Kenichi KIMURA

Profile Information

Affiliation: Assistant Professor, Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba

ORCID iD: https://orcid.org/0000-0002-0363-8865
J-GLOBAL ID: 202001020034855177
researchmap Member ID: R000004246

Research Interests

Research Areas

Research History

Apr, 2020 - Present

Assistant Professor, Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba
Sep, 2012 - Mar, 2020

Postdoctoral Reseacher, University of Bonn, Institute of Physiology I
Apr, 2012 - Aug, 2012

ポスドク研究員, 筑波大学医学医療系

Education

Apr, 2008 - Mar, 2012

筑波大学人間総合科学研究科生命システム医学専攻

Committee Memberships

Nov, 2024 - Present

代議員, 日本再生医療学会
Nov, 2022 - Present

若手の会/代表, 日本結合組織学会
Nov, 2022 - Present

若手の会/幹事, 日本結合組織学会
Aug, 2022 - Present

チームU45/サブメンバー, 日本再生医療学会

Awards

Papers

Fibrillin-1 G234D mutation in the hybrid1 domain causes tight skin associated with dysregulated elastogenesis and increased collagen cross-linking in mice

Hossain, ASM Sakhawa, Clarin, Maria Thea, Rane, Dela Cruz, Kimura, Kenichi, Biggin, George, Taga, Yuki, Uto, Koichiro …

MATRIX BIOLOGY, 135 24-38, Feb, 2025 Peer-reviewed
descSPIM: an affordable and easy-to-build light-sheet microscope optimized for tissue clearing techniques

Otomo, Kohei, Omura, Takaki, Nozawa, Yuki, Edwards, Steven J, Sato, Yukihiko, Saito, Yuri, Yagishita, Shigehiro, Uchida, Hitoshi, Watakabe, Yuki …

Nature communications, 15(1) 4941, Jun, 2024 Peer-reviewed
A novel genetic mouse model of fatal aortic dissection reveals massive inflammatory cell infiltration in the thoracic aorta

Kimura, Kenichi, Motoyama, Eri, Kanki, Sachiko, Asano, Keiichi, Sheikh, Md Al Amin, Clarin, Maria Thea, Rane, Dela Cruz, Raja, Erna …

Biorxiv, May, 2024 Lead authorCorresponding author
Bone marrow CD73+ mesenchymal stem cells display increased stemness in vitro and promote fracture healing in vivo

Kenichi Kimura, Martin Breitbach, Frank A. Schildberg, Michael Hesse, Bernd K. Fleischmann

Bone Reports, 15 101133-101133, Dec, 2021 Peer-reviewedLead authorCorresponding author
Overexpression of human BAG3P209L in mice causes restrictive cardiomyopathy.

Kenichi, Kimura, Astrid, Ooms, Kathrin, Graf-Riesen, Maithreyan, Kuppusamy, Andreas, Unger, Julia, Schuld, Jan, Daerr, Achim, Lother, Caroline, Geisen, Lutz, Hein …

Nature Communications, Jun, 2021 Peer-reviewedLead author
Contribution of PDGFRα-positive cells in maintenance and injury responses in mouse large vessels

Kenichi Kimura, Karina Ramirez, Tram Anh Vu Nguyen, Yoshito Yamashiro, Aiko Sada, Hiromi Yanagisawa

Scientific Reports, 11(1) 8683-8683, Apr, 2021 Peer-reviewedLead author
Tetrahydroimidazo[1,2-a]pyrazine Derivatives: Synthesis and Evaluation As Gαq-Protein Ligands.

Michael Gütschow, Jim Küppers, Tobias Benkel, Suvi Annala, Kenichi Kimura, Lisa Reinelt, Bernd K Fleischmann, Evi Kostenis

Chemistry (Weinheim an der Bergstrasse, Germany), May 19, 2020 Peer-reviewed
PECAM/eGFP transgenic mice for monitoring of angiogenesis in health and disease.

Florian Winkler, Katia Herz, Sarah Rieck, Kenichi Kimura, Tianyuan Hu, Wilhelm Röll, Michael Hesse, Bernd K Fleischmann, Daniela Wenzel

Scientific reports, 8(1) 17582-17582, Dec 4, 2018 Peer-reviewed
Midbody Positioning and Distance Between Daughter Nuclei Enable Unequivocal Identification of Cardiomyocyte Cell Division in Mice.

