今泉研人 (Kent Imaizumi) - マイポータル

基本情報

所属: Stanford University Postdoctoral Scholar

J-GLOBAL ID: 201801005133741518
researchmap会員ID: B000304099

研究分野

ライフサイエンス / 発生生物学 /

論文

Rescue of imprinted genes by epigenome editing in human cellular models of Prader-Willi syndrome

Akisa Nemoto, Kent Imaizumi, Fuyuki Miya, Yuka Hiroi, Mamiko Yamada, Hirosato Ideno, Shinji Saitoh, Kenjiro Kosaki, Hironobu Okuno, Hideyuki Okano

Nature Communications 2025年10月28日査読有り
Timing matters: Genetic regulation of neuronal maturation in the primate brain.

Kent Imaizumi, Sergiu P Paşca

Neuron 113(15) 2375-2377 2025年8月6日筆頭著者
Human assembloid model of the ascending neural sensory pathway

Ji-il Kim, Kent Imaizumi, Ovidiu Jurjuț, Kevin W. Kelley, Dong Wang, Mayuri Vijay Thete, Zuzana Hudacova, Neal D. Amin, Rebecca J. Levy, Grégory Scherrer …

Nature 2025年6月5日査読有り筆頭著者
Assembloid CRISPR screens reveal impact of disease genes in human neurodevelopment

Xiangling Meng, David Yao, Kent Imaizumi, Xiaoyu Chen, Kevin W. Kelley, Noah Reis, Mayuri Vijay Thete, Arpana Arjun McKinney, Shravanti Kulkarni, Georgia Panagiotakos …

Nature 2023年10月12日査読有り
Astrocytic APOE4 genotype-mediated negative impacts on synaptic architecture in human pluripotent stem cell model

Hirotaka Watanabe, Rei Murakami, Kazuya Tsumagari, Satoru Morimoto, Tadafumi Hashimoto, Kent Imaizumi, Iki Sonn, Kaoru Yamada, Yuko Saito, Shigeo Murayama …

Stem Cell Reports 2023年8月査読有り
Roadmap for developing biologically inspired therapeutics for genetic brain disorders

Kent Imaizumi, Sergiu P. Paşca

Trends in Molecular Medicine 2023年8月査読有り筆頭著者
Human PSCs determine the competency of cerebral organoid differentiation via FGF signaling and epigenetic mechanisms.

Hirosato Ideno, Kent Imaizumi, Hiroko Shimada, Tsukasa Sanosaka, Akisa Nemoto, Jun Kohyama, Hideyuki Okano

iScience 25(10) 105140-105140 2022年10月21日査読有り筆頭著者責任著者
A next-generation iPSC-derived forebrain organoid model of tauopathy with tau fibrils by AAV-mediated gene transfer.

Hiroko Shimada, Yuta Sato, Takashi Sasaki, Aki Shimozawa, Kent Imaizumi, Tomoko Shindo, Sachiyo Miyao, Kosuke Kiyama, Takahiro Kondo, Shinsuke Shibata …

Cell reports methods 2(9) 100289-100289 2022年9月19日査読有り
Gene therapy using genome‐edited iPS cells for targeting malignant glioma

Ryota Tamura, Hiroyuki Miyoshi, Kent Imaizumi, Masahiro Yo, Yoshitaka Kase, Tsukika Sato, Mizuto Sato, Yukina Morimoto, Oltea Sampetrean, Jun Kohyama …

Bioengineering & Translational Medicine 2022年9月10日査読有り
A non-invasive system to monitor in vivo neural graft activity after spinal cord injury

Kentaro Ago, Narihito Nagoshi, Kent Imaizumi, Takahiro Kitagawa, Momotaro Kawai, Keita Kajikawa, Reo Shibata, Yasuhiro Kamata, Kota Kojima, Munehisa Shinozaki …

Communications Biology 5(1) 2022年8月10日査読有り
Pathogenic Mutation of TDP-43 Impairs RNA Processing in a Cell Type-Specific Manner: Implications for the Pathogenesis of ALS/FTLD

Kent Imaizumi, Hirosato Ideno, Tsukika Sato, Satoru Morimoto, Hideyuki Okano

eneuro 2022年5月査読有り筆頭著者
Modulation by DREADD reveals the therapeutic effect of human iPSC-derived neuronal activity on functional recovery after spinal cord injury.

