Keiyo Takubo
(田久保 圭誉)
Modified on: 02/13
Profile Information
- Affiliation
- Professor, Graduate School of Medicine, Tohoku University
- National Center for Global Health and Medicine
- Degree
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博士(医学)(慶應義塾大学)
- J-GLOBAL ID
- 201401087385042716
- researchmap Member ID
- B000237762
- External link
私たちのからだの細胞の三分の二を占める血液細胞を作り出す、造血幹細胞の研究をしています。造血幹細胞は定常状態ではほとんど分裂せず骨の中・骨髄で「休眠」しています。この骨髄に静かにたたずむ造血幹細胞が維持される機構や、必要に応じて血液細胞の産生を行うメカニズムには不明な点が多く残されています。また、個体の発生や老化において生じる造血幹細胞の異常はさまざまな疾患の発症につながります。私たちの研究室では各種の動物モデルや生体内可視化、オミックス解析などの先端手法を用いて、発生・炎症・老化などの様々な状況における造血幹細胞の研究を日夜行っています。これらの研究を通じて私たちのからだが維持されるメカニズムと、その破綻による疾患を深く理解したいと考えています。
Research Interests
32Research History
5-
Dec, 2023 - Present
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Nov, 2011 - Mar, 2015
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Apr, 2008 - Oct, 2011
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Apr, 2006 - Mar, 2008
Awards
8-
Nov, 2017
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Mar, 2017
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Apr, 2016
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Nov, 2015
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Apr, 2014
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Jan, 2014
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Sep, 2013
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Oct, 2008
Papers
114-
Metabolism: clinical and experimental, 155796-155796, Jan 21, 2024
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Nature Cell Biology, Oct 5, 2023 Peer-reviewedCorresponding author
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Proceedings of the National Academy of Sciences of the United States of America, 120(32) e2206860120, Aug 8, 2023 Peer-reviewedLead authorCorresponding author
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Experimental hematology, Jun 18, 2023 Peer-reviewedLast authorCorresponding author
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STAR protocols, 4(2) 102347-102347, Jun 9, 2023 Peer-reviewedLast authorCorresponding author
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Stem cell reports, 18(5) 1211-1226, Apr 4, 2023 Peer-reviewedLast authorCorresponding author
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European journal of human genetics : EJHG, Mar 27, 2023
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Mar 16, 2023 Last authorCorresponding author
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Journal of clinical medicine, 12(3), Jan 19, 2023
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Communications biology, 5(1) 1420-1420, Dec 28, 2022
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Cell Reports Methods, 2(12) 100354-100354, Dec, 2022 Peer-reviewedLast authorCorresponding author
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Cells, 11(20), Oct 11, 2022 Peer-reviewedLast authorCorresponding author
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Experimental Hematology, 112-113 44-59, Jul, 2022 Peer-reviewedLast authorCorresponding author
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Biochemical and biophysical research communications, 596 29-35, Mar 12, 2022 Peer-reviewedLast authorCorresponding author
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日本血液学会学術集会, 83回 OS1-5, Sep, 2021
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日本血液学会学術集会, 83回 OS2-2, Sep, 2021
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Proceedings of the National Academy of Sciences of the United States of America, 118(33), Aug 17, 2021 Peer-reviewed
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Nature, 595(7866) 266-271, Jul, 2021 Peer-reviewed
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Journal of visualized experiments : JoVE, (171), May 17, 2021 Peer-reviewedLast authorCorresponding author
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The Journal of biological chemistry, 296 100563-100563, Mar 18, 2021 Peer-reviewed
Misc.
