論文

査読有り
2014年10月

A Concise and Unified Strategy for Synthesis of the C1-C18 Macrolactone Fragments of FD-891, FD-892 and Their Analogues: Formal Total Synthesis of FD-891

ORGANIC LETTERS
  • Naoki Kanoh
  • ,
  • Ayano Kawamata
  • ,
  • Tomohiro Itagaki
  • ,
  • Yuta Miyazaki
  • ,
  • Kenzo Yahata
  • ,
  • Eunsang Kwon
  • ,
  • Yoshiharu Iwabuchi

16
19
開始ページ
5216
終了ページ
5219
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1021/ol502633j
出版者・発行元
AMER CHEMICAL SOC

A concise and unified strategy for the synthesis of C1-C18 macrolactone fragments of FD-891 and FD-892 as well as their analogues is reported. The strategy includes a stereoselective vinylogous Mukaiyama aldol reaction (VMAR) using chiral silyl ketene N,O-acetal to construct C6-C7 stereocenters, an E-selective ring closing metathesis to construct a C12-C13 olefin, and stereodivergent construction of a C8-C9 epoxide.

リンク情報
DOI
https://doi.org/10.1021/ol502633j
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000342719500063&DestApp=WOS_CPL
URL
http://www.scopus.com/inward/record.url?eid=2-s2.0-84907700856&partnerID=MN8TOARS
URL
http://orcid.org/0000-0002-6991-9221
ID情報
  • DOI : 10.1021/ol502633j
  • ISSN : 1523-7060
  • eISSN : 1523-7052
  • ORCIDのPut Code : 37567629
  • SCOPUS ID : 84907700856
  • Web of Science ID : WOS:000342719500063

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