2017年4月
Long-term outcomes of colorectal endoscopic submucosal dissection in elderly patients
International Journal of Colorectal Disease
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- 巻
- 32
- 号
- 4
- 開始ページ
- 567
- 終了ページ
- 573
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1007/s00384-016-2719-y
- 出版者・発行元
- Springer Science and Business Media LLC
BACKGROUND AND AIMS: The safety and efficacy of endoscopic submucosal dissection (ESD) in elderly patients remain unclear. The aim of this study is to clarify the short- and long-term outcomes of colorectal ESD in elderly patients. PATIENTS AND METHODS: A total of 482 consecutive patients with 501 colorectal lesions treated with ESD from February 2005 to December 2013 were retrospectively reviewed. Patients were divided into two groups: an elderly group (≥ 75 years of age) and a non-elderly group (< 75 years of age). Short-term outcomes of interest were procedure time, complication rate, hospital stay, en bloc resection rate, and non-curative resection rate. Long-term outcomes of interest were disease-specific survival, and overall survival rates in the elderly group (51 patients) and non-elderly group (92 patients) were also analyzed. RESULTS: No significant differences were observed between the groups with respect to short-term outcomes. Two patients in each group required emergency surgery. Of the patients who underwent non-curative resection, 7/12 (58%) in the elderly group and 15/23 (65%) in the non-elderly group underwent additional surgery. The 5-year disease-specific survival rates in the elderly and non-elderly groups were both 100%, and the corresponding 5-year overall survival rates were 86.3 and 93.5%, respectively (p = 0.026). CONCLUSIONS: Short-term outcomes after colorectal ESD were equivalent in both groups, and all patients showed favorable long-term outcomes. Considering the benign prognosis of lesions resected with ESD, preoperative screening of comorbidities is essential to improve overall survival.
- リンク情報
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- DOI
- https://doi.org/10.1007/s00384-016-2719-y
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/27900464
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355509
- URL
- http://link.springer.com/content/pdf/10.1007/s00384-016-2719-y.pdf
- URL
- http://link.springer.com/article/10.1007/s00384-016-2719-y/fulltext.html
- ID情報
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- DOI : 10.1007/s00384-016-2719-y
- ISSN : 0179-1958
- eISSN : 1432-1262
- PubMed ID : 27900464
- PubMed Central 記事ID : PMC5355509