Todo Kagefumi

Profile Information

Affiliation: Associate Professor, Faculty of Human Sciences Department of Health and Nutrition, Tokiwa University

J-GLOBAL ID: 201301016113366324
researchmap Member ID: B000228498

External link: http://kaken.nii.ac.jp/d/r/50452561.ja.html

Research Interests

Research Areas

Life sciences / Immunology /

Research History

Apr, 2022 - Present

Associate Professor, Faculty of Human Science, Tokiwa University
May, 2018 - Mar, 2022

Assistant Professor, School of Medicine, Shiga University of Medical Science
Jul, 2008 - Mar, 2017

Researcher, Graduate School of Medicine, Kyoto University
Apr, 2007 - Jun, 2008

Assistant Professor, Faculty of Engineering, Okayama University
Oct, 2006 - Mar, 2007

Research Fellow PD, Japan Society for the Promotion of Science
Apr, 2005 - Sep, 2006

Research Fellow DC2, Japan Society for the Promotion of Science

Papers

Characterization of tumour-infiltrating lymphocytes in a tumour rejection cynomolgus macaque model.

Hiroki Satooka, Hirohito Ishigaki, Kagefumi Todo, Koji Terada, Yasutoshi Agata, Yasushi Itoh, Kazumasa Ogasawara, Takako Hirata

Scientific reports, 10(1) 8414-8414, May 21, 2020 Peer-reviewed
Oligomers imaging of amyloid-β (1-42) by scanning tunneling microscopy

Nobuyasu Naruse, Hiroki Satooka, Kagefumi Todo, Akio Nakanishi, Hiroyasu Taguchi, Yutaka Mera

JAPANESE JOURNAL OF APPLIED PHYSICS, 58(SI) SIIB30-SIIB30, Aug, 2019 Peer-reviewed
Modulation of Igβ is essential for the B cell selection in germinal center.

Kagefumi Todo, Orie Koga, Miwako Nishikawa, Masaki Hikida

Scientific reports, 5 10303-10303, May 18, 2015 Peer-reviewed
IgG1 cytoplasmic tail is essential for cell surface expression in Igβ down-regulated cells.

Kagefumi Todo, Orie Koga, Miwako Nishikawa, Masaki Hikida

Biochemical and biophysical research communications, 445(3) 572-7, Mar 14, 2014 Peer-reviewed
Activation-induced cytidine deaminase (AID)-dependent somatic hypermutation requires a splice isoform of the serine/arginine-rich (SR) protein SRSF1.

Yuichi Kanehiro, Kagefumi Todo, Misaki Negishi, Junji Fukuoka, Wenjian Gan, Takuya Hikasa, Yoshiaki Kaga, Masayuki Takemoto, Masaki Magari, Xialu Li, James L Manley, Hitoshi Ohmori, Naoki Kanayama

Proceedings of the National Academy of Sciences of the United States of America, 109(4) 1216-21, Jan 24, 2012 Peer-reviewed
Efficient affinity maturation of antibodies in an engineered chicken B cell line DT40-SW by increasing point mutation.

Masamichi Kajita, Takahiro Okazawa, Mika Ikeda, Kagefumi Todo, Masaki Magari, Naoki Kanayama, Hitoshi Ohmori

Journal of bioscience and bioengineering, 110(3) 351-8, Sep, 2010 Peer-reviewed
Enhancement of hypermutation frequency in the chicken B cell line DT40 for efficient diversification of the antibody repertoire.

Masaki Magari, Yuichi Kanehiro, Kagefumi Todo, Mika Ikeda, Naoki Kanayama, Hitoshi Ohmori

Biochemical and biophysical research communications, 396(2) 353-8, May 28, 2010 Peer-reviewed
Conditional transformation of immunoglobulin mutation pattern from gene conversion into point mutation by controlling XRCC3 expression in the DT40 B cell line.

Masamichi Kajita, Masaki Magari, Kagefumi Todo, Naoki Kanayama, Hitoshi Ohmori

Journal of bioscience and bioengineering, 109(4) 407-10, Apr, 2010 Peer-reviewed
Enhancement of antibody production from a chicken B cell line DT40 by reducing Pax5 expression.

