Ken-ichi Amemori

J-GLOBAL         Last updated: Oct 29, 2018 at 10:07
 
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Name
Ken-ichi Amemori
Nickname
kenichiamemori
Affiliation
Kyoto University
Degree
PhD
Other affiliation
Massachusetts Institute of Technology
ORCID ID
0000-0001-8500-6820

Profile

A fundamental goal of psychiatry is the ability to control emotion and anxiety. To address this, Ken-ichi developed a behavioral paradigm called, “approach-avoidance conflict,” to quantitatively characterize the value judgment in decision-making. His overarching goal is to identify the causative role of specific brain regions involved in anxiety and emotional conflict by manipulating specific brain circuits in primates and measuring the resulting changes in internal states. He plans to combine physiological, computational and anatomical methods to characterize the anxiety-related network in the cortico-basal ganglia system.

Research Areas

 
 

Academic & Professional Experience

 
 
   
 
Program-Specific Associate Professor, Kyoto University 
 
2017
 - 
Today
Program-Specific Associate Professor, The Hakubi Center for Advanced Research/Primate Research Institute, Kyoto University
 
2017
 - 
Today
Research Affiliate, McGovern Institute for Brain Research, Massachusetts Institute of Technology
 
2009
 - 
2017
Research Scientist, McGovern Institute for Brain Research, Massachusetts Institute of Technology
 
2005
 - 
2009
Postdoctoral Associate/Fellow, McGovern Institute for Brain Research, Massachusetts Institute of Technology
 

Education

 
Apr 1997
 - 
Jun 2001
PhD, Graduate School of Information Science, Nara Institute of Science and Technology
 
Apr 1993
 - 
Mar 1997
Faculty of Integrated Human Studies, Kyoto University
 

Awards & Honors

 
2006
Lynn Diamond Fellow, National Parkinson Foundation
 
2002
Best paper award, Institute of Systems, Control & Information Engineers
Winner: Ken-ichi Amemori, Shin Ishii
 
1999
Best student award, Nara Institute of Science and Technology
 

Published Papers

 
Amemori K, Amemori S, Gibson DJ, Graybiel AM
Neuron   99 829-841   2018   [Refereed]
Dagdeviren C, Ramadi KB, Joe P, Spencer K, Schwerdt HN, Shimazu H, Delcasso S, Amemori K, Nunez-Lopez C, Graybiel AM, Cima MJ, Langer R
Science Translational Medicine   10 eaan2742   2018   [Refereed]
Friedman A, Homma D, Bloem B, Gibb LG, Amemori K, Hu D, Delcasso S, Truong TF, Yang J, Hood AS, Mikofalvy KA, Beck DW, Nguyen N, Nelson ED, Toro Arana SE, Vorder Bruegge RH, Goosens KA, Graybiel AM
Cell   171 1191-1205   2017   [Refereed]
Schwerdt HN, Shimazu H, Amemori K, Amemori S, Tierney PL, Gibson DJ, Hong S, Yoshida T, Langer R, Cima MJ, Graybiel AM
Proceedings of the National Academy of Sciences   114 13260-13265   2017   [Refereed]
Amemori S, Amemori K, Cantor ML, Graybiel AM
Journal of Neuroscience Methods   240 154-160   2015   [Refereed]
Amemori K, Amemori S, Graybiel AM
Journal of Neuroscience   35 1939-1953   2015   [Refereed]
Friedman A, Homma D, Gibb L, Amemori K, Rubin S, Hood A, Riad M, Graybiel AM
Cell   161 1320-1333   2015   [Refereed]
Amemori K, Graybiel AM
Nature Neuroscience   15 776-785   2012   [Refereed]
Feingold J, Desrochers TM, Fujii N, Harlan R, Tierney PL, Shimazu H, Amemori K, Graybiel AM
Journal of Neurophysiology   107 1979-1995   2012   [Refereed]
Fletcher RR, Amemori K, Goodwin M, Graybiel AM
Conf Proc IEEE Engineering in Medicine and Biology Society   4046-4049   2012   [Refereed]
Amemori K, Gibb LG, Graybiel AM
Frontiers in Human Neuroscience   5 47   2011   [Refereed]
Amemori K, Sawaguchi T
European Journal of Neuroscience   23 1895-1909   2006   [Refereed]
Amemori K, Sawaguchi T
Cerebral Cortex   16 1002-1015   2006   [Refereed]
Amemori K, Ishii S
Neurocomputing   61 291-316   2004   [Refereed]
Amemori K, Ishii S
ICANN 2001 Proceedings   361-368   2001   [Refereed]
Amemori K,Ishii S
ICANN 2001 Proceedings   1087-1094   2001   [Refereed]
Amemori K, Ishii S
Neural Computation   13 2763-2797   2001   [Refereed]
Ensemble average and variance of a stochastic spiking neuron model
Amemori K, Ishii S
IEICE Transactions on Fundamentals of Electronics, Communications and Computer Sciences   E83-A 575   2000   [Refereed]
Amemori K, Ishii S
Transactions of the Institute of Systems, Control and Information Engineers   13(7) 308-317   2000   [Refereed]

