Keiyo Takubo Last updated: Dec 2, 2019 at 17:27
Academic & Professional Experience
Apr 2014
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Today
Project director, Research Institute, National Institute for Global Health and Medicine
Nov 2011
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Mar 2015
Senior assistant professor, School of Medicine, Keio University
Apr 2008
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Oct 2011
Assistant professor, School of Medicine, Keio University
Apr 2006
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Mar 2008
Research fellow, The Japan Society for the Promotion of Science
Published Papers
Tsuchiya N, Zhang R, Iwama T, Ueda N, Liu T, Tatsumi M, Sasaki Y, Shimoda R, Osako Y, Sawada Y, Kubo Y, Miyashita A, Fukushima S, Cheng Z, Nakaki R, Takubo K, Okada S, Kaneko S, Ihn H, Kaisho T, Nishimura Y, Senju S, Endo I, Nakatsura T, Uemura Y
Cell reports 29(1) 162-175.e9 Oct 2019 [Refereed]
Nagai M, Noguchi R, Takahashi D, Morikawa T, Koshida K, Komiyama S, Ishihara N, Yamada T, Kawamura YI, Muroi K, Hattori K, Kobayashi N, Fujimura Y, Hirota M, Matsumoto R, Aoki R, Tamura-Nakano M, Sugiyama M, Katakai T, Sato S, Takubo K, Dohi T, Hase K
Cell 178(5) 1072-1087.e14 Aug 2019 [Refereed]
Kobayashi H, Morikawa T, Okinaga A, Hamano F, Hashidate-Yoshida T, Watanuki S, Hishikawa D, Shindou H, Arai F, Kabe Y, Suematsu M, Shimizu T, Takubo K
Cell reports 28(1) 145-158.e9 Jul 2019 [Refereed]
Watanuki S, Kobayashi H, Sorimachi Y, Yamamoto M, Okamoto S, Takubo K
Biochemical and biophysical research communications 514(1) 287-294 Jun 2019 [Refereed]
Mima Y, Suzuki S, Fujii T, Morikawa T, Tamaki S, Takubo K, Shimoda M, Miyamoto T, Watanabe K, Matsumoto M, Nakamura M, Fujita N
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 37(4) 972-980 Apr 2019 [Refereed]
Goto S, Morikawa T, Kubo A, Takubo K, Fukuda K, Kajimura M, Suematsu M
Journal of clinical biochemistry and nutrition 63(1) 70-79 Jul 2018 [Refereed]
Baba M, Endoh M, Ma W, Toyama H, Hirayama A, Nishikawa K, Takubo K, Hano H, Hasumi H, Umemoto T, Hashimoto M, Irie N, Esumi C, Kataoka M, Nakagata N, Soga T, Yao M, Kamba T, Minami T, Ishii M, Suda T
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research Jun 2018 [Refereed]
Shiota M, Naya M, Yamamoto T, Hishiki T, Tani T, Takahashi H, Kubo A, Koike D, Itoh M, Ohmura M, Kabe Y, Sugiura Y, Hiraoka N, Morikawa T, Takubo K, Suina K, Nagashima H, Sampetrean O, Nagano O, Saya H, Yamazoe S, Watanabe H, Suematsu M
Nature communications 9(1) 1561 Apr 2018 [Refereed]
Si S, Nakajima-Takagi Y, Iga T, Tsuji M, Hou L, Oshima M, Koide S, Saraya A, Yamazaki S, Takubo K, Kubota Y, Minamino T, Iwama A
Experimental hematology 63 41-51.e1 Apr 2018 [Refereed]
Iizuka-Hishikawa Y, Hishikawa D, Sasaki J, Takubo K, Goto M, Nagata K, Nakanishi H, Shindou H, Okamura T, Ito C, Toshimori K, Sasaki T, Shimizu T
The Journal of biological chemistry 292(29) 12065-12076 Jul 2017 [Refereed]
Karigane D, Takubo K
International journal of hematology 106(1) 18-26 Jul 2017 [Refereed]
Takubo K, Morikawa T, Kobayashi H
[Rinsho ketsueki] The Japanese journal of clinical hematology 58(10) 1844-1850 2017 [Refereed]
Tokumoto Y, Tamaki S, Kabe Y, Takubo K, Suematsu M
Scientific reports 7(1) 1019 Apr 2017 [Refereed]
Morikawa T, Takubo K
Frontiers in cell and developmental biology 5 62 2017 [Refereed]
[Stress response mechanism in hematopoietic stem cells.]
