論文

査読有り 最終著者 国際誌
2018年6月

Expression of aggrecan components in perineuronal nets in the mouse cerebral cortex.

IBRO reports
  • Hiroshi Ueno
  • ,
  • Kazuki Fujii
  • ,
  • Shunsuke Suemitsu
  • ,
  • Shinji Murakami
  • ,
  • Naoya Kitamura
  • ,
  • Kenta Wani
  • ,
  • Shozo Aoki
  • ,
  • Motoi Okamoto
  • ,
  • Takeshi Ishihara
  • ,
  • Keizo Takao

4
4
開始ページ
22
終了ページ
37
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.ibror.2018.01.002

Specific regions of the cerebral cortex are highly plastic in an organism's lifetime. It is thought that perineuronal nets (PNNs) regulate plasticity, but labeling for Wisteria floribunda agglutinin (WFA), which is widely used to detect PNNs, is observed throughout the cortex. The aggrecan molecule-a PNN component-may regulate plasticity, and may also be involved in determining region-specific vulnerability to stress. To clarify cortical region-specific plasticity and vulnerability, we qualitatively analyzed aggrecan-positive and glycosylated aggrecan-positive PNNs in the mature mouse cerebral cortex. Our findings revealed the selective expression of both aggrecan-positive and glycosylated aggrecan-positive PNNs in the cortex. WFA-positive PNNs expressed aggrecan in a region-specific manner in the cortex. Furthermore, we observed variable distributions of PNNs containing WFA- and aggrecan-positive molecules. Together, our findings suggest that PNN components and their function differ depending on the cortical region, and that aggrecan molecules may be involved in determining region-specific plasticity and vulnerability in the cortex.

リンク情報
DOI
https://doi.org/10.1016/j.ibror.2018.01.002
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30135949
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6084874
ID情報
  • DOI : 10.1016/j.ibror.2018.01.002
  • PubMed ID : 30135949
  • PubMed Central 記事ID : PMC6084874

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