論文

査読有り
2013年3月

Urinary growth hormone level and insulin-like growth factor-1 standard deviation score (IGF-SDS) can discriminate adult patients with severe growth hormone deficiency

ENDOCRINE JOURNAL
  • Toshio Hirohata
  • ,
  • Nobuhito Saito
  • ,
  • Koji Takano
  • ,
  • So Yamada
  • ,
  • Jae-Hyun Son
  • ,
  • Shoko M. Yamada
  • ,
  • Hiroshi Nakaguchi
  • ,
  • Katsumi Hoya
  • ,
  • Mineko Murakami
  • ,
  • Akiko Mizutani
  • ,
  • Hiroko Okinaga
  • ,
  • Akira Matsuno

60
3
開始ページ
369
終了ページ
373
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1507/endocrj.EJ12-0196
出版者・発行元
JAPAN ENDOCRINE SOC

Adult growth hormone (GH) deficiency (AGHD) in Japan is diagnosed based on peak GH concentrations during GH provocative tests such as GHRP-2 stimulation test. In this study, we aimed to evaluate the ability of serum insulin-like growth factor-1 (sIGF-1) and urinary GH (uGH) at the time of awakening to diagnose AGHD. Fifty-nine patients with pituitary disease (32 men and 27 women; age 20-85 y (57.5 +/- 15.5, mean +/- SD) underwent GHRP-2 stimulation and sIGF-1 testing. Thirty-six and 23 patients were diagnosed with and without severe AGHD, respectively based on a peak GH response of <9 ng/mL to GHRP-2 stimulation. Serum IGF-1 was evaluated as a standard deviation score (IGF-1 SDS) based on age and sex. We determined whether uGH levels in urine samples from 42 of the 59 patients at awakening were above or below the sensitivity limit. We evaluated IGF-1 SDS and uGH levels in a control group of 15 healthy volunteers. Values for IGF-1 SDS were significantly lower in patients with, than without (-2.07 +/- 1.77 vs.-0.03 +/- 0.92, mean SD; p <0.001) AGHD whereas the range of IGF-1 SDS substantially overlapped at >-1.4. IGF-1 SDS discriminated AGHD more effectively inpatients aged <= 60 years. They chi(2) test revealed a statistical relationship between uGH and AGHD (test statistic: 7.0104 >= chi(2) (1; 0.01) = 6.6349). When IGF-1 SDS is <-1.4 or uGH is below the sensitivity limit, AGHD can be detected with high sensitivity.

Web of Science ® 被引用回数 : 1

リンク情報
DOI
https://doi.org/10.1507/endocrj.EJ12-0196
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/23197045
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000319091600014&DestApp=WOS_CPL

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