Michael Hesse, Michael Doengi, Alexandra Becker, Kenichi Kimura, Nadine Voeltz, Valentin Stein, Bernd K Fleischmann

Circulation research, 123(9) 1039-1052, Oct 12, 2018 Peer-reviewed
Overexpression of Cx43 in cells of the myocardial scar: Correction of post-infarct arrhythmias through heterotypic cell-cell coupling.

Wilhelm Roell, Alexandra M Klein, Martin Breitbach, Torsten S Becker, Ashish Parikh, Jane Lee, Katrin Zimmermann, Shaun Reining, Beth Gabris, Annika Ottersbach …

Scientific reports, 8(1) 7145-7145, May 8, 2018 Peer-reviewed
In Vivo Labeling by CD73 Marks Multipotent Stromal Cells and Highlights Endothelial Heterogeneity in the Bone Marrow Niche.

Martin Breitbach, Kenichi Kimura, Tiago C Luis, Christopher J Fuegemann, Petter S Woll, Michael Hesse, Raffaella Facchini, Sarah Rieck, Katarzyna Jobin, Julia Reinhardt …

Cell stem cell, 22(2) 262-276, Feb 1, 2018 Peer-reviewedLead author
Elevated Expression of Dkk-1 by Glucocorticoid Treatment Impairs Bone Regenerative Capacity of Adipose Tissue-Derived Mesenchymal Stem Cells.

Toshiki Kato, Vuong Cat Khanh, Kazutoshi Sato, Kenichi Kimura, Toshiharu Yamashita, Hisashi Sugaya, Tomokazu Yoshioka, Hajime Mishima, Osamu Ohneda

Stem cells and development, 27(2) 85-99, Jan 15, 2018 Peer-reviewed
Increased Expression of EGR-1 in Diabetic Human Adipose Tissue-Derived Mesenchymal Stem Cells Reduces Their Wound Healing Capacity.

Nhu-Thuy Trinh, Toshiharu Yamashita, Kinuko Ohneda, Kenichi Kimura, Georgina To'a Salazar, Fujio Sato, Osamu Ohneda

Stem cells and development, 25(10) 760-73, May 15, 2016 Peer-reviewed
A Chemokine Receptor, CXCR4, Which Is Regulated by Hypoxia-Inducible Factor 2α, Is Crucial for Functional Endothelial Progenitor Cells Migration to Ischemic Tissue and Wound Repair.

Tran Cam Tu, Masumi Nagano, Toshiharu Yamashita, Hiromi Hamada, Kinuko Ohneda, Kenichi Kimura, Osamu Ohneda

Stem cells and development, 25(3) 266-76, Feb 1, 2016 Peer-reviewed
Impaired expression of HIF-2α induces compensatory expression of HIF-1α for the recovery from anemia.

Ikki Tsuboi, Toshiharu Yamashita, Masumi Nagano, Kenichi Kimura, Georgina To'a Salazar, Osamu Ohneda

Journal of cellular physiology, 230(7) 1534-48, Jul, 2015 Peer-reviewed
Hypoxia-inducible factor-3α promotes angiogenic activity of pulmonary endothelial cells by repressing the expression of the VE-cadherin gene.

Satomi Kobayashi, Toshiharu Yamashita, Kinuko Ohneda, Masumi Nagano, Kenichi Kimura, Hideto Nakai, Lorenz Poellinger, Osamu Ohneda

Genes to cells : devoted to molecular & cellular mechanisms, 20(3) 224-41, Mar, 2015 Peer-reviewed
Dual functions of hypoxia-inducible factor 1 alpha for the commitment of mouse embryonic stem cells toward a neural lineage.

Yang Zhao, Mami Matsuo-Takasaki, Ikki Tsuboi, Kenichi Kimura, Georgina To'a Salazar, Toshiharu Yamashita, Osamu Ohneda

Stem cells and development, 23(18) 2143-55, Sep 15, 2014 Peer-reviewed
The role of CCL5 in the ability of adipose tissue-derived mesenchymal stem cells to support repair of ischemic regions.

Kenichi Kimura, Masumi Nagano, Georgina Salazar, Toshiharu Yamashita, Ikki Tsuboi, Hajime Mishima, Shonosuke Matsushita, Fujio Sato, Kenji Yamagata, Osamu Ohneda

Stem cells and development, 23(5) 488-501, Mar 1, 2014 Peer-reviewedLead author
Functional endothelial progenitor cells selectively recruit neurovascular protective monocyte-derived F4/80(+) /Ly6c(+) macrophages in a mouse model of retinal degeneration.

