Hirayama Jun

J-GLOBAL         Last updated: Oct 7, 2019 at 11:16
 
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Name
Hirayama Jun
E-mail
jun.hirayamakomatsu-u.ac.jp
Affiliation
KOMATSU UNIVERSITY
Section
Department of Clinical Engineering, Faculty of Health Sciences
Job title
Professor
Degree
Ph.D(Kyoto University)
Research funding number
90510363

Research Interests

 
 

Research Areas

 
 

Academic & Professional Experience

 
Apr 2018
 - 
Today
Professor, Department of Clinical Engineering, Faculty of Health Sciences, Komatsu University
 
Oct 2010
 - 
Mar 2018
Medical Research Institute, Tokyo Medical and Dental University
 
Mar 2008
 - 
Oct 2010
Medical Research Institute, Tokyo Medical and Dental University
 
Apr 2006
 - 
Feb 2008
Postdoctoral Fellow, University of California Irvine
 
Apr 2003
 - 
Mar 2006
Postdoctoral Fellow, Paolo Sassone-corsi lab., Institute of Genetics and Molecular and Cellular Biology
 

Education

 
Apr 2000
 - 
Mar 2003
Graduate School of Human and Environmental Studies, Kyoto University
 
Apr 1998
 - 
Mar 2000
Graduate School of Human and Environmental Studies, Kyoto University
 
