KYOKO HIDAKA

Profile Information

Affiliation: Center for Fundamental Education, The University of Kitakyushu

Degree: 理学博士(九州大学)

Researcher number: 00216681
J-GLOBAL ID: 201801009634868025
researchmap Member ID: B000313271

External link: http://www.kitakyu-u.ac.jp

Research Areas

Life sciences / Genomics /

Papers

DNA polymerase delta Exo domain stabilizes mononucleotide microsatellites in human cells.

Seijiro Shioi, Akiyoshi Shimamoto, Yingxia Song, Kyoko Hidaka, Maki Nakamura, Ayumi Take, Namiko Hayashi, Soichi Takiguchi, Ryosuke Fujikane, Masumi Hidaka …

DNA repair, 108 103216-103216, Dec, 2021 Peer-reviewed
DNAポリメラーゼδExoドメイン変異によって不安定化される1塩基繰返しマイクロサテライト

織田信弥, 塩井誠次郎, 瀧口総一, 日高京子, 藤兼亮輔, 日高真純, 中津可道

日本癌学会総会記事, 80回 [P6-7], Sep, 2021
Decreased YAP activity reduces proliferative ability in human induced pluripotent stem cell of duchenne muscular dystrophy derived cardiomyocytes

Hideki Yasutake, Jong-Kook Lee, Akihito Hashimoto, Kiyoshi Masuyama, Jun Li, Yuki Kuramoto, Shuichiro Higo, Shungo Hikoso, Kyoko Hidaka, Atsuhiko T. Naito …

SCIENTIFIC REPORTS, 11(1), May, 2021 Peer-reviewed
CRISPR/Cas9を用いてDNAポリメラーゼδR506H変異を導入したMSH2欠損HeLa細胞におけるゲノム不安定性(Genomic instability in MSH2-null HeLa cells with DNA polymerase delta R506H mutation introduced by CRISPR/Cas9)

織田信弥, 日高京子, 林田元気, 藤兼亮輔, 日高真純, 續輝久, 中津可道

日本癌学会総会記事, 78回 E-3078, Sep, 2019
Differential genomic destabilisation in human cells with pathogenic MSH2 mutations introduced by genome editing.

Hayashida G, Shioi S, Hidaka K, Fujikane R, Hidaka M, Tsurimoto T, Tsuzuki T, Oda S, Nakatsu Y

Experimental cell research, 377(1-2) 24-35, Apr, 2019 Peer-reviewed
Geometrical Patterning and Constituent Cell Heterogeneity Facilitate Electrical Conduction Disturbances in a Human Induced Pluripotent Stem Cell-Based Platform: An In vitro Disease Model of Atrial Arrhythmias.

Nakanishi H, Lee JK, Miwa K, Masuyama K, Yasutake H, Li J, Tomoyama S, Honda Y, Deguchi J, Tsujimoto S …

Frontiers in physiology, 10 818-818, 2019 Peer-reviewed
CRISPR/Cas9システムを用いてリンチ症候群MSH2変異を導入したヒト細胞におけるゲノム不安定性の特異な態様(Paradoxical genomic destabilisation in human cells with Lynch syndrome MSH2 mutations introduced by CRISPR/Cas9 system)

織田信弥, 林田元気, 日高京子, 藤兼亮輔, 日高真純, 續輝久, 中津可道

日本癌学会総会記事, 77回 1557-1557, Sep, 2018
Somatic mutation analysis of oxidative stress-induced colon cancer model

Ohno Mizuki, Takano Noriko, Kyoko Hidaka, Sakumi Kunihiko, Nakabeppu Yusaku, Nakatsu Yoshimichi, Tsuzuki Teruhisa

CANCER SCIENCE, 109 136-136, Jan, 2018 Peer-reviewed
Oxidative stress-induced mutagenesis in Msh2-deficient mice