Shinichi Fukuda, Masumi Nagano, Toshiharu Yamashita, Kenichi Kimura, Ikki Tsuboi, Georgina Salazar, Shinji Ueno, Mineo Kondo, Tilo Kunath, Tetsuro Oshika …

Stem cells (Dayton, Ohio), 31(10) 2149-61, Oct, 2013 Peer-reviewed
Umbilical cord blood-derived mesenchymal stem cells inhibit, but adipose tissue-derived mesenchymal stem cells promote, glioblastoma multiforme proliferation.

Keiko Akimoto, Kenichi Kimura, Masumi Nagano, Shingo Takano, Georgina To'a Salazar, Toshiharu Yamashita, Osamu Ohneda

Stem cells and development, 22(9) 1370-86, May 1, 2013 Peer-reviewed

Misc.

ステロイド性大腿骨頭壊死における間葉系幹細胞の骨再生に与える影響

加藤俊貴, CAT Khanh Vuong, 佐藤和聡, 木村健一, 山下年晴, 菅谷久, 菅谷久, 吉岡友和, 吉岡友和, 三島初 …

再生医療, 16, 2017
ステロイド薬投与が間葉系幹細胞の骨再生に与える影響の解析

加藤俊貴, 佐藤和聡, 木村健一, 山下年晴, 菅谷久, 菅谷久, 吉岡友和, 吉岡友和, 三島初, 大根田修

再生医療, 15, 2016
ステロイド薬投与が間葉系幹細胞の骨再生に与える影響の解析

加藤俊貴, 加藤俊貴, 佐藤和聡, 木村健一, 山下年晴, 菅谷久, 菅谷久, 吉岡友和, 吉岡友和, 三島初 …

日本生化学会大会(Web), 88th, 2015
A Chemokine Receptor CXCR4 Plays a Crucial Role for Repairing Ischemic Tissue through Regulation of HIF-2a

Masumi Nagano, Ken-ichi Kimura, Toshiharu Yamashita, Hiromi Hamada, Kinuko Ohneda, Hiroyuki Yoshikawa, Osamu Ohneda

BLOOD, 112(11) 1336-1337, Nov, 2008 Peer-reviewed

Books and Other Publications

心臓

木村, 健一, 柳沢裕美 (Role: Contributor, 大動脈瘤への分子生物学的アプローチ)

日本医学出版, Jun, 2022

Presentations

Transformation of enteroendocrine cell identity by the stress-inducible transcription factor Xrp1

Qian, Qingyin, Hayashi, Makoto, Nagai, Hiroki, Sanaki, Yuya, Kimura, Kenichi, Kobayashi, Satoru, Nakajima, Yuichiro, NIWA, Ryusuke

66th Annual Drosophila Research Conference
Anti-inflammatory Nanoparticles as Potential Treatment for Aortic Dissection

Clarin, M.T.R.D.C., Motoyama, Eri, A., Nabil, Kanki, Sachiko, Uto, Koichiro, Kimura, Kenichi, H., Yanagisawa, Ebara, Mitsuhiro

つくば医工連携フォーラム2025
遺伝性胸部大動脈疾患におけるメカノトランスダクション異常

柳沢裕美, 木村健一, 本山絵理, 浅野恵一, 神吉佐知子

CVMW 2024
Phenotypic changes of endothelial cells in the pathogenesis of aortic dissection.

Kimura, Kenichi, Motoyama, Eri, Kanki, Sachiko, Asano, Keiichi, Sheikh, Md Al Amin, Deleeuw, Violette, Sips, Patrick, Backer, Julie De, Sakai, Lynn Y., Yanagisawa, Hiromi

CVMW 2024
Elucidating the Role of Anti-aging Matrix Fibulin 7 in Skin Inflammatory Disease Psoriasis

ERNA, Raja, Watanabe, Yukihide, Kimura, Kenichi, Yanagisawa, Hiromi

The 49th Annual Meeting of the Japanese Society for Investigative Dermatology
骨髄ニッチにおけるミクロフィブリルを介した造血制御機構の解明

木村, 健一, 本山絵理, 神吉佐知子, 柳沢裕美

第8回エラスチン・関連分子研究会
フィブリリン１遺伝子変異による大動脈解離病態に関わる血管内皮細胞の機能解析

本山絵理, 木村, 健一, 浅野恵一, 神吉佐知子, 中邨智之, 柳沢裕美

第8回エラスチン・関連分子研究会
A stress-responsive transcriptional factor drives fate conversion of enteroendocrine cells in Drosophila melanogaster

Qian, Qingyin, Hayashi, Makoto, Nagai, Hiroki, Kimura, Ken-ichi, Kobayashi, Satoru, Nakajima, Yuichiro, NIWA, Ryusuke

第47回日本分子生物学会年会
Phenotypic changes of endothelial cells in the pathogenesis of aortic dissection.