Takubo K
Clinical calcium 27(6) 823-828 2017 [Refereed]
Fujita N, Suzuki S, Watanabe K, Ishii K, Watanabe R, Shimoda M, Takubo K, Tsuji T, Toyama Y, Miyamoto T, Horiuchi K, Nakamura M, Matsumoto M
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 34(8) 1341-1350 Aug 2016 [Refereed]
Koide S, Oshima M, Takubo K, Yamazaki S, Nitta E, Saraya A, Aoyama K, Kato Y, Miyagi S, Nakajima-Takagi Y, Chiba T, Matsui H, Arai F, Suzuki Y, Kimura H, Nakauchi H, Suda T, Shinkai Y, Iwama A
Blood 128(5) 638-649 Aug 2016 [Refereed]
Karigane D, Kobayashi H, Morikawa T, Ootomo Y, Sakai M, Nagamatsu G, Kubota Y, Goda N, Matsumoto M, Nishimura EK, Soga T, Otsu K, Suematsu M, Okamoto S, Suda T, Takubo K
Cell stem cell 19(2) 192-204 Aug 2016 [Refereed]
Ikeda K, Ueda T, Yamasaki N, Nakata Y, Sera Y, Nagamachi A, Miyama T, Kobayashi H, Takubo K, Kanai A, Oda H, Wolff L, Honda Z, Ichinohe T, Matsubara A, Suda T, Inaba T, Honda H
Scientific reports 6 29454 Jul 2016 [Refereed]
Hirasawa M, Takubo K, Osada H, Miyake S, Toda E, Endo M, Umezawa K, Tsubota K, Oike Y, Ozawa Y
The Journal of biological chemistry 291(14) 7373-7385 Apr 2016 [Refereed]
Baba M, Toyama H, Sun L, Takubo K, Suh HC, Hasumi H, Nakamura-Ishizu A, Hasumi Y, Klarmann KD, Nakagata N, Schmidt LS, Linehan WM, Suda T, Keller JR
Stem cells (Dayton, Ohio) 34(4) 1068-1082 Apr 2016 [Refereed]
Kobayashi H, Suda T, Takubo K
Experimental hematology 44(2) 92-100 Feb 2016 [Refereed]
Ishii A, Kimura T, Sadahiro H, Kawano H, Takubo K, Suzuki M, Ikeda E
PloS one 11(1) e0147366 Jan 2016 [Refereed]
Nakamura-Ishizu A, Takubo K, Kobayashi H, Suzuki-Inoue K, Suda T
The Journal of experimental medicine 212(13) 2323 Dec 2015 [Refereed]
Suzuki S, Fujita N, Hosogane N, Watanabe K, Ishii K, Toyama Y, Takubo K, Horiuchi K, Miyamoto T, Nakamura M, Matsumoto M
Arthritis research & therapy 17 316 Nov 2015 [Refereed]
Nakamura-Ishizu A, Takubo K, Kobayashi H, Suzuki-Inoue K, Suda T
The Journal of experimental medicine 212(12) 2133-2146 Nov 2015 [Refereed]
Takubo K
[Rinsho ketsueki] The Japanese journal of clinical hematology 56(10) 1882-1887 Oct 2015 [Refereed]
Morikawa T, Takubo K
Pflugers Archiv : European journal of physiology Oct 2015 [Refereed]
Cui D, Arima M, Takubo K, Kimura T, Horiuchi K, Minagawa T, Matsuda S, Ikeda E
Scientific reports 5 12796 Aug 2015 [Refereed]
Nagamatsu G, Saito S, Takubo K, Suda T
Stem cell reports 5(1) 111-124 Jul 2015 [Refereed]
Taimatsu K, Takubo K, Maruyama K, Suda T, Kudo A
Developmental dynamics : an official publication of the American Association of Anatomists 244(5) 651-668 May 2015 [Refereed]
Ueda T, Nagamachi A, Takubo K, Yamasaki N, Matsui H, Kanai A, Nakata Y, Ikeda K, Konuma T, Oda H, Wolff L, Honda Z, Wu X, Helin K, Iwama A, Suda T, Inaba T, Honda H
Blood 125(22) 3437-3446 May 2015 [Refereed]
Kobayashi H, Kobayashi CI, Nakamura-Ishizu A, Karigane D, Haeno H, Yamamoto KN, Sato T, Ohteki T, Hayakawa Y, Barber GN, Kurokawa M, Suda T, Takubo K
Cell reports 11(1) 71-84 Apr 2015 [Refereed]
[Homeostatic regulation of hematopoiesis by the hematopoietic stem cell niche].
