2017年11月16日
Chronic Stress Alters Striosome-Circuit Dynamics, Leading to Aberrant Decision-Making.
Cell
- 巻
- 171
- 号
- 5
- 開始ページ
- 1191
- 終了ページ
- 1205
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.cell.2017.10.017
Effective evaluation of costs and benefits is a core survival capacity that in humans is considered as optimal, "rational" decision-making. This capacity is vulnerable in neuropsychiatric disorders and in the aftermath of chronic stress, in which aberrant choices and high-risk behaviors occur. We report that chronic stress exposure in rodents produces abnormal evaluation of costs and benefits resembling non-optimal decision-making in which choices of high-cost/high-reward options are sharply increased. Concomitantly, alterations in the task-related spike activity of medial prefrontal neurons correspond with increased activity of their striosome-predominant striatal projection neuron targets and with decreased and delayed striatal fast-firing interneuron activity. These effects of chronic stress on prefronto-striatal circuit dynamics could be blocked or be mimicked by selective optogenetic manipulation of these circuits. We suggest that altered excitation-inhibition dynamics of striosome-based circuit function could be an underlying mechanism by which chronic stress contributes to disorders characterized by aberrant decision-making under conflict. VIDEO ABSTRACT.
- リンク情報
- ID情報
-
- DOI : 10.1016/j.cell.2017.10.017
- ORCIDのPut Code : 68193537
- PubMed ID : 29149606
- PubMed Central 記事ID : PMC5734095
- SCOPUS ID : 85034116406