Kimura, Kenichi, Motoyama, Eri, Kanki, Sachiko, Asano, Keiichi, Sheikh, Md Al Amin, Deleeuw, Violette, Sips, Patrick, Backer, Julie De, Sakai, Lynn Y., Yanagisawa, Hiromi

第47回日本分子生物学会年会
軟骨組織におけるCD73陽性細胞の細胞系譜解析

Sanaki-Matsumiya, Marina, Hosomi, Nao, Yanagisawa, Hiromi, Kimura, Kenichi

第47回日本分子生物学会年会
Anti-inflammatory Nanoparticles as Potential Treatment for Aortic Dissection

Clarin, M.T.R.D.C., Motoyama, Eri, A., Nabil, Kanki, Sachiko, Uto, Koichiro, Kimura, Kenichi, H., Yanagisawa, Ebara, Mitsuhiro

NIMS Award Symposium
Nanoparticles as a potential therapeutic tool for targeting M1 macrophages in Aortic Dissection

Clarin, M.T.R.D.C., Motoyama, Eri, A., Nabil, Kanki, Sachiko, Uto, Koichiro, Kimura, Kenichi, Ebara, Mitsuhiro, H., Yanagisawa

Tsukuba Global Science Week 2024
Investigation of the molecular pathogenesis of aortic dissection in new Fibrillin 1 mutant mice by synchrotron imaging and transcriptomics analysis

Sheikh, Md Al Amin, Kimura, Kenichi, Motoyama, Eri, Deleeuw, Violette, Kanki, Sachiko, Asano, Keiichi, Sips, Patrick, Backer, Julie De, Sakai, Lynn Y., Ozaki, Haruka, Yanagisawa, Hiromi

Tsukuba Global Science Week 2024
Role of CD73-lineage cells in articular cartilage degeneration and remodeling in osteoarthritis

Hosomi, Nao, Matsumiya, Marina, Yanagisawa, Hiromi, Kimura, Kenichi

Tsukuba Global Science Week 2024
Converting one differentiated cell identity into another: Insights from Drosophila enteroendocrine cells

Qian, Qingyin, Hayashi, Makoto, Nagai, Hiroki, Kimura, Ken-ichi, Kobayashi, Satoru, Yanagisawa, Hiromi, Nakajima, Yuichiro, NIWA, Ryusuke

The 16th Japanese Drosophila Research Conference (JDRC16)
新規Fibrillin-1点変異マウスモデルを⽤いた⼤動脈解離発症機序の解明

木村, 健一

第10回MatriCellフォーラム
CELL LINEAGE ANALYSIS OF CD73-POSITIVE CELLS IN OSTEOCHONDRAL TISSUE

Kimura, Kenichi, Ishi, Ryutaro, Yanagisawa, Hiromi

The International Society for Stem Cell Research 2024
A Smart Nanofiber-based Therapeutic Approach for Aortic Dissection by Targeting Sympathetic Innervation

LI, Kai, Chen, Lili, Fujisawa, Nanami, Kimura, Kenichi, Motoyama, Eri, Yanagisawa, Hiromi, Ebara, Mitsuhiro

The 40th annual meeting of JSDDS
Development of nanoparticles to induce M1-to-M2 switch as a treatment for aortic dissection in Fbn1 mutant mice.

Clarin, M.T.R.D.C, E., Motoyama, A., Nabil, S., Kanki, Uto, Koichiro, Kimura, Kenichi, Ebara, Mitsuhiro, H., Yanagisawa

International Vascular Biology Meeting 2024
Phenotypic changes of endothelial cells in the pathogenesis of aortic dissection.

