Kenichi Ishii

Profile Information

Affiliation: Assistant Professor, Department of Biological Sciences, Graduate School of Science, The University of Tokyo

Degree: Ph.D.(Mar, 2012, The University of Tokyo)

J-GLOBAL ID: 201201062878873059
researchmap Member ID: B000225473

Research Interests

Research Areas

Research History

Sep, 2020 - Present

Assistant Professor, Graduate School of Science, The University of Tokyo
Apr, 2015 - Aug, 2020

Postdoctoral fellow, Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies (La Jolla, CA, USA)
Apr, 2016 - Mar, 2018

Postdoctoral Fellowships for Research Abroad, Japan Society for the Promotion of Science, Salk Institute of Biological Studies (La Jolla, CA, USA)
Apr, 2012 - Mar, 2015

Research Fellowships for Young Scientists (PD), Japan Society for the Promotion of Science, Graduate School of Science, The University of Tokyo

Education

Apr, 2009 - Mar, 2012

Ph.D. program (Prof. Kazuhisa Sekimizu), Graduate School of Pharmaceutical Sciences, The University of Tokyo
Apr, 2007 - Mar, 2009

Ms. program (Prof. Kazuhisa Sekimizu), Graduate School of Pharmaceutical Sciences, The University of Tokyo
Apr, 2003 - Mar, 2007

Department of Pharmacy, Faculty of Pharmaceutical Sciences, The University of Tokyo

Awards

Sep, 2022

Daigoro Moriwaki Award, Japan Drosophila Research Conference (JDRC)
Nov, 2020

The University of Tokyo Excellent Young Researcher, The University of Tokyo
Mar, 2015

Subsidy for Research Abroad, The Naito Foundation
Mar, 2012

The University of Tokyo President’s Award for Students, The University of Tokyo
Mar, 2012

Ikushi Prize, Japan Society for the Promotion of Science

Papers

29

Descending GABAergic pathway links brain sugar-sensing to peripheral nociceptive gating in Drosophila

Mami Nakamizo-Dojo*, Kenichi Ishii*, Jiro Yoshino*, Masato Tsuji, Kazuo Emoto [*Equal contribution]

Nature Communications, 14 6515, Oct 16, 2023 Peer-reviewedLead author
Presynaptic Ube3a E3 ligase promotes synapse elimination through down-regulation of BMP signaling

Kotaro Furusawa, Kenichi Ishii, Masato Tsuji, Nagomi Tokumitsu, Eri Hasegawa, Kazuo Emoto

Science, 381(6663) 1197-1205, Sep, 2023 Peer-reviewed
50

A neurogenetic mechanism of experience-dependent suppression of aggression

Kenichi Ishii, Matteo Cortese, Xubo Leng, Maxim N Shokhirev, Kenta Asahina

Science Advances, 8(36) eabg3203, Sep 9, 2022 Peer-reviewedLead author
70

Serum apolipoprotein A-I potentiates the therapeutic efficacy of lysocin E against Staphylococcus aureus

Hiroshi Hamamoto*, Suresh Panthee*, Atmika Paudel, Kenichi Ishii, Jyunichiro Yasukawa, Su Jie, Atsushi Miyashita, Hiroaki Itoh, Kotaro Tokumoto, Masayuki Inoue …

Nature Communications, 12(6364), Nov 4, 2021 Peer-reviewed
96

Quantifying influence of human choice on the automated detection of Drosophila behavior by a supervised machine learning algorithm

Xubo Leng*, Margot Wohl*, Kenichi Ishii, Pavan Nayak, Kenta Asahina [*Equal contribution]

PLOS ONE, 15(12) e0241696, Dec, 2020 Peer-reviewed
268

Sex-determining genes distinctly regulate courtship capability and target preference via sexually dimorphic neurons

Kenichi Ishii*, Margot Wohl*, Andre DeSouza, Kenta Asahina [*Equal contribution]

eLife, 9 e52701, Apr, 2020 Peer-reviewedLead author
239

Layered roles of fruitless isoforms in specification and function of male aggression-promoting neurons in Drosophila.

