論文

査読有り 国際誌
2018年5月

Regulation of NCAPG by miR-99a-3p (passenger strand) inhibits cancer cell aggressiveness and is involved in CRPC.

Cancer medicine
  • Takayuki Arai
  • ,
  • Atsushi Okato
  • ,
  • Yasutaka Yamada
  • ,
  • Sho Sugawara
  • ,
  • Akira Kurozumi
  • ,
  • Satoko Kojima
  • ,
  • Kazuto Yamazaki
  • ,
  • Yukio Naya
  • ,
  • Tomohiko Ichikawa
  • ,
  • Naohiko Seki

7
5
開始ページ
1988
終了ページ
2002
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1002/cam4.1455

Effective treatments for patients with castration-resistant prostate cancer (CRPC) have not yet been established. Novel approaches for identification of putative therapeutic targets for CRPC are needed. Analyses of RNA sequencing of microRNA (miRNA) expression revealed that miR-99a-3p (passenger strand) is significantly downregulated in several types of cancers. Here, we aimed to identify novel miR-99a-3p regulatory networks and therapeutic targets for CRPC. Ectopic expression of miR-99a-3p significantly inhibited cancer cell proliferation, migration, and invasion in PCa cells. Non-SMC condensin I complex subunit G (NCAPG) was a direct target of miR-99a-3p in PCa cells. Overexpression of NCAPG was detected in CRPC clinical specimens and was significantly associated with shorter disease-free survival and advanced clinical stage. Knockdown of NCAPG inhibited cancer cell aggressiveness. The passenger strand miR-99a-3p acted as an antitumor miRNA in naïve PCa and CRPC. NCAPG was regulated by miR-99a-3p, and its overexpression was involved in CRPC pathogenesis. Involvement of passenger strand of miRNA in cancer pathogenesis is novel concept, and identification of antitumor miRNA regulatory networks in CRPC might be provided novel prognostic markers and therapeutic targets for this disease.

リンク情報
DOI
https://doi.org/10.1002/cam4.1455
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29608247
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943442

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