Apr 1994
 - 
Mar 1998
School of Allied Health Sciences, Osaka University
 

Published Papers

 
The use of chemical compounds to identify the regulatory mechanisms of vertebrate circadian clocks
Hirayama Jun
Curr. Drug Targets   Epub ahead of print   2019   [Refereed]
Melatonin is a potential drug for the prevention of bone loss during space flight.
Ikegame M, Hattori A, Tabata MJ, Kitamura K, Tabuchi Y, Furusawa Y, Maruyama Y, Yamamoto T, Sekiguchi T, Matsuoka R, Hanmoto T, Ikari T, Endo M, Omori K, Nakano M, Yashima S, Ejiri S, Taya T, Nakashima H, Shimizu N, Nakamura M, Kondo T, Hayakawa K, Takasaki I, Kaminishi A, Akatsuka R, Sasayama Y, Nishiuchi T, Nara M, Iseki H, Chowdhury SV, Wada S, Ijiri K, Takeuchi T, Suzuki T, Ando H, Matsuda K, Somei M, Mishima H, Mikuni-Takagaki Y, Funahashi H, Takahashi A, Watanebe Y,  Maeda M, Uchida H, Hayashi A, Kambegawa A, Seki A, Yano A, Shimazu T, Suzuki H, Hirayama J, Suzuki N.
J. Pineal Res.   67(e12594)    2019   [Refereed]
The zebrafish as an attractive model animal for the study of the circadian clocks.
Hirayama J# (#Corresponding author)
Circadian clock: Regulations, Genetic and External Factors (Edited by Nathaniel Hayes) Nova Science Publishers   103-127   2018   [Refereed]
Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK7
Yamasaki T, Deki-Arima N, Kaneko A, Miyamura N, Iwatsuki M, Matsuoka M, Fujimori-Tonou N, Okamoto-Uchida Y, Hirayama J, Marth J, Yamanashi Y, Kawasaki H, Yamanaka K, Penninger J, Shibata S, and Nishina H
Sci. Rep.   7 7348   2017   [Refereed]
Screening with a fluorescence reporter-based assay for YAP1 activators identifies a novel compound that suppresses multiple myeloma proliferation.
Maruyama J, Inami K, Michishita F, Jiang X, Iwasa H, Nakagawa K, Ishigami-Yuasa M, Kagechika H, Miyamura N, Hirayama J, Nishina H, Nogawa D, Yamamoto K, and Hata Y
Mol. Cancer Res.   16 197-211   2018   [Refereed]
Manganese and cobalt activate zebrafish ovarian cancer G-protein coupled receptor 1 but not GPR4
Negishi J, Omori Y, Shindo M, Takanashi H, Musha S, Nagayama S, Hirayama J, Nishina H, Nakakura T, Mogi C, Sato K, Okajima F, Mochimaru Y, Tomura H
J Recept Signal Transduct Res   137 401-408   2017   [Refereed]
Shimomura T, Miyamura N, Hata S, Miura R, Hirayama J#, Nishina H# (#Corresponding authors)
Biochem. Biophys. Res. Commun.   376 206-210   2014   [Refereed]
Egg M, Köblitz L, Hirayama J, Schwerte T Folterbauer C, Kurz A, Fiechtner B, Möst M, Salvenmoser W, Sassone- Corsi P, Pelster B.
Chronobiol. Int.   30 510-529   2013   [Refereed]
Hata S, Hirayama J, Kajiho H, Nakagawa K, Hata Y, Katada T, Furutani-Seiki M, Nishina H
J. Biol. Chem..   287 22089-22098   Jun 2012   [Refereed]
Uchida Y, Osaki T, Yamasaki T, Shimomura T, Hata S, Horikawa K, Shibata S, Todo T, Hirayama J#, NishinaH. (#Corresponding author)
J. Biol. Chem.   287 8318-8326   2012   [Refereed]
Osaki T, Uchida Y, Hirayama J#, Nishina H (#Corresponding author)
Biol. Pharm. Bull.   34 1343-1347   2011   [Refereed]
Uchida Y, Shimomura T, Hirayama J#, NishinaH (#Corresponding author)
Appl. Magn. Reson.   42 69-77   2011   [Refereed]
Uchida Y, Hirayama J#, Nishina H. (#Corresponding author)
Biol. Pharm. Bull.   33 535-544   2010   [Refereed]
Nakagawa K, Sugahara M, Yamasaki T, Kajiho H, Takahashi S, Hirayama J, Minami Y, Ohta Y, Watanabe T Hata Y, Katada T, Nishina H.
Biochem. J.   427 237-245   2010   [Refereed]
Seo J, Asaoka Y, Nagai Y, Hirayama J, Yamasaki T, Namae M, Ohata S, Shimizu N, Negishi T, Kitagawa D, Kondoh H, Furutani-Seiki M, Penninger JM, Katada T, Nishina H.
J. Cell. Biochem.   110 1022-1037   2010   [Refereed]