Takano Noriko, Ohno Mizuki, Hidaka Kyoko, Nakatsu Yoshimichi, Tsuzuki Teruhisa

CANCER SCIENCE, 109 578-578, Jan, 2018 Peer-reviewed
リンチ症候群患者に見出された変異型MSH2を持つヒト細胞株の樹立とその解析

林田元気, 中津可道, 日高京子, 藤兼亮輔, 日高真純, 織田信弥, 釣本敏樹, 續輝久

生命科学系学会合同年次大会, 2017年度 [2P-1097], Dec, 2017
リンチ症候群患者に見出されるMSH2 ATPaseドメイン変異体は、ヒト細胞において顕著な不安定性を示す

林田元気, 中津可道, 日高京子, 藤兼亮輔, 日高真純, 織田信弥, 續輝久

日本癌学会総会記事, 76回 J-1025, Sep, 2017
Vestigial-like 2 contributes to normal muscle fiber type distribution in mice

Masahiko Honda, Kyoko Hidaka, So-ichiro Fukada, Ryo Sugawa, Manabu Shirai, Masahito Ikawa, Takayuki Morisaki

SCIENTIFIC REPORTS, 7(1) 7168, Aug, 2017 Peer-reviewed
Cited4 is related to cardiogenic induction and maintenance of proliferation capacity of embryonic stem cell-derived cardiomyocytes during in vitro cardiogenesis

Junichiro Miake, Tomomi Notsu, Katsumi Higaki, Kyoko Hidaka, Takayuki Morisaki, Kazuhiro Yamamoto, Ichiro Hisatome

PLOS ONE, 12(8) e0183225, Aug, 2017 Peer-reviewed
ヒト細胞を用いたミスマッチ修復因子MSH2の変異体の解析

林田元気, 中津可道, 日高京子, 藤兼亮輔, 日高真純, 續輝久

日本癌学会総会記事, 75回 P-3114, Oct, 2016
リンチ症候群で発見されたミスマッチ修復因子MSH2変異体の特性分析(Characterization of mismatch repair factor MSH2 variants found in Lynch syndrome)

林田元気, 中津可道, 日高京子, 藤兼亮輔, 日高真純, 釣本敏樹, 續輝久

日本放射線影響学会大会講演要旨集, 59回 7-7, Oct, 2016
Electrophysiological Properties of Prion-Positive Cardiac Progenitors Derived From Murine Embryonic Stem Cells

Hiroshi Fujii, Yu Ikeuchi, Yasutaka Kurata, Nobuhito Ikeda, Udin Bahrudin, Peili Li, Yuji Nakayama, Ryo Endo, Akira Hasegawa, Kumi Morikawa …

CIRCULATION JOURNAL, 76(12) 2875-2883, Dec, 2012 Peer-reviewed
Differentiation of Pharyngeal Endoderm from Mouse Embryonic Stem Cell

Kyoko Hidaka, Takeshi Nitta, Ryo Sugawa, Manabu Shirai, Robert J. Schwartz, Takashi Amagai, Sachiko Nitta, Yousuke Takahama, Takayuki Morisaki

STEM CELLS AND DEVELOPMENT, 19(11) 1735-1743, Nov, 2010 Peer-reviewed
RNA-binding motif protein 24 regulates myogenin expression and promotes myogenic differentiation

Donghao Jin, Kyoko Hidaka, Manabu Shirai, Takayuki Morisaki

GENES TO CELLS, 15(11) 1158-1167, Nov, 2010 Peer-reviewed
Different distribution of Cav3.2 and Cav3.1 transcripts encoding T-type Ca2+ channels in the embryonic heart of mice

Einosuke Mizuta, Manabu Shirai, Keita Arakawa, Kyoko Hidaka, Junichiro Miake, Haruaki Ninomiya, Masahiko Kato, Chiaki Shigemasa, Yasuaki Shirayoshi, Ichiro Hisatome …

BIOMEDICAL RESEARCH-TOKYO, 31(5) 301-305, Oct, 2010 Peer-reviewed
The Cellular Prion Protein Identifies Bipotential Cardiomyogenic Progenitors

Kyoko Hidaka, Manabu Shirai, Jong-Kook Lee, Takanari Wakayama, Itsuo Kodama, Michael D. Schneider, Takayuki Morisaki

CIRCULATION RESEARCH, 106(1) 111-U230, Jan, 2010 Peer-reviewed

Misc.