Margot Wohl*, Kenichi Ishii*, Kenta Asahina [*Equal contribution]

eLife, 9 e52702, Apr, 2020 Peer-reviewedLead author
Phenotypic and genomic comparisons of highly vancomycin-resistant Staphylococcus aureus strains developed from multiple clinical MRSA strains by in vitro mutagenesis

Kenichi Ishii, Fumiaki Tabuchi, Miki Matsuo, Keita Tatsuno, Tomoaki Sato, Mitsuhiro Okazaki, Hiroshi Hamamoto, Yasuhiko Matsumoto, Chikara Kaito, Tetsuji Aoyagi …

Scientific Reports, 5 17092, Nov, 2015 Peer-reviewedLead author
Antennal RNA-sequencing analysis reveals evolutionary aspects of chemosensory proteins in the carpenter ant, Camponotus japonicus

Masaru K. Hojo*, Kenichi Ishii*, Midori Sakura, Katsushi Yamaguchi, Shuji Shigenobu, Mamiko Ozaki [*Equal contribution]

Scientific Reports, 5 13541, Aug, 2015 Peer-reviewedLead author
Primed Immune Responses Triggered by Ingested Bacteria Lead to Systemic Infection Tolerance in Silkworms

Atsushi Miyashita, Shinji Takahashi, Kenichi Ishii, Kazuhisa Sekimizu, Chikara Kaito

PLOS ONE, 10(6) e0130486, Jun, 2015 Peer-reviewed
Studies of host-pathogen interactions and immune-related drug development using the silkworm: interdisciplinary immunology, microbiology, and pharmacology studies.

Kenichi Ishii, Hiroshi Hamamoto, Kazuhisa Sekimizu

Drug Discoveries & Therapeutics (Review article), 9(4) 238-246, Apr, 2015 Peer-reviewedLead author
Lysocin E is a new antibiotic that targets menaquinone in the bacterial membrane

Hiroshi Hamamoto*, Makoto Urai*, Kenichi Ishii*, Jyunichiro Yasukawa, Atmika Paudel, Motoki Murai, Takuya Kaji, Takefumi Kuranaga, Kenji Hamase, Takashi Katsu …

Nature Chemical Biology, 11(2) 127-133, Feb, 2015 Peer-reviewedLead author
Paralytic Peptide: An Insect Cytokine That Mediates Innate Immunity

Kenichi Ishii, Hiroshi Hamamoto, Kazuhisa Sekimizu

Archives of Insect Biochemistry and Physiology (Review article), 88(1) 18-30, Jan, 2015 Peer-reviewedInvitedLead author
Transgenic silkworms expressing human insulin receptors for evaluation of therapeutically active insulin receptor agonists

Yasuhiko Matsumoto, Masaki Ishii, Kenichi Ishii, Wataru Miyaguchi, Ryo Horie, Yoshinori Inagaki, Hiroshi Hamamoto, Ken-ichiro Tatematsu, Keiro Uchino, Toshiki Tamura …

Biochemical and Biophysical Research Communications, 455(3-4) 159-164, Dec, 2014 Peer-reviewed
Niemann-Pick disease type C2 protein induces triglyceride accumulation in silkworm and mammalian cell lines

Tatsuo Adachi, Kenichi Ishii, Yasuhiko Matsumoto, Yohei Hayashi, Hiroshi Hamamoto, Kazuhisa Sekimizu

Biochemical Journal, 459(1) 137-147, Apr, 2014 Peer-reviewed
Induction of Virulence Gene Expression in Staphylococcus aureus by Pulmonary Surfactant

Kenichi Ishii, Tatsuo Adachi, Jyunichiro Yasukawa, Yutaka Suzuki, Hiroshi Hamamoto, Kazuhisa Sekimizu

Infection and Immunity, 82(4) 1500-1510, Apr, 2014 Peer-reviewedLead author
Identification of a Serratia marcescens virulence factor that promotes hemolymph bleeding in the silkworm, Bombyx mori

Kenichi Ishii, Tatsuo Adachi, Takashi Hara, Hiroshi Hamamoto, Kazuhisa Sekimizu

Journal of Invertebrate Pathology, 117 61-67, Mar, 2014 Peer-reviewedLead author
Establishment of a Bacterial Infection Model Using the European Honeybee, Apis mellifera L.

