Kenji Mizuseki

J-GLOBAL         Last updated: Aug 2, 2019 at 13:51
Kenji Mizuseki
Osaka City University
Graduate School of Medicine Basic Medicine Course
M.D., Ph.D.(Kyoto University)
Research funding number


Coordinated patterns of neural activity spanning broad spatial and temporal scales underlie information processing in the brain. How are these activity patterns generated by intrinsic cellular properties, synaptic interactions, neuromodulatory systems, and network dynamics? How do these activity patterns carry out computational tasks that the brain attempts to perform? How are internally generated, self-organized network activities perturbed by the external world to produce perception and memory? Our goal is to quantitatively characterize and mechanistically explain information processing in terms of neuronal activity dynamics. Possible mechanisms subserving these processes include precisely structured sequences of activity, synchrony within and across brain regions, and dynamic grouping of local and global neuronal assemblies by network oscillations. These possibilities are testable only if we can simultaneously monitor the activities of many neurons and local field potentials in multiple regions of the intact brain at relevant time resolutions. To achieve our goal, we will employ large-scale electrophysiological recordings of neuronal ensembles in the hippocampus and its related structures in rats and mice while they perform various tasks and while at rest. In addition, we combine in vivo electrophysiology and optogenetics to elucidate pathway- and cell type-specific functions in information processing.

Research Areas


Academic & Professional Experience

Apr 2015
Professor, Department of Physiology, Osaka City University Graduate School of Medicine
Sep 2012
Mar 2015
Senior Scientist, Neural Coding, Allen Institute for Brain Science
Mar 2012
Sep 2012
Research Assistant Professor, New York University School of Medicine
Mar 2009
Mar 2012
Research Assistant Professor, Center for Molecular and Behavioral Neuroscience, Rutgers University
Apr 2004
Feb 2009
Postdoctoral Fellow, Center for Molecular and Behavioral Neuroscience, Rutgers University
Feb 2002
Mar 2004
Research Scientist, RIKEN, Center for Developmental Biology
Apr 2000
Jan 2002
Japan Society for the Promotion of Scinece, Research Fellowship for Young Scientists, Institute for Frontier Medical Sciences, Kyoto University


Apr 1996
Mar 2000
Graduate School of Medicine, Kyoto University
Apr 1990
Mar 1996
Faculty of Medicine, Kyoto University

Published Papers

Watanabe K, Sasaki AT, Tajima K, Mizuseki K, Mizuno K, *Watanabe Y
Scientific reports   9(8789) 1-8   Jun 2019   [Refereed]
Matsumoto N, *Kitanishi T, Mizuseki K
Neuroscience Research   143 1-12   Jun 2019   [Refereed]
Watanabe K, Nozaki S, Goto M, Kaneko KI, Hayashinaka E, Irie S, Nishiyama A, Kasai K, Fujii K, Wada Y, Mizuno K, Mizuseki K, Doi H, *Watanabe Y
Biochemical and biophysical research communications   512 611-615   May 2019   [Refereed]
Giri B, Miyawaki H, Mizuseki K, Cheng S, *Diba K
The Journal of Neuroscience   39 866-875   Jan 2019   [Refereed]
Kobayashi R, Kurita S, Kitano K, Mizuseki K, Richmond BJ, *Shinomoto S
bioRxiv   334078   Jan 2018
*Mizuseki K, Miyawaki H
Neuroscience research   118 30-47   May 2017   [Refereed]
Kitanishi T, Ito HT, Hayashi Y, Shinohara Y, *Mizuseki K, *Hikida T
The journal of physiological sciences : JPS   67(2) 247-258   Mar 2017   [Refereed]
Durand S, Iyer R, Mizuseki K, de Vries S, Mihalas S, *Reid RC
The Journal of Neuroscience   36(48) 12144-12156   Nov 2016   [Refereed]
Diba K, Amarasingham A, Mizuseki K, *Buzsáki G
The Journal of Neuroscience : the official journal of the Society for Neuroscience   34(45) 14984-14994   Nov 2014   [Refereed]
Schomburg EW, Fernández-Ruiz A, Mizuseki K, Berényi A, Anastassiou CA, Koch C, *Buzsáki G
Neuron   84(2) 470-485   Oct 2014   [Refereed]


Multiple single unit recordings from different rat hippocampal and entorhinal regions while the animals were performing multiple behavioral tasks
Mizuseki K, Sirota, Pastalkova E, Diba K, Buzsáki G      2014

Books etc

Handbook of Sleep Research
Mizuseki K, Miyawaki H (Part:Contributor, Chapter 7. Hippocampal information processing and homeostatic regulation during REM and non-REM Sleep)
Academic Press/Elsevier   Aug 2019   

Conference Activities & Talks

Pathway-specific information processing in the subiculum across sleep/wake cycles. [Invited]
Kenji Mizuseki
Annual Meeting of the Japan Neuroscience Society   27 Jul 2019   
Regulation of neuronal excitability by REM sleep
Kenji Mizuseki
Grant-in-Aid for Scientific Research on Innovative Areas, “Principles of memory dynamism elucidated from a diversity of learning systems” 2018 workshop and Meeting   7 Mar 2018   
Temporal coordination of neuronal activity in the entorhinal-hippocampal loop [Invited]
Kenji Mizuseki
The 4th CiNet Conference - Functional and anatomical connectivity, Center for Information and Neural Networks (CiNet)   28 Feb 2018   
Hippocampal CA1 pyramidal cells form functionally distinct sublayers. [Invited]
Kenji Mizuseki
The Japan Neuroscience Society, Symposium “Network dissection of hippocampal function”   20 Jul 2016   The Japan Neuroscience Society
Temporal coordination of neuronal activity in the entorhinal-hippocampal circuit [Invited]
Kenji Mizuseki
Korea Institute of Science and Technology Seminar   20 Apr 2016