MISC

招待有り
2016年

Metabolic Regulation of Apoptosis in Cancer

INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY, VOL 327
  • K. Matsuura
  • ,
  • K. Canfield
  • ,
  • W. Feng
  • ,
  • M. Kurokawa

327
開始ページ
43
終了ページ
87
記述言語
英語
掲載種別
DOI
10.1016/bs.ircmb.2016.06.006
出版者・発行元
ELSEVIER ACADEMIC PRESS INC

Apoptosis is a cellular suicide program that plays a critical role in development and human diseases, including cancer. Cancer cells evade apoptosis, thereby enabling excessive proliferation, survival under hypoxic conditions, and acquired resistance to therapeutic agents. Among various mechanisms that contribute to the evasion of apoptosis in cancer, metabolism is emerging as one of the key factors. Cellular metabolites can regulate functions of pro-and antiapoptotic proteins. In turn, p53, a regulator of apoptosis, also controls metabolism by limiting glycolysis and facilitating mitochondrial respiration. Consequently, with dysregulated metabolism and p53 inactivation, cancer cells are well-equipped to disable the apoptotic machinery. In this article, we review how cellular apoptosis is regulated and how metabolism can influence the signaling pathways leading to apoptosis, especially focusing on how glucose and lipid metabolism are altered in cancer cells and how these alterations can impact the apoptotic pathways.

Web of Science ® 被引用回数 : 83

リンク情報
DOI
https://doi.org/10.1016/bs.ircmb.2016.06.006
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27692180
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819894
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000394566900002&DestApp=WOS_CPL
URL
http://europepmc.org/abstract/med/27692180
URL
http://orcid.org/0000-0003-4612-6031
ID情報
  • DOI : 10.1016/bs.ircmb.2016.06.006
  • ISSN : 1937-6448
  • ORCIDのPut Code : 45669884
  • PubMed ID : 27692180
  • PubMed Central 記事ID : PMC5819894
  • Web of Science ID : WOS:000394566900002

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