DNAポリメラーゼδExoドメイン変異によって不安定化される1塩基繰返しマイクロサテライト

織田信弥, 塩井誠次郎, 瀧口総一, 日高京子, 藤兼亮輔, 日高真純, 中津可道

日本癌学会学術総会抄録集(Web), 80th, 2021
全学共通初年次必修科目「アカデミック・スキルズⅠ」への取り組み

浅羽修丈, 伊野憲治, 伊原木大祐, 漆原朗子, 神原ゆうこ, 小林道彦, 戸蒔仁司, 中尾泰士, 永末康介, 日高京子 …

第68回九州地区大学教育研究協議会, 17-17, Sep 21, 2019
全学共通初年次必修科目「アカデミック・スキルズⅠ」への取り組み

浅羽修丈, 伊野憲治, 伊原木大祐, 漆原朗子, 神原ゆうこ, 小林道彦, 戸蒔仁司, 中尾泰士, 永末康介, 日高京子 …

68 53-59, Sep 20, 2019
慢性的な機械的過負荷に対する骨格筋の適応におけるVgll2の機能解析

本多賢彦, 日高京子, 土持裕胤, 森崎隆幸

生命科学系学会合同年次大会, 2017年度 [2P-0494], Dec, 2017
環境発がん研究とゲノム解析の統合大規模ゲノムデータから発がん要因を紐解く(環境-ゲノムネットワーク) 大腸癌モデルマウスを用いた酸化ストレス誘発発がんと体細胞突然変異の解析

大野みずき, 鷹野典子, 日高京子, 作見邦彦, 中別府雄作, 中津可道, 續輝久

日本癌学会総会記事, 76回 S2-3, Sep, 2017
Msh2欠損マウスを用いた酸化ストレス誘発体細胞突然変異の解析

鷹野典子, 大野みずき, 日高京子, 中津可道, 續輝久

日本癌学会総会記事, 76回 P-2012, Sep, 2017
Isolation of mismatch repair factor MSH2 variants found in Lynch syndrome with CRISPR/Cas9 system

Genki Hayashida, Yoshimichi Nakatsu, Kyoko Hidaka, Ryosuke Fujikane, Masumi Hidaka, Toshiki Tsurimoto, Teruhisa Tsuzuki

GENES & GENETIC SYSTEMS, 91(6) 368-368, Dec, 2016
P-067 Analysis of de novo germline mutations in Msh2 deficient mice(Poster Sessions)

Ohno Mizuki, Takano Noriko, Sasaki Fumiko, Hidaka Kyoko, Nakatsu Yoshimichi, Tsuzuki Teruhisa

日本環境変異原学会大会プログラム・要旨集, (44) 126-126, 2015
P-037 Development a differentiation system using pluripotent stem cells to screen genotoxic substances for heart development(Poster Sessions)

Hidaka Kyoko, Nakatsu Yoshimichi, Hidaka Masumi, Tsuzuki Teruhisa

日本環境変異原学会大会プログラム・要旨集, (44) 111-111, 2015
P-020 Oxidative stress-induced mutagenesis and tumorigenesis in Mutyh-deficient mice(Poster Sessions)

Takano Noriko, Ohno Mizuki, Sasaki Fumiko, Nakabeppu Yusaku, Hidaka Kyoko, Nakatsu Yoshimichi, Tsuzuki Teruhisa

日本環境変異原学会大会プログラム・要旨集, (44) 102-102, 2015
P-100 Analysis of oxidative stress-induced intestinal tumors in Trp53-deficient mice(Poster Sessions)

Li Zan, Ohno Mizuki, Takano Noriko, Sasaki Fumiko, Hidaka Kyoko, Nakatsu Yoshimichi, Tsuzuki Teruhisa