142-
Novel genome editing system optimized to preserve the hematopoietic stem cell function and phenotype日本血液学会学術集会抄録(Web), 83rd, 2021
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再生医療, 19(3) 234-238, Aug, 2020
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実験医学, 38(9) 1424-1428, Jun, 2020
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実験医学, 38(9) 1436-1440, Jun, 2020
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臨床免疫・アレルギー科, 73(5) 467-471, May, 2020
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日本血液学会学術集会抄録(Web), 82nd, 2020
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日本生化学会大会プログラム・講演要旨集, 92回 [1S12m-04], Sep, 2019
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血液内科, 79(3) 321-326, Sep, 2019
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日本生化学会大会プログラム・講演要旨集, 92回 [1S12m-04], Sep, 2019
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医学のあゆみ, 270(5) 425-428, Aug, 2019
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日本抗加齢医学会総会プログラム・抄録集, 19回 116-116, Jun, 2019
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先進医薬研究振興財団研究成果報告集, 2018年度 144-145, Mar, 2019
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先進医薬研究振興財団研究成果報告集, 2018年度 144-145, Mar, 2019
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病理と臨床, 36(12) 1174-1181, Dec, 2018
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生体の科学, 69(5) 440-441, Oct, 2018
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血液フロンティア, 28(11) 1563-1568, Oct, 2018
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臨床血液, 59(9) 1576-1576, Sep, 2018
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臨床血液, 59(9) 1483-1483, Sep, 2018
Books and Other Publications
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羊土社, 2015 (ISBN: 9784758101417)
Presentations
19-
日本比較免疫学会第30回学術集会, Aug, 2018
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?IMSUT Mini-Symposium, Jul, 2018
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WCP2018 KYOTO Satellite Symposia, Jul, 2018
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第18回日本抗加齢医学会総会, May, 2018
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第6回がんと代謝研究会, May, 2018
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JSPS-NUS Joint 2nd symposium, Jan, 2018
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CONBIO2017, Dec, 2017
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JST-CRDSライフサイエンス・臨床医学分野“恒常性”区分俯瞰ワークショップ 「4次元生体リモデリング」, Nov, 2017
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Cell Press LabLinks, Nov, 2017
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The 27th Hot Spring Harbor International Symposium, Nov, 2017
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第14回レドックス・ライフイノベーションシンポジウム, Oct, 2017
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第79回日本血液学会学術集会教育講演, Oct, 2017
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東京医科歯科大学難治疾患研究所セミナー, Sep, 2017
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Scientific Working Group, 22nd Congress of European Hematology Association, Jun, 2017
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Tohoku Forum for Creativity Thematic Program “Aging Science: from Molecules to Society”, May, 2017
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慶應義塾大学医学部血液内科セミナー, May, 2017
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東京大学分子細胞生物学研究所セミナー, Apr, 2017
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第94回日本生理学会大会, Mar, 2017
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第4回発生と代謝を考える会, Feb, 2017
Research Projects
23-
Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2024
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Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2020 - Mar, 2023
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Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jul, 2020 - Mar, 2022
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科学研究費助成事業 基盤研究(B), 基盤研究(B), 日本学術振興会, Apr, 2018 - Mar, 2021
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科学研究費助成事業 挑戦的研究(萌芽), 挑戦的研究(萌芽), 日本学術振興会, Jun, 2018 - Mar, 2020
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Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019
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Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Nov, 2015 - Mar, 2019
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Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Jul, 2014 - Mar, 2019
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Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Jul, 2014 - Mar, 2019
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Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Jul, 2014 - Mar, 2019
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Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (S), Japan Society for the Promotion of Science, May, 2014 - Mar, 2019
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Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2018
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Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018
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科学研究費助成事業 新学術領域研究(研究領域提案型), 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2013 - Mar, 2015
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Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (A), Japan Society for the Promotion of Science, Apr, 2011 - Mar, 2015
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Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Apr, 2010 - Mar, 2015
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Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2011 - Mar, 2014
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科学研究費助成事業 新学術領域研究(研究領域提案型), 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2011 - Mar, 2013
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科学研究費助成事業, 基盤研究(S), 日本学術振興会, 2010 - 2010
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科学研究費助成事業, 特定領域研究, 日本学術振興会, 2009 - 2010