Takubo K
Seikagaku. The Journal of Japanese Biochemical Society 86(6) 755-765 Dec 2014 [Refereed]
Nakamura-Ishizu A, Takubo K, Fujioka M, Suda T
Biochemical and biophysical research communications 454(2) 353-357 Nov 2014 [Refereed]
Kawasaki M, Porntaveetus T, Kawasaki K, Oommen S, Otsuka-Tanaka Y, Hishinuma M, Nomoto T, Maeda T, Takubo K, Suda T, Sharpe PT, Ohazama A
Developmental dynamics : an official publication of the American Association of Anatomists 243(6) 844-851 Jun 2014 [Refereed]
Kunimoto H, Fukuchi Y, Sakurai M, Takubo K, Okamoto S, Nakajima H
Blood 123(18) 2897-2899 May 2014 [Refereed]
Kobayashi CI, Takubo K, Kobayashi H, Nakamura-Ishizu A, Honda H, Kataoka K, Kumano K, Akiyama H, Sudo T, Kurokawa M, Suda T
Blood 123(16) 2540-2549 Apr 2014 [Refereed]
Kinoshita T, Nagamatsu G, Saito S, Takubo K, Horimoto K, Suda T
The Journal of biological chemistry 289(22) 15776-15787 Apr 2014 [Refereed]
Takubo K, Suda T
Blood 123(2) 151-152 Jan 2014 [Refereed]
Nagamachi A, Nakata Y, Ueda T, Yamasaki N, Ebihara Y, Tsuji K, Honda Z, Takubo K, Suda T, Oda H, Inaba T, Honda H
PloS one 9(1) e87425 Jan 2014 [Refereed]
Nagamachi A, Matsui H, Asou H, Ozaki Y, Aki D, Kanai A, Takubo K, Suda T, Nakamura T, Wolff L, Honda H, Inaba T
Cancer cell 24(3) 305-317 Sep 2013 [Refereed]
Nagamatsu G, Kosaka T, Saito S, Honda H, Takubo K, Kinoshita T, Akiyama H, Sudo T, Horimoto K, Oya M, Suda T
Stem cells (Dayton, Ohio) 31(3) 479-487 Mar 2013 [Refereed]
Ikushima YM, Arai F, Hosokawa K, Toyama H, Takubo K, Furuyashiki T, Narumiya S, Suda T
Blood 121(11) 1995-2007 Mar 2013 [Refereed]
Takubo K, Nagamatsu G, Kobayashi CI, Nakamura-Ishizu A, Kobayashi H, Ikeda E, Goda N, Rahimi Y, Johnson RS, Soga T, Hirao A, Suematsu M, Suda T
Cell stem cell 12(1) 49-61 Jan 2013 [Refereed]
Nagamatsu G, Saito S, Kosaka T, Takubo K, Kinoshita T, Oya M, Horimoto K, Suda T
The Journal of biological chemistry 287(43) 36273-36282 Oct 2012 [Refereed]
Nagamatsu G, Kosaka T, Saito S, Takubo K, Akiyama H, Sudo T, Horimoto K, Oya M, Suda T
Biology of reproduction 86(6) 182 Jun 2012 [Refereed]
Takubo K, Suda T
International journal of hematology 95(5) 478-483 May 2012 [Refereed]
Ikejiri A, Nagai S, Goda N, Kurebayashi Y, Osada-Oka M, Takubo K, Suda T, Koyasu S
International immunology 24(3) 137-146 Mar 2012 [Refereed]
Iriuchishima H, Takubo K, Miyakawa Y, Nakamura-Ishizu A, Miyauchi Y, Fujita N, Miyamoto K, Miyamoto T, Ikeda E, Kizaki M, Nojima Y, Suda T
PloS one 7(2) e30557 2012 [Refereed]
Takaesu G, Inagaki M, Takubo K, Mishina Y, Hess PR, Dean GA, Yoshimura A, Matsumoto K, Suda T, Ninomiya-Tsuji J
PloS one 7(11) e51073 2012 [Refereed]
Suda T, Takubo K, Semenza GL
Cell stem cell 9(4) 298-310 Oct 2011 [Refereed]
Kubota Y, Takubo K, Hirashima M, Nagoshi N, Kishi K, Okuno Y, Nakamura-Ishizu A, Sano K, Murakami M, Ema M, Omatsu Y, Takahashi S, Nagasawa T, Shibuya M, Okano H, Suda T
The Journal of experimental medicine 208(5) 949-960 May 2011 [Refereed]
Nitta E, Yamashita M, Hosokawa K, Xian M, Takubo K, Arai F, Nakada S, Suda T
Blood 117(16) 4169-4180 Apr 2011 [Refereed]
Kinoshita T, Nagamatsu G, Kosaka T, Takubo K, Hotta A, Ellis J, Suda T
Biochemical and biophysical research communications 407(2) 321-326 Apr 2011 [Refereed]
Nagamatsu G, Kosaka T, Kawasumi M, Kinoshita T, Takubo K, Akiyama H, Sudo T, Kobayashi T, Oya M, Suda T
The Journal of biological chemistry 286(12) 10641-10648 Mar 2011 [Refereed]