日本環境変異原学会大会プログラム・要旨集, (44) 142-142, 2015
An Attempt of Science Communication for Parents and Their Children

中尾泰士, 日高京子, 佐々木実

基盤教育センター紀要, (11) 75-101, Dec, 2011
PJ-272 Cyclin-dependent kinases-9 is required for the differentiation of mouse ES cells into cardiac myocytes.(Development and differentiation(02)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

Kaichi Shinji, Takaya Tomohide, Sunagawa Yoichi, Kawamura Teruhisa, Ono Kou, Morimoto Tatsuya, Kita Toru, Baba shiro, Hidaka Kyoko, Morisaki Takayuki …

Circulation journal : official journal of the Japanese Circulation Society, 72 579-580, Mar 1, 2008
Activation of MEK-ERK by heregulin-beta 1 promotes the development of cardiomyocytes derived from ES cells (vol 361, pg 732, 2007)

Hoe Suk Kim, Jin Won Cho, Kyoko Hidaka, Takayuki Morisaki

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 365(4) 889-889, Jan, 2008
Perspective on ES cells and cardiac regeneration

森崎隆幸, 日高京子

Respiration and circulation, 55(7) 715-720, Jul, 2007
PJ-760 Cyclin-Dependent Kinases-9, as a Novel Component of p300/GATA-4 Complex, is Involved in Differentiation of Mouse ES Cells into Cardiac Myocytes(Development and differentiation-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

Kaichi Shinji, Takaya Tomohide, Morimoto Tatsuya, Sunagawa Yoichi, Kawamura Teruhisa, Ono Kou, Kita Toru, Hidaka Kyoko, Morisaki Takayuki, Baba Shiro …

Circulation journal : official journal of the Japanese Circulation Society, 71 662-662, Mar 1, 2007
PE-298 Feasibility of Undifferentiated ES Cell Engraftment to Diseased Hearts is Limited by Tumorigenesis and Apoptosis through Leukemia Inhibitory Factor (LIF)(Regeneration (angionenesis/myocardial regeneration)-5 (M) PE50,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)

Ando Monami, Lee Jong-kook, Hidaka Kyoko, Miwa Keiko, Hayano Satoshi, Kasai Kenji, Morisaki Takayuki, Kodama Itsuo

Circulation journal : official journal of the Japanese Circulation Society, 70 408-408, Mar 1, 2006
PE-103 The Role of cAMP/PKA Pathway in the Differentiation of Embryonic Stem Cells into Cardiac Myocytes(Development and differentiation-2 (M) PE18,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)

Takaya Tomohide, Kawamura Teruhisa, Ono Kou, Hidaka Kyoko, Morisaki Takayuki, Heike Toshio, Nakahata Tatsutoshi, Kita Toru, Hasegawa Koji

Circulation journal : official journal of the Japanese Circulation Society, 70 360-361, Mar 1, 2006
Biological repair of chronic complete atrio-ventricular block by transplantation of embryonic stem cell-derived cardiac myocytes

JK Lee, K Hidaka, D Yuasa, M Kado, K Miwa, M Horiba, T Morisaki, Kodama, I

CIRCULATION, 112(17) U277-U277, Oct, 2005
再生医療カニクイザルES細胞を用いた心筋再生療法

長谷川浩二, 川村晃久, 尾野亘, Hosseinkhani Mohsen, 古川裕, 日高京子, 森崎隆幸, 平家俊男, 中畑龍俊, 末盛博文 …

日本臨床分子医学会学術総会プログラム・抄録集, 42回 49-49, Jul, 2005

Research Projects

心臓アンチエイジング薬の開発を目指したヒトiPS細胞由来老化心筋モデルの構築

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2026

日高京子, 大野みずき
卵子が持つ精子DNA損傷を修復する能力の分子機構の解明

科学研究費助成事業基盤研究(B), 基盤研究(B), 日本学術振興会, Apr, 2020 - Mar, 2024

大野みずき, 手島康介, 日高京子, 作見邦彦, 續輝久, 中津可道
Analysis of genome maintenance mechanism in pluripotent stem cells: toward highly sensitive mutation detection methods

