論文

査読有り 国際誌
2020年4月

Higher Accumulation of Docosahexaenoic Acid in the Vermilion of the Human Lip than in the Skin

International Journal of Molecular Sciences
  • Md. Al Mamun
  • Shumpei Sato
  • Eiji Naru
  • Osamu Sakata
  • Emi Hoshikawa
  • Ayako Suzuki
  • Ariful Islam
  • Tomoaki Kahyo
  • Tomohito Sato
  • Takashi K. Ito
  • Makoto Horikawa
  • Reimu Fukui
  • Kenji Izumi
  • Mitsutoshi Setou
  • 全て表示

21
8
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3390/ijms21082807

The vermilion of the human lip is a unique facial area because of certain distinguishing features from the adjacent tissues such as the white lip (skin) and oral mucosa. However, the distinction in terms of molecular distribution between the vermilion and skin has remained unexplored. Therefore, we aimed to map the human lip by mass spectrometry imaging to gain understanding of the free fatty acid distribution in the vermilion. The lip specimens trimmed off during cheiloplasty were analyzed using desorption electrospray ionization-mass spectrometry imaging. Distributions of two monounsaturated fatty acids and three polyunsaturated fatty acids were observed in the human lip tissue: palmitoleic acid (POA) and oleic acid (OA) and linoleic acid (LA), arachidonic acid (AA), and docosahexaenoic acid (DHA), respectively. Although POA, OA, LA, and AA were differentially distributed across the vermilion and skin, DHA showed a higher accumulation in the epithelium of the vermilion compared to that in the skin. Our results clearly demonstrated the difference in fatty acid distributions between the vermilion and skin. The highly abundant DHA in the epithelium of the vermilion may have an antioxidant role and may thus protect the lip from aging. Our findings can provide a novel strategy for treating lip disorders.

リンク情報
DOI
https://doi.org/10.3390/ijms21082807
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32316553
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215545
URL
https://www.mdpi.com/1422-0067/21/8/2807
ID情報
  • DOI : 10.3390/ijms21082807
  • ORCIDのPut Code : 72556445
  • PubMed ID : 32316553
  • PubMed Central 記事ID : PMC7215545

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