Iriuchishima H, Takubo K, Matsuoka S, Onoyama I, Nakayama KI, Nojima Y, Suda T
Blood 117(8) 2373-2377 Feb 2011 [Refereed]
Honda H, Takubo K, Oda H, Kosaki K, Tazaki T, Yamasaki N, Miyazaki K, Moore KA, Honda Z, Suda T, Lemischka IR
Proceedings of the National Academy of Sciences of the United States of America 108(6) 2468-2473 Feb 2011 [Refereed]
Shima H, Takubo K, Tago N, Iwasaki H, Arai F, Takahashi T, Suda T
Experimental hematology 38(12) 1231-1240 Dec 2010 [Refereed]
Takubo K, Goda N, Yamada W, Iriuchishima H, Ikeda E, Kubota Y, Shima H, Johnson RS, Hirao A, Suematsu M, Suda T
Cell stem cell 7(3) 391-402 Sep 2010 [Refereed]
Kurihara T, Kubota Y, Ozawa Y, Takubo K, Noda K, Simon MC, Johnson RS, Suematsu M, Tsubota K, Ishida S, Goda N, Suda T, Okano H
Development (Cambridge, England) 137(9) 1563-1571 May 2010 [Refereed]
Hosokawa K, Arai F, Yoshihara H, Iwasaki H, Hembree M, Yin T, Nakamura Y, Gomei Y, Takubo K, Shiama H, Matsuoka S, Li L, Suda T
Cell stem cell 6(3) 194-198 Mar 2010 [Refereed]
Takubo K
[Rinsho ketsueki] The Japanese journal of clinical hematology 51 95-103 Feb 2010 [Refereed]
Kubota Y, Takubo K, Shimizu T, Ohno H, Kishi K, Shibuya M, Saya H, Suda T
The Journal of experimental medicine 206(5) 1089-1102 May 2009 [Refereed]
Yamada W, Nagao K, Horikoshi K, Fujikura A, Ikeda E, Inagaki Y, Kakitani M, Tomizuka K, Miyazaki H, Suda T, Takubo K
Biochemical and biophysical research communications 381(3) 453-458 Apr 2009 [Refereed]
Shima H, Takubo K, Iwasaki H, Yoshihara H, Gomei Y, Hosokawa K, Arai F, Takahashi T, Suda T
Biochemical and biophysical research communications 378(3) 467-472 Jan 2009 [Refereed]
Ohmura M, Naka K, Hoshii T, Muraguchi T, Shugo H, Tamase A, Uema N, Ooshio T, Arai F, Takubo K, Nagamatsu G, Hamaguchi I, Takagi M, Ishihara M, Sakurada K, Miyaji H, Suda T, Hirao A
Stem cells (Dayton, Ohio) 26(12) 3237-3246 Dec 2008 [Refereed]
Matsuoka S, Oike Y, Onoyama I, Iwama A, Arai F, Takubo K, Mashimo Y, Oguro H, Nitta E, Ito K, Miyamoto K, Yoshiwara H, Hosokawa K, Nakamura Y, Gomei Y, Iwasaki H, Hayashi Y, Matsuzaki Y, Nakayama K, Ikeda Y, Hata A, Chiba S, Nakayama KI, Suda T
Genes & development 22(8) 986-991 Apr 2008 [Refereed]
Kubota Y, Takubo K, Suda T
Biochemical and biophysical research communications 366(2) 335-339 Feb 2008 [Refereed]
Takubo K, Ohmura M, Azuma M, Nagamatsu G, Yamada W, Arai F, Hirao A, Suda T
Cell stem cell 2(2) 170-182 Feb 2008 [Refereed]
Ikeda E, Takubo K, Kodama T, Okada Y
Developmental neuroscience 30(5) 331-339 2008 [Refereed]
Yoshihara H, Arai F, Hosokawa K, Hagiwara T, Takubo K, Nakamura Y, Gomei Y, Iwasaki H, Matsuoka S, Miyamoto K, Miyazaki H, Takahashi T, Suda T
Cell stem cell 1(6) 685-697 Dec 2007 [Refereed]
Morita K, Miyamoto T, Fujita N, Kubota Y, Ito K, Takubo K, Miyamoto K, Ninomiya K, Suzuki T, Iwasaki R, Yagi M, Takaishi H, Toyama Y, Suda T
The Journal of experimental medicine 204(7) 1613-1623 Jul 2007 [Refereed]
Miyamoto K, Araki KY, Naka K, Arai F, Takubo K, Yamazaki S, Matsuoka S, Miyamoto T, Ito K, Ohmura M, Chen C, Hosokawa K, Nakauchi H, Nakayama K, Nakayama KI, Harada M, Motoyama N, Suda T, Hirao A
Cell stem cell 1(1) 101-112 Jun 2007 [Refereed]
Koto T, Takubo K, Ishida S, Shinoda H, Inoue M, Tsubota K, Okada Y, Ikeda E
The American journal of pathology 170(4) 1389-1397 Apr 2007 [Refereed]
Regulation of reactive oxygen species by Atm is essential for proper response to DNA double-strand breaks in lymphocytes.
