Hiroko Kitamoto

Profile Information

Affiliation: Osaka University

Degree: 博士（医学(Sep, 2012, 鹿児島大学)

Researcher number: 90911991
ORCID ID: https://orcid.org/0000-0001-6952-242X
J-GLOBAL ID: 202101015451805453
researchmap Member ID: R000020084

Research Interests

Research Areas

Research History

Apr, 2022 - Present

大阪大学世界最先端研究機構免疫学フロンティア研究センター (IFReC) 免疫微生物学
Jul, 2019 - Feb, 2022

ミシガン大学医学部消化器内科 Reserach Fellow (CCF Career Development Award)
Apr, 2019 - Feb, 2022

ミシガン大学医学部消化器内科 Reserach Investigator
Jan, 2016 - Dec, 2018

ミシガン大学医学部消化器内科 Reserach Fellow (CCF Research Fellowship Award)
Apr, 2014 - Dec, 2015

ミシガン大学医学部消化器内科 Reserach Fellow (日本学術振興会海外特別研究員)
Apr, 2013 - Mar, 2014

Hokkaido University
Oct, 2012 - Mar, 2013

Hokkaido University
Sep, 2009 - Oct, 2012

鹿児島大学大学院医歯学総合研究科整形外科学 (日本学術振興会特別研究員DC)

Education

Oct, 2009 - Sep, 2012

国立大学鹿児島大学大学院医歯学総合研究科 (整形外科学)

Awards

Nov, 2023

大阪大学賞
Apr, 2021

United Japanese researchers Around the world, Paper Award
Jul, 2019

CCF Career Development Award
Jul, 2017

第34回リバネス研究費メタジェン・腸内デザイン賞奨励賞
Jul, 2017

The Kenneth Rainin Foundation, Travel Award
Feb, 2016

The 21st Annual Environmental Health Sciences Research Symposium, Best Poster Award
Jan, 2016

CCF Research Fellowship Award
Apr, 2014

Astellas Foundation Research Fellowship
Apr, 2014

JSPS Fellowship for Postdoctoral Fellowship
Aug, 2012

鹿児島大学大学院医歯学奨励賞
Apr, 2012

JSPS Research Fellowship
Jan, 2012

第5 回桜ヶ丘地区基礎系研究発表会優秀発表賞
Jul, 2011

第29 回日本骨代謝学会学術集会優秀ポスター賞

Papers

Adherent-invasive E. coli - induced specific IgA limits pathobiont localization to the epithelial niche in the gut.

Rika Tanaka, Jin Imai, Hitoshi Tsugawa, Karl Bil Eap, Masaki Yazawa, Motoki Kaneko, Masashi Ohno, Kohei Sugihara, Sho Kitamoto, Hiroko Nagao-Kitamoto …

Frontiers in microbiology, 14 1031997-1031997, 2023 Peer-reviewed
Mucolytic bacteria license pathobionts to acquire host-derived nutrients during dietary nutrient restriction.

Kohei Sugihara, Sho Kitamoto, Prakaimuk Saraithong, Hiroko Nagao-Kitamoto, Matthew Hoostal, Caroline McCarthy, Alexandra Rosevelt, Chithra K Muraleedharan, Merritt G Gillilland 3rd, Jin Imai …

Cell reports, 40(3) 111093-111093, Jul 19, 2022 Peer-reviewed
Inflammatory bowel disease and carcinogenesis

Hiroko Nagao-Kitamoto, Sho Kitamoto, Nobuhiko Kamada

Cancer and Metastasis Reviews, Apr 13, 2022 Peer-reviewedLead authorCorresponding author
A potential pathogenic association between periodontal disease and Crohn’s disease

Jin Imai, Hitoshi Ichikawa, Sho Kitamoto, Jonathan L. Golob, Motoki Kaneko, Junko Nagata, Miho Takahashi, Merritt G. Gillilland, Rika Tanaka, Hiroko Nagao-Kitamoto …

JCI Insight, 6(23), Dec 8, 2021 Peer-reviewed
The Butyrate-Producing Bacterium Clostridium butyricum Suppresses Clostridioides difficile Infection via Neutrophil- and Antimicrobial Cytokine-Dependent but GPR43/109a-Independent Mechanisms.

Atsushi Hayashi, Hiroko Nagao-Kitamoto, Sho Kitamoto, Chang H Kim, Nobuhiko Kamada

Journal of immunology (Baltimore, Md. : 1950), 206(7) 1576-1585, Apr 1, 2021 Peer-reviewed
DUOX2 variants associate with preclinical disturbances in microbiota-immune homeostasis and increased inflammatory bowel disease risk.

Helmut Grasberger, Andrew T Magis, Elisa Sheng, Matthew P Conomos, Min Zhang, Lea S Garzotto, Guoqing Hou, Shrinivas Bishu, Hiroko Nagao-Kitamoto, Mohamad El-Zataari …

The Journal of clinical investigation, 131(9), Mar 2, 2021 Peer-reviewed
The Bacterial Connection between the Oral Cavity and the Gut Diseases

S. Kitamoto, H. Nagao-Kitamoto, R. Hein, T.M. Schmidt, N. Kamada

Journal of Dental Research, 99(9) 1021-1029, Aug, 2020 Peer-reviewed
The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis.

Sho Kitamoto, Hiroko Nagao-Kitamoto, Yizu Jiao, Merritt G Gillilland 3rd, Atsushi Hayashi, Jin Imai, Kohei Sugihara, Mao Miyoshi, Jennifer C Brazil, Peter Kuffa …

Cell, 182(2) 447-462, Jul 23, 2020 Peer-reviewed
Interleukin-22-mediated host glycosylation prevents Clostridioides difficile infection by modulating the metabolic activity of the gut microbiota.