Masaki Magari, Takahiro Aya, Mika Ikeda, Kagefumi Todo, Naoki Kanayama, Hitoshi Ohmori

Journal of bioscience and bioengineering, 107(2) 206-9, Feb, 2009 Peer-reviewed
Loss of calcineurin homologous protein-1 in chicken B lymphoma DT40 cells destabilizes Na+/H+ exchanger isoform-1 protein.

Masafumi Matsushita, Yoshie Sano, Shunsuke Yokoyama, Tomoyo Takai, Hiroki Inoue, Keiji Mitsui, Kagefumi Todo, Hitoshi Ohmori, Hiroshi Kanazawa

American journal of physiology. Cell physiology, 293(1) C246-54-C254, Jul, 2007 Peer-reviewed
Novel in vitro screening system for monoclonal antibodies using hypermutating chicken B cell library.

Kagefumi Todo, Kenji Miyake, Masaki Magari, Naoki Kanayama, Hitoshi Ohmori

Journal of bioscience and bioengineering, 102(5) 478-81, Nov, 2006 Peer-reviewed
Genetic manipulation of an exogenous non-immunoglobulin protein by gene conversion machinery in a chicken B cell line.

Naoki Kanayama, Kagefumi Todo, Satoko Takahashi, Masaki Magari, Hitoshi Ohmori

Nucleic acids research, 34(2) e10-9, Jan 18, 2006 Peer-reviewed
Reversible switching of immunoglobulin hypermutation machinery in a chicken B cell line.

Naoki Kanayama, Kagefumi Todo, Michael Reth, Hitoshi Ohmori

Biochemical and biophysical research communications, 327(1) 70-5, Feb 4, 2005 Peer-reviewed
B cell selection and affinity maturation during an antibody response in the mouse with limited B cell diversity.

Naoki Kanayama, Takafumi Kimoto, Kagefumi Todo, Yumiko Nishikawa, Masaki Hikida, Masaki Magari, Marilia Cascalho, Hitoshi Ohmori

Journal of immunology (Baltimore, Md. : 1950), 169(12) 6865-74, Dec 15, 2002 Peer-reviewed

Misc.

Redox-mediated SOCS3 expression in regulatory T cells is involved in the development of autoimmunity

SATOOKA Hiroki, NAKAMURA Yuzuki, TODO Kagefumi, HIRATA Takako

日本免疫学会総会・学術集会記録(CD-ROM), 50, 2021
Augmentation of auto-antibody production in Parm1-deficient NZB mice.

FUKUSHIMA Sayaka, ISHIKAWA Mizuki, TODO Kagefumi, HONDA Haruka, HIKIDA Masaki

日本免疫学会総会・学術集会記録(CD-ROM), 50, 2021
Production of secreted form of IgD during immune responses

TODO Kagefumi, SATOOKA Hiroki, HIRATA Takako

日本免疫学会総会・学術集会記録(CD-ROM), 50, 2021
TおよびB細胞のナルディライジンによる抗体産生調節機構の解明

茶谷元晴, 藤井貴之, 藤堂景史, 大野美紀子, 西清人, 平田多佳子, 安藤朗, 西英一郎

日本病態プロテアーゼ学会学術集会プログラム抄録集, 26th, 2021
Regulation of B cell development, activation, and function Roles of IgA cytoplasmic tail on cell surface expression

Sugawara Kei, Todo Kagefumi, Hikida Masaki

日本免疫学会総会・学術集会記録, 48(Proceedings) 2-P, Nov, 2019
Regulation of B cell development, activation, and function Phagocytic cells are induced by activation of resting splenic B cells

Asano Kyoko, Todo Kagefumi, Hirata Takako

日本免疫学会総会・学術集会記録, 48(Proceedings) 2-P, Nov, 2019
Rheumatoid arthritis, Sjogren's syndrome and other autoimmune diseases Redox-mediated signaling in regulatory T cells is involved in the development of autoimmunity

Satooka Hiroki, Sato Tomomi, Nakamura Yuzuki, Todo Kagefumi, Hirata Takako

日本免疫学会総会・学術集会記録, 48(Proceedings) 3-P, Nov, 2019
Involvement of IgD-expressing cells in type I hypersensitivity