Ito K, Takubo K, Arai F, Satoh H, Matsuoka S, Ohmura M, Naka K, Azuma M, Miyamoto K, Hosokawa K, Ikeda Y, Mak TW, Suda T, Hirao A
Journal of immunology (Baltimore, Md. : 1950) 178(1) 103-110 Jan 2007 [Refereed]
Takubo K, Hirao A, Ohmura M, Azuma M, Arai F, Nagamatsu G, Suda T
Biochemical and biophysical research communications 351(4) 993-998 Dec 2006 [Refereed]
Ito K, Hirao A, Arai F, Takubo K, Matsuoka S, Miyamoto K, Ohmura M, Naka K, Hosokawa K, Ikeda Y, Suda T
Nature medicine 12(4) 446-451 Apr 2006 [Refereed]
[Hematopoietic stem cell niche in bone marrow].
Takubo K, Hirao A, Suda T
Seikagaku. The Journal of Japanese Biochemical Society 78 301-309 Apr 2006 [Refereed]
Azuma M, Hirao A, Takubo K, Hamaguchi I, Kitamura T, Suda T
Biochemical and biophysical research communications 338(2) 1164-1170 Dec 2005 [Refereed]
Ito K, Hirao A, Arai F, Matsuoka S, Takubo K, Hamaguchi I, Nomiyama K, Hosokawa K, Sakurada K, Nakagata N, Ikeda Y, Mak TW, Suda T
Nature 431(7011) 997-1002 Oct 2004 [Refereed]
Arai F, Hirao A, Ohmura M, Sato H, Matsuoka S, Takubo K, Ito K, Koh GY, Suda T
Cell 118(2) 149-161 Jul 2004 [Refereed]
Misc
TAKUBO Keiyo
The Japanese journal of clinical hematology 51(2) 95-103 Feb 2010
TAKUBO Keiyo, HIRAO Atsushi, SUDA Toshio
78(4) 301-309 Apr 2006
Conference Activities & Talks
Functional alteration of hematopoietic stem cell niche during aging
Keiyo Takubo
?IMSUT Mini-Symposium Jul 2018
Metabolic switch in hematopoietic stem cells during stress
Keiyo Takubo
WCP2018 KYOTO Satellite Symposia Jul 2018
Metabolic regulation of hematopoietic stem cell during stress
Keiyo Takubo
JSPS-NUS Joint 2nd symposium Jan 2018
Aging Program of Hematopoietic Stem Cells
Keiyo Takubo
Cell Press LabLinks Nov 2017
Metabolic regulation and hematopoietic stem cell aging
Keiyo Takubo
The 27th Hot Spring Harbor International Symposium Nov 2017
p38α protects hematopoietic stem/progenitor cells in acute and aging stresses
Keiyo Takubo
Scientific Working Group, 22nd Congress of European Hematology Association Jun 2017
Transcriptional and metabolic program for hematopoietic stem cell aging
Keiyo Takubo
Tohoku Forum for Creativity Thematic Program “Aging Science: from Molecules to Society” May 2017
Metabolic regulation of hematopoietic stem cell function
Keiyo Takubo
第94回日本生理学会大会 Mar 2017
Research Grants & Projects
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(若手研究(B))
Project Year: 2009 - 2010 Investigator(s): Keiyo TAKUBO
Hematopoietic stem cells (HSCs) are sustained in a specific microenvironment known as the stem cell niche. Mammalian HSCs are kept quiescent in the endosteal niche, a hypoxic zone of the bone marrow (BM). We found that normal HSCs maintain intrace...