Misc

 
Computational phenotyping of brain-behavioral relationships underlying approach-avoidance decision making in major depressive disorder
Pedersen ML, Ironside M, McGrath CL, Amemori K, Kang M, Graybiel AM, Frank MJ, Pizzagalli DA
Society for Neuroscience Abstract   320.18    2018
Electrochemical recording of striatal dopamine in non-human primates performing reward-biased tasks
Schwerdt HN, Stanwicks L, Amemori K, Shimazu H, Yoshida T, Amemori S, Langer R, Cima MJ, Graybiel AM
Society for Neuroscience Abstract   701.18    2018
Beta oscillations in the primate striatum predict repetitive negative decision-making states induced by microstimulation
Amemori K, Amemori S, Gibson DJ, Graybiel AM
Society for Neuroscience Abstract   011.01    2018   [Refereed][Invited]
Microstimulation of primate caudate nucleus induces an abnormal repetition of negative decisions predicted by beta oscillatory activity
K Amemori, S Amemori, DJ Gibson, AM Graybiel
The 41st Annual Meeting of the Japan Neuroscience Society      Jul 2018
Microstimulation-recording experiments demonstrate that striosomes in non-human primate control spike activity in the lateral habenula
Hong S, Amemori S, Chung E, Amemori K, Graybiel AM
Society for Neuroscience Abstract   789.11    2017
Rescue and mimicking of chronic stress effects on cost-benefit decision-making by manipulation of a cortico-striosomal circuit
Homma D, Friedman A, Bloem B, Gibb LG, Amemori K, Hu D, Delcasso S, Hood AS, Yang J, Mikofalvy KA, Truong TF, Toro Arena SE, Beck DW, Nguyen N, Vorder Bruegge RH, Nelson ED, Goosens KA, Graybiel AM
Society for Neuroscience Abstract   320.13    2017
Hodgkin-Huxley models of excitatory-inhibitory balance in a cortico-striosomal circuit underlying aberrant cost-benefit decision-making caused by chronic stress
Gibb LG, Friedman A, Homma D, Bloem B, Amemori K, Hu D, Delcasso S, Hood AS, Yang J, Mikofalvy KA, Truong TF, Toro Arena SE, Beck DW, Nguyen N, Vorder Bruegge RH, Nelson ED, Goosens KA, Graybiel AM
Society for Neuroscience Abstract   320.12    2017
A shift in the excitation-inhibition balance of a cortico-striosomal circuit underlies aberrant cost-benefit decision-making caused by chronic stress
Friedman A, Homma D, Bloem B, Gibb LG, Amemori K, Hu D, Delcasso S, Hood AS, Yang J, Mikofalvy KA, Truong TF, Toro Arena SE, Beck DW, Nguyen N, Vorder Bruegge RH, Nelson ED, Goosens KA, Graybiel AM
Society for Neuroscience Abstract   320.14    2017
Electrochemical recording of pharmacologically modulated dopamine from sensors chronically implanted in striatum of awake non-human primates
Schwerdt HN, Shimazu H, Amemori K, Amemori S, Hong S, Yoshida T, Langer R, Cima MJ, Graybiel AM
Society for Neuroscience Abstract   47.15    2017
The neurocircuitry of approach-avoidance decisions in depression: II. Towards a cross species model of utility and motivation
Ironside, M.A., Amemori, K., Kang, M.S, Curry, J., McGrath, C., Etkin, A., Graybiel, A.M., Pizzagalli, D.A.
American College of Neuropsychopharmacology (ACNP)      2017
The neurocircuitry of approach-avoidance decisions in depression: I. Neuroeconomic modeling of reward and utility in decision-making.
Kang, M.S., Ironside, M.A., Amemori, K., Curry, J., Mehta, M., McGrath, C.L., Graybiel, A.M. & Pizzagalli, D.A.
American College of Neuropsychopharmacology (ACNP)   M127    2017
Striatal beta-band oscillations associated with long-lasting pessimistic mood induced by intrastriatal microstimulation
K. Amemori, S. Amemori, D.J. Gibson & A.M. Graybiel
Society for Neuroscience Abstract   168.10   2016
Striosomes may control dopamine activity via disynaptic projections to macaque lateral habenula
S. Hong, S. Amemori, K. Amemori & A.M. Graybiel
Society for Neuroscience Abstract   258.17   2016
Properties of striatal beta oscillation at sites identified by microstimulation as controlling approach-avoidance choice behavior
K. Amemori, S. Amemori, D.J. Gibson & A.M. Graybiel
Society for Neuroscience Abstract   730.21    2015
Compartmental selectivity of a prefronto-striosomal pathway controlling decision-making under motivational conflict
D. Homma, A. Friedman, L.G. Gibb, K. Amemori, S.J. Rubin, A.S. Hood, M.H. Riad & A.M. Graybiel
Society for Neuroscience Abstract   730.20    2015
Striatal high-firing interneurons mediate inhibitory prefrontal-striosomal signaling during cost-benefit conflict decision-making
A. Friedman, D. Homma, L.G. Gibb, K. Amemori, S.J. Rubin, A.S. Hood, M.H. Riad & A.M. Graybiel
Society for Neuroscience Abstract   730.19    2015
A medial prefrontal-striosome circuit is selectively engaged by cost-benefit conflict decision-making
L.G. Gibb, A. Friedman, D. Homma, K. Amemori, S.J. Rubin, A.S. Hood, M.H. Riad & A.M. Graybiel
Society for Neuroscience Abstract   730.18    2015
Fast-scan cyclic voltammetric measurements of stimulation-induced dopamine release with chronically implanted carbon fibers in awake non-human primate
H.N. Schwerdt, H. Shimazu, K. Amemori, S. Hong, J.C. Sy, K.C. Spencer, P.L. Tierney, Y. Yang, H. Yerramreddy, C. Dagdeviren, K. Ramadi, R.S. Langer, M.J. Cima & A.M. Graybiel
Society for Neuroscience Abstract   266.03    2015
Neural responses in striatum related to cost and outcome can drive unsupervised learning in the macaque
Theresa Desrochers, Ken-ichi Amemori, Ann Graybiel
Society for Neuroscience Abstract   342:01    2014
Striatal neuronal activity of macaque tracks local and global changes during natural habit formation
Theresa Desrochers, Ken-ichi Amemori, Ann Graybiel
Cosyne 2014   III-83    2014   [Refereed]

