2016年
Metabolic Regulation of Apoptosis in Cancer
INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY, VOL 327
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- ,
- ,
- 巻
- 327
- 号
- 開始ページ
- 43
- 終了ページ
- 87
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/bs.ircmb.2016.06.006
- 出版者・発行元
- ELSEVIER ACADEMIC PRESS INC
Apoptosis is a cellular suicide program that plays a critical role in development and human diseases, including cancer. Cancer cells evade apoptosis, thereby enabling excessive proliferation, survival under hypoxic conditions, and acquired resistance to therapeutic agents. Among various mechanisms that contribute to the evasion of apoptosis in cancer, metabolism is emerging as one of the key factors. Cellular metabolites can regulate functions of pro-and antiapoptotic proteins. In turn, p53, a regulator of apoptosis, also controls metabolism by limiting glycolysis and facilitating mitochondrial respiration. Consequently, with dysregulated metabolism and p53 inactivation, cancer cells are well-equipped to disable the apoptotic machinery. In this article, we review how cellular apoptosis is regulated and how metabolism can influence the signaling pathways leading to apoptosis, especially focusing on how glucose and lipid metabolism are altered in cancer cells and how these alterations can impact the apoptotic pathways.
- リンク情報
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- DOI
- https://doi.org/10.1016/bs.ircmb.2016.06.006
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/27692180
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819894
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000394566900002&DestApp=WOS_CPL
- URL
- http://europepmc.org/abstract/med/27692180
- URL
- http://orcid.org/0000-0003-4612-6031
- ID情報
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- DOI : 10.1016/bs.ircmb.2016.06.006
- ISSN : 1937-6448
- ORCIDのPut Code : 45669884
- PubMed ID : 27692180
- PubMed Central 記事ID : PMC5819894
- Web of Science ID : WOS:000394566900002