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2019

HIDAKA KYOKO, NAKATSU yoshimichi, HIDAKA masumi, HAYASHIDA genki, OHNO mizuki
Development of differentiated cardiac conduction cell from pulipotent stem cell

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2015

SUTO Fumiaki, HIDAKA Kyouko
Transcriptome analysis of cardiac progenitors to identify small RNAs that induce transdifferentiation

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2011 - 2013

HIDAKA KYOKO, NAKAZAWA Koji, SAKURAI Kazuo
Functional study on muscle nucleotide metabolism and AMP-activated protein kinase

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2006 - 2007

MORISAKI Takayuki, MORISAKI Hiroko, HIDAKA Kyoko, CHENG Jidong
Regeneration of sinus node〜 reconstitution of biological pacemaker using bio-nanotechnololgy

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2006 - 2007

LEE Jong-kook, HIDAKA Kyoko, ITO Akira, KODAMA Itsuo
Isolation and analysis of transcription factors associated with Nkx2-5 and cardiac differentiation

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2005 - 2006

HIDEKA Kyoko, MORISAKI Takayuki, SHIRAI Manabu
Study of New Roles in AMP Metabolism by Using Gene Modified Animals

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2004 - 2005

MORISAKI Takayuki, MORISAKI Hiroko, HIDAKA Kyoko
A new therapeutic approach to bradyarrhythmias using regenerated myocardium 〜 development of biological pacemaker

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2004 - 2005

LEE Jong-Kook, HIDAKA Kyoko, MORISAKI Takayuki, KODAMA Itsuo
ローカスワイドSNPハプロタイプ解析による代謝異常症候群疾患感受性遺伝子の探索

科学研究費助成事業特定領域研究, 特定領域研究, 日本学術振興会, 2004 - 2004

森崎隆幸, 森崎裕子, 日高京子
Development of a System to Isolate Cardiac Progenitor Cells Derived from Embryonic Stem Cells

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2003 - 2004

HIDAKA Kyoko, MORISAKI Takayuki
Regeneration of myocardium using bone marrow cells for the treatment of severe heart failure

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2002 - 2004

SUGA Michiharu, NAKATANI Takeshi, HIDAKA Kyoko
A novel approach to treat arrhythmias using embryonic stem-derived cardiac pacemaker cells

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2002 - 2003

LEE Jong-kook, MORISAKI Takayuki, HIDAKA Kyoko, KODAMA Itsuo
Collection and Analysis of Genetic Polymorphism Relating to Energy Metabolism

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2002 - 2003

MORISAKI Takayuki, HIDAKA Kyoko, MORISAKI Hiroko
共培養システムによる骨髄細胞等の心筋分化誘導に関する研究

科学研究費助成事業萌芽研究, 萌芽研究, 日本学術振興会, 2002 - 2003

菅理晴, 富田伸司, 由谷親夫, 中谷武嗣, 菅理晴, 日高京子
平滑筋細胞の分化におけるMEF2関連因子・新規転写因子の単離と解析

科学研究費助成事業特定領域研究(A), 特定領域研究(A), 日本学術振興会, 1998 - 1998

森崎隆幸, 日高京子
Functional analysis of AMPD gene family in cellular and animal models

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 1997 - 1998

MORISAKI Takayuki, MORISAKI Hiroko, HIDAKA Kyoko
平滑筋細胞の分化におけるMEF2遺伝子群の役割の解析

科学研究費助成事業重点領域研究, 重点領域研究, 日本学術振興会, 1997 - 1997

森崎隆幸, 向井常博, 日高京子
二つのプロモーターの比較による心筋と骨格筋の転写活性化機構の違いについての解析

科学研究費助成事業奨励研究(A), 奨励研究(A), 日本学術振興会, 1994 - 1994

日高京子

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