Kenichi Ishii, Hiroshi Hamamoto, Kazuhisa Sekimizu

PLOS ONE, 9(2) e89917, Feb, 2014 Peer-reviewedLead author
Serratia marcescens suppresses host cellular immunity via the production of an adhesion-inhibitory factor against immunosurveillance cells

Kenichi Ishii, Tatsuo Adachi, Hiroshi Hamamoto, Kazuhisa Sekimizu

Journal of Biological Chemistry, 289(9) 5876-5888, Feb, 2014 Peer-reviewedLead author
Insect cytokine paralytic peptide activates innate immunity via nitric oxide production in the silkworm Bombyx mori

Kenichi Ishii, Tatsuo Adachi, Hiroshi Hamamoto, Tadahiro Oonishi, Manabu Kamimura, Katsutoshi Imamura, Kazuhisa Sekimizu

Developmental and Comparative Immunology, 39(3) 147-153, Mar, 2013 Peer-reviewedLead author

Misc.

Flow zoometry of Drosophila

Walker Peterson, Joshua Arenson, Soichiro Hata, Laura Kacenauskaite, Tsubasa Kobayashi, Takuya Otsuka, Hanqing Wang, Yayoi Wada, Kotaro Hiramatsu, Zhikai He …

bioRxiv, Apr 5, 2024
19

Drosophila epidermal cells are intrinsically mechanosensitive and drive nociceptive behavioral outputs

Jiro Yoshino, Sonali S. Mali, Claire R. Williams, Takeshi Morita, Chloe E. Emerson, Christopher J. Arp, Sophie E. Miller, Chang Yin, Lydia Thé, Chikayo Hemmi …

bioRxiv, 2022.10.07.511265, Oct, 2022
59

Serum proteins potentiate therapeutic efficacy of lysocin E against S. aureus

Kazuhisa Sekimizu, Hiroshi Hamamoto, Suresh Panthee, Atmika Paudel, Kenichi Ishii, Jyunichiro Yasukawa, Su Jie, Hiroaki Itoh, Kotaro Tokumoto, Masayuki Inoue

In Review at Nature journals, Nov 14, 2020
88

A neurogenetic mechanism of experience-dependent suppression of aggression

Kenichi Ishii, Matteo Cortese, Xubo Leng, Maxim N. Shokhirev, Kenta Asahina

bioRxiv, 2020.06.26.172890, Jun 26, 2020 Lead author
97

Quantitative comparison of Drosophila behavior annotations by human observers and a machine learning algorithm

Xubo Leng*, Margot Woh*l, Kenichi Ishii, Pavan Nayak, Kenta Asahina

bioRxiv, 2020.06.16.153130, Jun 16, 2020
カイコをモデル宿主とする自然免疫・感染症研究の最前線 : 昆虫サイトカインParalytic peptide の機能解明を中心に (特集昆虫の生体防御メカニズムのトピックス)

石井健一, 浜本洋, 関水和久

蚕糸・昆虫バイオテック, 84(3) 173-179, Dec, 2015
クロオオアリ触角における化学感覚タンパク質の発現様式と進化

北條賢, 石井健一

BioMedサーカス.com：医学生物学研究の総合ポータルサイト【執筆者自身による研究論文レビュー】, Nov, 2015
Regulation of innate immunity by the insect cytokine paralytic peptide in the silkworm Bombyx mori.

Kenichi Ishii, Hiroshi Hamamoto, Kazuhisa Sekimizu

Seikagaku (Review article in Japanese), 85(12) 1091-1095, Dec, 2013 Lead author

Books and Other Publications

Idenshi meimei monogatari

Satomi Tsuboko, Kenichi Ishii (Role: Joint author)

Chuokoron-shinsha, Inc., Oct, 2021 (ISBN: 9784121507426)

Presentations

A proto-oncogene homolog "nervy" mediates experience-dependent suppression of aggression

Kenichi Ishii, Matteo Cortese, Xubo Leng, Maxim N. Shokhirev, Kazuo Emoto, Kenta Asahina

15th Japan Drosophila Research Conference, Sep 13, 2022
Molecular control of developmental neuronal remodeling in Drosophila neurons

Kotaro Furusawa, Kenichi Ishii, Kazuo Emoto

Neuro2022
Neuronal mechanisms underlying behavioral switching during nociceptive escape