Hiroko Nagao-Kitamoto, Jhansi L Leslie, Sho Kitamoto, Chunsheng Jin, Kristina A Thomsson, Merritt G Gillilland 3rd, Peter Kuffa, Yoshiyuki Goto, Robert R Jenq, Chiharu Ishii …

Nature medicine, 26(4) 608-617, Apr, 2020 Peer-reviewedLead author
Dietary L-serine confers a competitive fitness advantage to Enterobacteriaceae in the inflamed gut.

Sho Kitamoto, Christopher J Alteri, Michael Rodrigues, Hiroko Nagao-Kitamoto, Kohei Sugihara, Stephanie D Himpsl, Malak Bazzi, Mao Miyoshi, Tatsuki Nishioka, Atsushi Hayashi …

Nature microbiology, 5(1) 116-125, Jan, 2020 Peer-reviewed
Development of Immortalized Human Tumor Endothelial Cells from Renal Cancer.

Nako Maishi, Hiroshi Kikuchi, Masumi Sato, Hiroko Nagao-Kitamoto, Dorcas A Annan, Shogo Baba, Takayuki Hojo, Misa Yanagiya, Yusuke Ohba, Genichiro Ishii …

International journal of molecular sciences, 20(18), Sep 17, 2019 Peer-reviewed
Flagellin-mediated activation of IL-33-ST2 signaling by a pathobiont promotes intestinal fibrosis.

Jin Imai, Sho Kitamoto, Kohei Sugihara, Hiroko Nagao-Kitamoto, Atsushi Hayashi, Tina L Morhardt, Peter Kuffa, Peter D R Higgins, Nicolas Barnich, Nobuhiko Kamada

Mucosal immunology, 12(3) 632-643, May, 2019 Peer-reviewed
IL-10 produced by macrophages regulates epithelial integrity in the small intestine.

Tina L Morhardt, Atsushi Hayashi, Takanori Ochi, Miguel Quirós, Sho Kitamoto, Hiroko Nagao-Kitamoto, Peter Kuffa, Koji Atarashi, Kenya Honda, John Y Kao …

Scientific reports, 9(1) 1223-1223, Feb 4, 2019 Peer-reviewed
Quantitative proteomics identifies STEAP4 as a critical regulator of mitochondrial dysfunction linking inflammation and colon cancer.

Xiang Xue, Bryce X Bredell, Erik R Anderson, Angelical Martin, Christopher Mays, Hiroko Nagao-Kitamoto, Sha Huang, Balázs Győrffy, Joel K Greenson, Karin Hardiman …

Proceedings of the National Academy of Sciences of the United States of America, 114(45) E9608-E9617, Nov 7, 2017 Peer-reviewed
Host-microbial Cross-talk in Inflammatory Bowel Disease.

Hiroko Nagao-Kitamoto, Nobuhiko Kamada

Immune network, 17(1) 1-12, Feb, 2017 Peer-reviewedLead author
Functional Characterization of Inflammatory Bowel Disease-Associated Gut Dysbiosis in Gnotobiotic Mice.

Hiroko Nagao-Kitamoto, Andrew B Shreiner, Merritt G Gillilland 3rd, Sho Kitamoto, Chiharu Ishii, Akiyoshi Hirayama, Peter Kuffa, Mohamad El-Zaatari, Helmut Grasberger, Anna M Seekatz …

Cellular and molecular gastroenterology and hepatology, 2(4) 468-481, Jul, 2016 Peer-reviewedLead author
Diet-dependent, microbiota-independent regulation of IL-10-producing lamina propria macrophages in the small intestine.

Takanori Ochi, Yongjia Feng, Sho Kitamoto, Hiroko Nagao-Kitamoto, Peter Kuffa, Koji Atarashi, Kenya Honda, Daniel H Teitelbaum, Nobuhiko Kamada

Scientific reports, 6 27634-27634, Jun 15, 2016 Peer-reviewed
Tumour endothelial cells in high metastatic tumours promote metastasis via epigenetic dysregulation of biglycan.

Nako Maishi, Yusuke Ohba, Kosuke Akiyama, Noritaka Ohga, Jun-Ichi Hamada, Hiroko Nagao-Kitamoto, Mohammad Towfik Alam, Kazuyuki Yamamoto, Taisuke Kawamoto, Nobuo Inoue …

Scientific reports, 6 28039-28039, Jun 13, 2016 Peer-reviewed
Pathogenic role of the gut microbiota in gastrointestinal diseases.

Hiroko Nagao-Kitamoto, Sho Kitamoto, Peter Kuffa, Nobuhiko Kamada

Intestinal research, 14(2) 127-38, Apr, 2016 Peer-reviewedLead author
Regulation of virulence: the rise and fall of gastrointestinal pathogens.

Sho Kitamoto, Hiroko Nagao-Kitamoto, Peter Kuffa, Nobuhiko Kamada

Journal of gastroenterology, 51(3) 195-205, Mar, 2016 Peer-reviewed

Books and Other Publications

腸管における液性免疫による感染制御

臨床免疫・アレルギー科, 第64巻第6号 (科学評論社), Dec, 2015
NLRC4インフラマソームと消化管免疫

G.I.Research (先端医学社), Oct, 2015
骨肉腫におけるHedgehog関連因子の強発現と細胞周期制御

ORTHO TIMES, 05(03), 2011

Professional Memberships

Apr, 2018

日本免疫学会 (JSI)

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Research Areas

Research History

Education

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