論文

査読有り
2018年

Activation of disulfide bond cleavage triggered by hydrophobization and lipophilization of functionalized dihydroasparagusic acid

Organic and Biomolecular Chemistry
  • Fuyuhiko Inagaki
  • ,
  • Miyuki Momose
  • ,
  • Naoya Maruyama
  • ,
  • Kenkyo Matsuura
  • ,
  • Tsukasa Matsunaga
  • ,
  • Chisato Mukai

16
23
開始ページ
4320
終了ページ
4324
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1039/c8ob01055b
出版者・発行元
Royal Society of Chemistry

Concisely synthesized and functionalized dihydroasparagusic acid (DHAA) derivatives were used to show that the introduction of a hydrophobic functional group dramatically reduced air oxidation activity at the dithiol moieties and dominantly activated the cleavage of S-S bonds in proteins, presumably due to the hydrophobization and lipophilization. Notably, the reaction sites of water-reactive dithiol moieties behaved similarly to hydrophobic and lipophilic functional groups, which suggests impersonation of the reaction site.

リンク情報
DOI
https://doi.org/10.1039/c8ob01055b
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29808899
URL
http://europepmc.org/abstract/med/29808899
URL
http://orcid.org/0000-0003-4612-6031
ID情報
  • DOI : 10.1039/c8ob01055b
  • ISSN : 1477-0520
  • ORCIDのPut Code : 45674057
  • PubMed ID : 29808899
  • SCOPUS ID : 85048632282

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