Todo Kagefumi, Asano Kyoko, Satooka Hiroki, Hirata Takako

日本免疫学会総会・学術集会記録, 48(Proceedings) 3-P, Nov, 2019
Roles of IgA cytoplasmic tail on cell surface expression

SUGAWARA Kei, TODO Kagefumi, HIKIDA Masaki

日本免疫学会総会・学術集会記録(CD-ROM), 48, 2019
Regulatory mechanism for intracellular sorting of Parm1 by phosphorylation of NPxY motif)

Ishikawa Mizuki, Todo Kagefumi, Hikida Masaki

日本免疫学会総会・学術集会記録, 47(Proceedings) 1-P, Dec, 2018
Analysis of intracellular localization of Parm1 in B cells

Sugiyama Honami, Todo Kagefumi, Hikida Masaki

日本免疫学会総会・学術集会記録, 47(Proceedings) 1-P, Dec, 2018
誘電泳動を利用した癌細胞の分離

清水淳, 西村友美, 柴沼洋子, 藤堂景史, 脇坂嘉一, 戸井雅和

日本乳癌学会総会プログラム抄録集, 26回 632-632, May, 2018
Regulatory mechanism for intracellular sorting of Parm1 by NPxY motif

Ishikawa Mizuki, Todo Kagefumi, Hikida Masaki

日本免疫学会総会・学術集会記録, 46(Proceedings) 3-P, Dec, 2017
胚中心によるB細胞選択機構と記憶B細胞の生成

疋田正喜, 藤堂景史

酵素工学ニュ-ス, (77), 2017
Endogenous retrovirus-induced B lymphomagenesis and immune surveillance in mice

Todo Kagefumi, Hikida Masaki

日本免疫学会総会・学術集会記録, 45(Proceedings) 92-92, Nov, 2016
免疫記憶 IgG発現B細胞におけるParm1発現の調節機構(Immunological memory Regulatory mechanism of Parm1 expression in IgG-expressing B cells)

Hikida Masaki, Todo Kagefumi

日本免疫学会総会・学術集会記録, 45(Proceedings) 186-186, Nov, 2016
免疫応答におけるメモリーB細胞の調節(Regulation of memory B cells in immune responses)

Hikida Masaki, Todo Kagefumi, Tanaka Nobuo

日本免疫学会総会・学術集会記録, 44(Proceedings) 219-219, Oct, 2015
Bリンパ球シグナル伝達 T依存性免疫応答におけるParm1の生理学的役割(B lymphocyte signaling Physiological roles of Parm1 in T-dependent immune responses)

Todo Kagefumi, Hikida Masaki

日本免疫学会総会・学術集会記録, 44(Proceedings) 180-180, Oct, 2015
B細胞内のシグナル伝達機構(第4回) 胚中心B細胞のシグナル伝達機構

藤堂景史, 疋田正喜

炎症と免疫, 23(6) 535-540, Oct, 2015
A novel negative regulator in class-switched B cells

藤堂景史, 疋田正喜

臨床免疫・アレルギー科, 63(6) 532-537, Jun, 2015

Research Projects

I型アレルギーでのアレルゲン特異的IgE生成におけるIgD抗体産生細胞の役割

科学研究費助成事業基盤研究(C), 日本学術振興会, Apr, 2020 - Mar, 2023

藤堂景史
内在性レトロウイルス依存的Bリンパ腫発生機構とその免疫監視機構の解析

科学研究費助成事業基盤研究(C), 日本学術振興会, Apr, 2016 - Mar, 2019

藤堂景史
Analysis of the role of CD3 molecule expressing in germinal center B cells

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

Todo Kagefumi
胚中心でのIgβ発現量に依存する新規なB細胞選択経路の解析

科学研究費助成事業特定領域研究, 日本学術振興会, 2010 - 2011

疋田正喜, 藤堂景史
Analysis of the role of cytoplasmictail in IgG molecule for the development and the sustention of memory B cells

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2009 - 2010

TODO Kagefumi
B細胞の変異能力を応用するタンパク分子進化システムの構築

科学研究費助成事業特別研究員奨励費, 日本学術振興会, 2005 - 2006

藤堂景史

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