Kimura, Kenichi, Motoyama, Eri, Kanki, Sachiko, Asano, Keiichi, Sheikh, Md Al Amin, Deleeuw, Violette, Sips, Patrick, Backer, Julie De, Sakai, Lynn Y, Yanagisawa, Hiromi

International Vascular Biology Meeting 2024

Teaching Experience

Oct, 2020 - Present

血管生物学のトピックス (筑波大学)
2020 - Present

医科学セミナーV(キャリアパス) (筑波大学)
2020 - Present

アドヴァンストコース (筑波大学)
2020 - Present

Research presentation and Discussion (筑波大学)
Oct, 2022 - Feb, 2023

Medical Science Seminar V: Career Path (University of Tsukuba.)
Oct, 2022 - Feb, 2023

Special Practice in Human Biology II (University of Tsukuba.)
Oct, 2022 - Dec, 2022

腫瘍学 (筑波大学)
Apr, 2022 - Aug, 2022

Medical Science Seminar V: Career Path (University of Tsukuba.)
Apr, 2022 - Aug, 2022

Special Practice in Human Biology II (University of Tsukuba.)
Oct, 2021 - Feb, 2022

Medical Science Seminar V: Career Path (University of Tsukuba.)
Oct, 2021 - Dec, 2021

Topics in Vascular Biology (University of Tsukuba.)
Apr, 2021 - Aug, 2021

Medical Science Seminar V: Career Path (University of Tsukuba.)

Professional Memberships

Mar, 2006 - Present

日本再生医療学会
Jun, 2011 - Present

国際幹細胞学会
2012 - 2020

ドイツ生理学会
2021 - Present

日本生化学会
2021 - Present

日本血管生物医学会
2021 - Present

日本循環器学会
2021 - Present

The Molecular Biology Society of Japan
2022 - Present

日本結合組織学会

Research Projects

ミクロフィブリル変異による骨髄ニッチ恒常性異常と大動脈疾患へ及ぼす影響の解明

Apr, 2024 - Mar, 2029

木村健一
変形関節症における軟骨変性メカニズムの解明

2023年度医学系研究助成（基礎）, 武田科学振興財団, Jul, 2023 - Mar, 2028

木村健一
細胞外マトリクスを基軸とした胸部大動脈疾患の発生機序の解明と新規治療法の開発

科学研究費補助金基盤研究（A）, 日本学術振興会, Apr, 2023 - Mar, 2027

柳沢裕美
腸内細菌叢が織りなす大動脈疾患の新たな制御機構の解明

一般研究助成, 公益財団法人ヤクルト・バイオサイエンス研究財団, Apr, 2025 - Mar, 2026

木村健一
内在性間葉系幹細胞を用いた変形性関節症治療のための再生医療基盤の開発

「再生・細胞医療・遺伝子治療実現加速化プログラム（再生・細胞医療・遺伝子治療研究開発課題（基礎応用研究課題））」, 日本医療研究開発機構, Jul, 2023 - Mar, 2026

木村健一杉山夏緒里
CD73陽性細胞による骨髄造血微小環境形成メカニズムの解明

稲盛研究助成, 稲盛財団, Apr, 2023 - Mar, 2025

木村健一
細胞系譜解析を用いたCD73発現細胞による骨髄ニッチ形成および骨修復機構の解明

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025

木村健一
Elucidation of the pathogenesis of aortic dissection caused by the alteration in microfibrils

Grants-in-Aid for Scientific Research, Fund for the Promotion of Joint International Research (Fostering Joint International Research (B)), Japan Society for the Promotion of Science, Oct, 2021 - Mar, 2025
CD73発現細胞による骨髄微小環境の細胞ダイナミクスの解明

第35回ノバルティス研究奨励金, ノバルティス科学振興財団, Apr, 2022 - Mar, 2023
微小発現解析による大動脈解離の新規バイオマーカーの探索

2021年度研究助成金, かなえ医薬振興財団, Nov, 2021 - Mar, 2023

木村健一
細胞系譜解析から紐解く骨髄微小環境形成機構の解明

2020年度研究奨励金, 上原記念生命科学財団, Jan, 2021 - Apr, 2022

木村健一
細胞系譜解析を用いた骨髄造血微小環境の形成メカニズムの解明

令和2年度若手研究者助成, 先進医薬研究振興財団, Dec, 2020 - Dec, 2021

木村健一
細胞系譜解析から紐解く骨髄造血微小環境の形成機構の解明

2020年度研究助成, テルモ生命科学振興財団, Dec, 2020 - Dec, 2021

木村健一

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Research Interests

Research Areas

Research History

Education

Committee Memberships

Awards

Papers

Misc.

Books and Other Publications

Presentations

Teaching Experience

Professional Memberships

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