic stem cell niche during aging
Keiyo Takubo
?IMSUT Mini-Symposium   Jul 2018   
Metabolic switch in hematopoietic stem cells during stress
Keiyo Takubo
WCP2018 KYOTO Satellite Symposia   Jul 2018   
Metabolic regulation of hematopoietic stem cell during stress
Keiyo Takubo
JSPS-NUS Joint 2nd symposium   Jan 2018   
Aging Program of Hematopoietic Stem Cells
Keiyo Takubo
Cell Press LabLinks   Nov 2017   
Metabolic regulation and hematopoietic stem cell aging
Keiyo Takubo
The 27th Hot Spring Harbor International Symposium   Nov 2017   
p38α protects hematopoietic stem/progenitor cells in acute and aging stresses
Keiyo Takubo
Scientific Working Group, 22nd Congress of European Hematology Association   Jun 2017   
Transcriptional and metabolic program for hematopoietic stem cell aging
Keiyo Takubo
Tohoku Forum for Creativity Thematic Program “Aging Science: from Molecules to Society”   May 2017   
Metabolic regulation of hematopoietic stem cell function
Keiyo Takubo
第94回日本生理学会大会   Mar 2017   

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(若手研究(B))
Project Year: 2009 - 2010    Investigator(s): Keiyo TAKUBO
Hematopoietic stem cells (HSCs) are sustained in a specific microenvironment known as the stem cell niche. Mammalian HSCs are kept quiescent in the endosteal niche, a hypoxic zone of the bone marrow (BM). We found that normal HSCs maintain intrace...