Conference Activities & Talks

 
Searching for a causal role of the primate striatum in repetitive negative decision-making [Invited]
Ken-ichi Amemori
Ishii lab seminar (京都大学情報学研究科)   26 Jun 2018   
Identification of primate emotional circuits controlling anxiety and persistency [Invited]
Ken-ichi Amemori
Conference for Joint Usage (Kyoto University Primate Research Institute)   23 Feb 2018   
Anxiety circuit around cingulate cortex and social neuroscience [Invited]
Ken-ichi Amemori
NIPS Research Meeting (National Institute for Physiological Sciences)   30 Nov 2017   
Control of primate’s decision-making and functional identification of the cortico-striatal circuitry [Invited]
Ken-ichi Amemori
The 7th NIPS / CIN Joint Symposium   28 Nov 2017   
Mapping emotional circuitry by controlling primate's evaluation [Invited]
Ken-ichi Amemori
NIPS Research Meeting (National Institute for Physiological Sciences)   Sep 2017   
Control and functional identification of primate’s anxiety-related cortico-striatal circuitry [Invited]
Ken-ichi Amemori
Neuroscience seminar series (Kyoto University, Graduate School of Medicine)   Jul 2017   
A computational approach to identify the representation and function of cortico-striatal circuit for affective decision-making [Invited]
Ken-ichi Amemori
Ishii lab seminar (Kyoto University)   23 Jun 2017   
Control of primate’s decision-making and functional identification of the brain circuitry [Invited]
Ken-ichi Amemori
Hakubi seminar (Kyoto University)   9 May 2017   
Control of primate brain to regulate anxiety and conflict [Invited]
Ken-ichi Amemori
Primate Research Institute (Kyoto University)   Jan 2017   
Control of primate Cortico-basal ganglia circuit to modulate anxiety and conflict [Invited]
Ken-ichi Amemori
Neuroscience Talk Series (Hokkaido University)   May 2016   

Research Grants & Projects

 
Uehara memorial foundation: Research grant
Project Year: Apr 2018 - Mar 2019    Investigator(s): Ken-ichi Amemori
Brain Science Foundation: Research grant
Project Year: 2018 - 2019    Investigator(s): Ken-ichi Amemori
KAKEN: Grant-in-Aid for Challenging Exploratory Research
Project Year: Sep 2018       Investigator(s): Ken-ichi Amemori
Circuit manipulation
KAKEN: Grant-in-Aid for Scientific Research on Innovative Areas
Project Year: Apr 2018       Investigator(s): Ken-ichi Amemori
Beta oscillation
KAKEN: Grant-in-Aid for Scientific Research on Innovative Areas
Project Year: Apr 2018       Investigator(s): Ken-ichi Amemori