2018年4月17日
Expression of KK-LC-1, a cancer/testis antigen, at non-tumour sites of the stomach carrying a tumour.
Scientific reports
- 巻
- 8
- 号
- 1
- 開始ページ
- 6131
- 終了ページ
- 6131
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/s41598-018-24514-9
- 出版者・発行元
- Nature Publishing Group
Kita-Kyushu lung cancer antigen-1 (KK-LC-1) is a cancer/testis antigen (CTA) and predominant target for cancer immunotherapy. Our previous study indicated that KK-LC-1 was expressed in 82% of gastric cancers, and also in 79% of early stage of gastric cancers, with a correlation to Helicobacter pylori (H. pylori) infection. In addition, we found that KK-LC-1 was occasionally expressed at non-tumour sites of stomachs carrying tumours. Here, we investigated the characteristics of KK-LC-1 expression at non-tumour sites and the clinical utility of these phenomena. The gene expression of KK-LC-1 was detected at the non-tumour sites including pyloric glands. The most detectable corpus/gland subset had a KK-LC-1 expression rate of 77% in the pyloric gland of the lower corpus where H. pylori preferentially exists. KK-LC-1 expression rates were 67% or 32% with or without intestinal metaplasia, which also induced by H. pylori, respectively. Consequently, KK-LC-1 would be detected at the pre-cancerous condition of the stomach, and may be a useful marker to predict gastric cancer.
- リンク情報
- ID情報
-
- DOI : 10.1038/s41598-018-24514-9
- ISSN : 2045-2322
- ORCIDのPut Code : 76918378
- PubMed ID : 29666402
- PubMed Central 記事ID : PMC5904109
- SCOPUS ID : 85045755823