Takahiro Kitagawa, Narihito Nagoshi, Yasuhiro Kamata, Momotaro Kawai, Kentaro Ago, Keita Kajikawa, Reo Shibata, Yuta Sato, Kent Imaizumi, Tomoko Shindo …

Stem cell reports 17(1) 127-142 2022年1月11日査読有り
Long-term selective stimulation of transplanted neural stem/progenitor cells for spinal cord injury improves locomotor function

Momotaro Kawai, Kent Imaizumi, Mitsuru Ishikawa, Shinsuke Shibata, Munehisa Shinozaki, Takahiro Shibata, Shogo Hashimoto, Takahiro Kitagawa, Kentaro Ago, Keita Kajikawa …

Cell Reports 37(8) 110019-110019 2021年11月査読有り
Non-viral Induction of Transgene-free iPSCs from Somatic Fibroblasts of Multiple Mammalian Species.

Sho Yoshimatsu, Mayutaka Nakajima, Aozora Iguchi, Tsukasa Sanosaka, Tsukika Sato, Mari Nakamura, Ryusuke Nakajima, Eri Arai, Mitsuru Ishikawa, Kent Imaizumi …

Stem cell reports 16(4) 754-770 2021年3月23日査読有り
Flexible and accurate substrate processing with distinct presenilin/γ-secretases in human cortical neurons.

Hirotaka Watanabe, Kent Imaizumi, Tetsuo Cai, Zhi Zhou, Taisuke Tomita, Hideyuki Okano

eNeuro 2021年2月15日査読有り
Generation of region-specific and high-purity neurons from human feeder-free iPSCs.

Tsukika Sato, Kent Imaizumi, Hirotaka Watanabe, Mitsuru Ishikawa, Hideyuki Okano

Neuroscience letters 746 135676-135676 2021年1月28日査読有り
Human Astrocytes Model Derived from Induced Pluripotent Stem Cells.

Nicolas Leventoux, Satoru Morimoto, Kent Imaizumi, Yuta Sato, Shinichi Takahashi, Kyoko Mashima, Mitsuru Ishikawa, Iki Sonn, Takahiro Kondo, Hirotaka Watanabe …

Cells 9(12) 2020年12月13日査読有り
Modeling neurodevelopment in a dish with pluripotent stem cells.

Kent Imaizumi, Hideyuki Okano

Development, growth & differentiation 2020年11月3日査読有り筆頭著者
Cell therapy for spinal cord injury by using human iPSC-derived region-specific neural progenitor cells.

Keita Kajikawa, Kent Imaizumi, Munehisa Shinozaki, Shinsuke Shibata, Tomoko Shindo, Takahiro Kitagawa, Reo Shibata, Yasuhiro Kamata, Kota Kojima, Narihito Nagoshi …

Molecular brain 13(1) 120-120 2020年9月3日査読有り筆頭著者
A combinational treatment of carotenoids decreases Aβ secretion in human neurons via β-secretase inhibition.

Sho M, Ichiyanagi N, Imaizumi K, Ishikawa M, Morimoto S, Watanabe H, Okano H

Neuroscience research 158 47-55 2019年10月10日査読有り

もっとみる

共同研究・競争的資金等の研究課題

臓器形成における自発的対称性の破れをオルガノイドモデルで明らかにする

日本学術振興会科学研究費助成事業新学術領域研究(研究領域提案型) 2021年4月 - 2023年3月

今泉研人
領域特異的なiPS細胞由来神経幹細胞を用いた脊髄損傷に対する新しい再生医療の開発

日本学術振興会科学研究費助成事業若手研究 2019年4月 - 2021年3月

今泉研人