Mami Nakamizo-Dojo, Kenichi Ishii, Kazuo Emoto

Neuro2022, Jul 3, 2022
発達初期における「細切れ睡眠」の制御メカニズムの解明

逸見知世, 石井健一, 榎本和生

日本動物学会関東支部第74回大会, Mar 5, 2022
ショウジョウバエ幼虫における痛覚応答の日内変動

本吉真菜, 石井健一, 榎本和生

日本動物学会関東支部第74回大会, Mar 5, 2022
Protein degradation systems in functional remodeling of Drosophila nociceptive circuits

Kotaro Furusawa, Kenichi Ishii, Kazuo Emoto

44th Annual Meeting of the Japanese Neuroscience Society, Jul 29, 2021 Invited
発達期に特徴的な「細切れ睡眠」の制御メカニズムの解明

逸見知世, 石井健一, 榎本和生

日本動物学会関東支部第73回大会, Mar 20, 2021
nervy acts as an aggression-suppressing gene in octopaminergic/tyraminergic neurons.

Kenichi Ishii, Matteo Cortese, Kenta Asahina

Cold Spring Harbor meeting: Neurobiology of Drosophila, Oct 3, 2019
Fight without Flight: The nervy gene mutation causes hyperaggressive phenotypes in Drosophila

Kenichi Ishii, Kenta Asahina

Evolution 2019, Jun 22, 2019
The Drosophila nervy gene functions in octopaminergic neurons to suppress aggressive behaviors

Kenichi Ishii, Kenta Asahina

Neuroscience 2018 (Society of Neuroscience), Nov 7, 2018
The nervy gene functions in octopaminergic neurons to suppress aggressive behaviors in Drosophila

Kenichi Ishii, Kenta Asahina

Cold Spring Harbor Asia Conferences: Latest Advances in Development & Function of Neuronal Circuits, Sep 27, 2018
The nervy gene acts as a suppressor of aggressive behaviors

Kenichi Ishii, Kenta Asahina

Cold Spring Harbor meeting: Neurobiology of Drosophila, Oct 3, 2017
Identification of nervy as a negative regulator of aggressive behaviors in Drosophila.

Kenichi Ishii, Kenta Asahina

Gordon Research Conference, Neuroethology: Behavior, Evolution & Neurobiology, Jun 18, 2017
Identification of negative regulators for aggressive behaviors in Drosophila.

Kenichi Ishii, Kenta Asahina

Society for Neuroscience (SfN), Neuroscience 2016, Nov 13, 2016
Regulation of innate immune responses by an insect cytokine, paralytic peptide, in the silkworm Bombyx mori.

Kenichi Ishii, Hiroshi Hamamoto, Kazuhisa Sekimizu

1st Asian Invertebrate Immunity Symposium, Feb 15, 2014 Invited

Research Projects

Pain & loneliness: Neural basis for sociality formation through peripheral nociception tuning

Integrated understanding of multi-sensing networks and elucidation of their control mechanisms leading to the innovation of medical technologies (PRIME), Japan Agency for Medical Research and Development (AMED), Oct, 2022 - Mar, 2026

Kenichi Ishii
動物個体間の階層関係を規定する、攻撃制御遺伝子・神経基盤の解明

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2025

Kenichi Ishii
動物個体間の階層関係を規定する社会的不快情動の神経基盤

Leading Initiative for Excellent Young Researchers, Ministry of Education, Culture, Sports, Science and Technology (MEXT), Oct, 2020 - Mar, 2025

Kenichi Ishii
Elucidation of the neural mechanisms underlying sexual dimorphism in aggressive behaviors using Drosophila.

Postdoctoral Fellowships for Research Abroad, Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2018
Establishment of a bacterial infection model in honeybees to elucidate the molecular basis of "social immunity".

Research Fellowships for Young Scientists (PD), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2015
Activation mechanisms of an insect cytokine, paralytic peptide, in the silkworm, Bombyx mori.

Research Fellowships for Young Scientists (DC1), Japan Society for the Promotion of Science, Apr, 2009 - Mar, 2012

Profile Information

Research Interests

Research Areas

Research History

Education

Awards

Papers

Misc.

Books and Other Publications

Presentations

Research Projects

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