論文

査読有り
2013年

Clinicopathological and Molecular Histochemical Review of Skull Base Metastasis from Differentiated Thyroid Carcinoma

ACTA HISTOCHEMICA ET CYTOCHEMICA
  • Akira Matsuno
  • ,
  • Mineko Murakami
  • ,
  • Katsumi Hoya
  • ,
  • Shoko M. Yamada
  • ,
  • Shinya Miyamoto
  • ,
  • So Yamada
  • ,
  • Jae-Hyun Son
  • ,
  • Hajime Nishido
  • ,
  • Fuyuaki Ide
  • ,
  • Hiroshi Nagashima
  • ,
  • Mutsumi Sugaya
  • ,
  • Toshio Hirohata
  • ,
  • Akiko Mizutani
  • ,
  • Hiroko Okinaga
  • ,
  • Yudo Ishii
  • ,
  • Shigeyuki Tahara
  • ,
  • Akira Teramoto
  • ,
  • R. Yoshiyuki Osamura
  • ,
  • Kazuto Yamazaki
  • ,
  • Yasuo Ishida

46
5
開始ページ
129
終了ページ
136
記述言語
英語
掲載種別
DOI
10.1267/ahc.13019
出版者・発行元
JAPAN SOC HISTOCHEMISTRY & CYTOCHEMISTRY

Skull base metastasis from differentiated thyroid carcinoma including follicular thyroid carcinoma (FTC) and papillary thyroid carcinoma (PTC) is a rare clinical entity. Eighteen FTC cases and 10 PTC cases showing skull base metastasis have been reported. The most common symptom of skull base metastasis from FTC and PTC is cranial nerve dysfunction. Bone destruction and local invasion to the surrounding soft tissues are common on radiological imaging. Skull base metastases can be the initial clinical presentation of FTC and PTC in the presence of silent primary sites. The possibility of skull base metastasis from FTC and PTC should be considered in patients with the clinical symptoms of cranial nerve dysfunction and radiological findings of bone destruction. A variety of genetic alterations in thyroid tumors have been identified to have a fundamental role in their tumorigenesis. Molecular histochemical studies are useful for elucidating the histopathological features of thyroid carcinoma. Recent molecular findings may provide novel molecular-based treatment strategies for thyroid carcinoma.

Web of Science ® 被引用回数 : 10

リンク情報
DOI
https://doi.org/10.1267/ahc.13019
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/24194626
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000326586900001&DestApp=WOS_CPL

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