2014年10月
A Concise and Unified Strategy for Synthesis of the C1-C18 Macrolactone Fragments of FD-891, FD-892 and Their Analogues: Formal Total Synthesis of FD-891
ORGANIC LETTERS
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- 巻
- 16
- 号
- 19
- 開始ページ
- 5216
- 終了ページ
- 5219
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1021/ol502633j
- 出版者・発行元
- AMER CHEMICAL SOC
A concise and unified strategy for the synthesis of C1-C18 macrolactone fragments of FD-891 and FD-892 as well as their analogues is reported. The strategy includes a stereoselective vinylogous Mukaiyama aldol reaction (VMAR) using chiral silyl ketene N,O-acetal to construct C6-C7 stereocenters, an E-selective ring closing metathesis to construct a C12-C13 olefin, and stereodivergent construction of a C8-C9 epoxide.
- リンク情報
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- DOI
- https://doi.org/10.1021/ol502633j
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000342719500063&DestApp=WOS_CPL
- URL
- http://www.scopus.com/inward/record.url?eid=2-s2.0-84907700856&partnerID=MN8TOARS
- URL
- http://orcid.org/0000-0002-6991-9221
- ID情報
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- DOI : 10.1021/ol502633j
- ISSN : 1523-7060
- eISSN : 1523-7052
- ORCIDのPut Code : 37567629
- SCOPUS ID : 84907700856
- Web of Science ID : WOS:000342719500063