Kazuyuki Fujimitsu

The C-terminal disordered loop domain of Apc8 unlocks APC/C mitotic activation

Sarah Darling, Kazuyuki Fujimitsu, Kim Hou Chia, Juan Zou, Juri Rappsilber, Hiroyuki Yamano

Cell Reports, 43(6) 114262-114262, Jun, 2024 Peer-reviewed

CDK1-PP2A-B55 interplay ensures cell cycle oscillation via Apc1-loop300

Kim Hou Chia, Hiroko Takaki, Kazuyuki Fujimitsu, Sarah Darling, Juan Zou, Juri Rappsilber, Hiroyuki Yamano

Cell Reports, 43(5) 114155-114155, May, 2024 Peer-reviewed

Dynamic regulation of mitotic ubiquitin ligase APC/C by coordinated Plx1 kinase and PP2A phosphatase action on a flexible Apc1 loop.

Kazuyuki Fujimitsu, Hiroyuki Yamano

The EMBO journal, 40(18) e107516, Sep 15, 2021 Peer-reviewedLead author

PP2A-B56 binds to Apc1 and promotes Cdc20 association with the APC/C ubiquitin ligase in mitosis.

Kazuyuki Fujimitsu, Hiroyuki Yamano

EMBO reports, 21(1) e48503, Jan 7, 2020 Peer-reviewedLead author

Chromosomal location of the DnaA-reactivating sequence DARS2 is important to regulate timely initiation of DNA replication in Escherichia coli.

Yukie Inoue, Hiroyuki Tanaka, Kazutoshi Kasho, Kazuyuki Fujimitsu, Taku Oshima, Tsutomu Katayama

Genes to cells : devoted to molecular & cellular mechanisms, 21(9) 1015-23, Sep, 2016 Peer-reviewed

Targeting of Fzr/Cdh1 for timely activation of the APC/C at the centrosome during mitotic exit.

Francesco Meghini, Torcato Martins, Xavier Tait, Kazuyuki Fujimitsu, Hiroyuki Yamano, David M Glover, Yuu Kimata

Nature communications, 7 12607-12607, Aug 25, 2016 Peer-reviewed

Cyclin-dependent kinase 1-dependent activation of APC/C ubiquitin ligase.

Kazuyuki Fujimitsu, Margaret Grimaldi, Hiroyuki Yamano

Science (New York, N.Y.), 352(6289) 1121-4, May 27, 2016 Peer-reviewedLead author

Timely binding of IHF and Fis to DARS2 regulates ATP-DnaA production and replication initiation.

Kazutoshi Kasho, Kazuyuki Fujimitsu, Toshihiro Matoba, Taku Oshima, Tsutomu Katayama

Nucleic acids research, 42(21) 13134-49, Dec 1, 2014 Peer-reviewedLead author

A synthetic lethal interaction between APC/C and topoisomerase poisons uncovered by proteomic screens.

Manuel Eguren, Mónica Álvarez-Fernández, Fernando García, Andrés J López-Contreras, Kazuyuki Fujimitsu, Hiroko Yaguchi, José Luis Luque-García, Oscar Fernández-Capetillo, Javier Muñoz, Hiroyuki Yamano …

Cell reports, 6(4) 670-83, Feb 27, 2014 Peer-reviewed

Anaphase-promoting complex/cyclosome-mediated proteolysis of Ams2 in the G1 phase ensures the coupling of histone gene expression to DNA replication in fission yeast.

Michelle Trickey, Kazuyuki Fujimitsu, Hiroyuki Yamano

The Journal of biological chemistry, 288(2) 928-37, Jan 11, 2013 Peer-reviewed

Dephosphorylation of Cdc20 is required for its C-box-dependent activation of the APC/C.

Helene Labit, Kazuyuki Fujimitsu, N Sumru Bayin, Tohru Takaki, Julian Gannon, Hiroyuki Yamano

The EMBO journal, 31(15) 3351-62, Aug 1, 2012 Peer-reviewed

Suppressors of DnaA(ATP) imposed overinitiation in Escherichia coli.

Godefroid Charbon, Leise Riber, Malene Cohen, Ole Skovgaard, Kazuyuki Fujimitsu, Tsutomu Katayama, Anders Løbner-Olesen

Molecular microbiology, 79(4) 914-28, Feb, 2011 Peer-reviewed

Regulation of the replication cycle: conserved and diverse regulatory systems for DnaA and oriC.

Tsutomu Katayama, Shogo Ozaki, Kenji Keyamura, Kazuyuki Fujimitsu

Nature reviews. Microbiology, 8(3) 163-70, Mar, 2010 Peer-reviewed

Specific genomic sequences of E. coli promote replicational initiation by directly reactivating ADP-DnaA.

Kazuyuki Fujimitsu, Takayuki Senriuchi, Tsutomu Katayama

Genes & development, 23(10) 1221-33, May 15, 2009 Peer-reviewedLead author

Loss of Hda activity stimulates replication initiation from I-box, but not R4 mutant origins in Escherichia coli.

Leise Riber, Kazuyuki Fujimitsu, Tsutomu Katayama, Anders Løbner-Olesen

Molecular microbiology, 71(1) 107-22, Jan, 2009 Peer-reviewed

Modes of overinitiation, dnaA gene expression, and inhibition of cell division in a novel cold-sensitive hda mutant of Escherichia coli.

Kazuyuki Fujimitsu, Masayuki Su'etsugu, Yoko Yamaguchi, Kensaku Mazda, Nisi Fu, Hironori Kawakami, Tsutomu Katayama

Journal of bacteriology, 190(15) 5368-81, Aug, 2008 Peer-reviewedLead author

The interaction of DiaA and DnaA regulates the replication cycle in E. coli by directly promoting ATP DnaA-specific initiation complexes.

Kenji Keyamura, Norie Fujikawa, Takuma Ishida, Shogo Ozaki, Masayuki Su'etsugu, Kazuyuki Fujimitsu, Wataru Kagawa, Shigeyuki Yokoyama, Hitoshi Kurumizaka, Tsutomu Katayama

Genes & development, 21(16) 2083-99, Aug 15, 2007 Peer-reviewed

The exceptionally tight affinity of DnaA for ATP/ADP requires a unique aspartic acid residue in the AAA+ sensor 1 motif.

Hironori Kawakami, Shogo Ozaki, Shigeo Suzuki, Kenta Nakamura, Takayuki Senriuchi, Masayuki Su'etsugu, Kazuyuki Fujimitsu, Tsutomu Katayama

Molecular microbiology, 62(5) 1310-24, Dec, 2006 Peer-reviewed

The DnaA homolog of the hyperthermophilic eubacterium Thermotoga maritima forms an open complex with a minimal 149-bp origin region in an ATP-dependent manner.

Shogo Ozaki, Kazuyuki Fujimitsu, Hitoshi Kurumizaka, Tsutomu Katayama

Genes to cells : devoted to molecular & cellular mechanisms, 11(4) 425-38, Apr, 2006 Peer-reviewed

Reconstitution of in vitro inactivation and reactivation systems of DnaA protein for the control of chromosomal replication initiation in Escherichia coli

Masayuki Su'etsugu, Kazuyuki Fujimitsu, Tsutomu Katayama

2006 IEEE INTERNATIONAL SYMPOSIUM ON MICRO-NANOMECHATRONICS AND HUMAN SCIENCE, 334-+, 2006

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