2013年2月
Mechanobiology in cardiac physiology and diseases
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- ,
- ,
- ,
- 巻
- 17
- 号
- 2
- 開始ページ
- 225
- 終了ページ
- 232
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1111/jcmm.12027
- 出版者・発行元
- WILEY-BLACKWELL
Mechanosensitivity is essential for heart function just as for all other cells and organs in the body, and it is involved in both normal physiology and diseases processes of the cardiovascular system. In this review, we have outlined the relationship between mechanosensitivity and heart physiology, including the FrankStarling law of the heart and mechanoelectric feedback. We then focused on molecules involved in mechanotransduction, particularly mechanosensitive ion channels. We have also discussed the involvement of mechanosensitivity in heart diseases, such as arrhythmias, hypertrophy and ischaemic heart disease. Finally, mechanobiology in cardiogenesis is described with regard to regenerative medicine.
- リンク情報
- ID情報
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- DOI : 10.1111/jcmm.12027
- ISSN : 1582-1838
- Web of Science ID : WOS:000315488200002