Wu J*, Kubota J*, Hirayama J*, Nagai Y, Nishina S, Yokoi T, Asaoka Y, Seo J, Shimizu N, Kajiho H, WatanabeT, Azuma N, Katada T, Nishina H. (* Contributed equally)
Stem. Cells Dev.   19 1723-1734   2010   [Refereed]
Grimaldi B, Bellet MM, Katada S, Astarita G, Hirayama J, Amin RH, Granneman JG, Piomelli D, Leff T,Sassone-Corsi P.
Cell Metab.   12 509-520   2010   [Refereed]
Hirayama J and Sassone-Corsi P.
The New Encyclopedia of Neuroscience. (Edited by Larry Squire et al.),  Elsevier Ltd.   1071-1080   2009   [Refereed]
Tamaru T, Hirayama J, Isojima Y, Nagai K, Norioka S, Takamatsu K, Sassone-Corsi P.
Nat. Struct. Mol. Biol.   16 446-448   2009   [Refereed]
Miyamura N*,Hirayama J*#, Sawanobori K, Tamaru T, Asaoka Y, Honda R, Yamamoto T, Uno H, Takamatsu K, Nishina H. (#Corresponding author, *Contributed equally)
Biol. Pharm. Bull.   32 1183-1189   2009   [Refereed]
Common light signaling pathways controlling DNA repair and circadian clock entrainment in zebrafish
Hirayama J#, Miyamura N, Uchida Y, Asaoka Y, Honda R, Sawanobori K, Todo T, Yamamoto T, Sassone-Corsi P#, Nishina H. (#Corresponding authors)
Cell Cycle.   8 2794-2801   2009   [Refereed]
Nakahata Y, Kaluzova M, Grimaldi B, Sahar S, Hirayama J, Chen D, Guarente LP, Sassone-Corsi P.
Cell   134 329-340   2008   [Refereed]
Acimovic J, Fink M, Pompon D, Bjorkhem I, Hirayama J, Sassone-Corsi P, Golicnik M, Rozman D.
Biochem. Biophys. Res. Commun.   376 206-210   2008   [Refereed]
Nakahata Y, Grimaldi B, Sahar S, Hirayama J, Sassone -Corsi P.
Curr. Opin. Cell. Bio.   19 230-237   2007   [Refereed]
Grimaldi B, Nakahata Y, Sahar S, Koluzova M, Gauthier D, Pham K, Patel N, Hirayama J, Sassone-Corsi, P.
Cold Spring Harbor Symp. Quant. Biol.   72 105-112   2007   [Refereed]
Hirayama J, Cho S, Sassone-Corsi P.
Proc. Natl. Acad. Sci. U. S. A.   104 15747-15752   2007   [Refereed]
Hirayama J, Sahar S, Grimaldi B, Tamaru T, Takamatsu K, Nakahata Y, Sassone-Corsi P.
Nature   405 1086-1090   2007   [Refereed]
Hirayama J*, Yujnovsky I*, Doi M, Borrelli E Sassone-Corsi P. (* Contributed equally)
Proc. Natl. Acad. Sci. U. S. A. Vol   103 6386-6391   2006   [Refereed]
Doi M, Hirayama J, Sassone-Corsi P.
Cell   25 497-508   2006   [Refereed]
Doi M, Yujnovsky I, Hirayama J, Malerba M, Tirotta E, Sassone-Corsi P, Borrelli E.
Nat. Neurosci.   9 732-734   2006   [Refereed]
Doi M, Cho S, Yujnovsky I, Hirayama J, Cermakian N, Cato A, Sassone-Corsi P.
J. Biol. Rhythms.   22 127-139   2006   [Refereed]
Differential functions of the Aurora-B and Aurora-C kinases in mammalian spermatogenesis.
Kimmins S, Crosio C, Kotaja N, Hirayama J, Monaco L, Ho¨o¨g C, van Duin M, Gossen JA, Sassone-Corsi P.
Mol. Endocrinol.   22 127-140   2006   [Refereed]
Hirayama J, Sassone-Corsi P.
Curr. Opin. Genet. Dev.   15 548-556   2005   [Refereed]
Hirayama J, Kaneko M, Cardone L, Cahill G, Sassone-Corsi P.
Methods Enzymol.   393 186-204   2005   [Refereed]
Cardone L, Hirayama J, Giordano F, Tamaru T, Palvimo J, Sassone-Corsi P.
Science   309 1390-1394   2005   [Refereed]
Hirayama J, Fukuda I, Ishikawa T, Kobayashi Y, Todo T.
Nucleic. Acids Res.   31 935-943   2003   [Refereed]
Hirayama J, Nakamura H, Ishikawa T, Kobayashi Y, Todo T.
J. Biol. Chem.   278 35620-35628   2003   [Refereed]
Hirayama J, Cardone L, Doi M, Sassone-Corsi P.
Proc. Natl. Acad. Sci. U. S. A. Vol.   102 10194-10199   2005   [Refereed]
Ikenaga M, Hirayama J, Kato T, Kitao H, Han ZB, Ishizaki K Nishizawa K, Suzuki F, Cannon TF, Fukui K, Shimazu T, Kamigaichi S, Ishioka N Matsumiya H.
J. Radiat. Res.   43 141-148   2002   [Refereed]
Ishikawa T, Hirayama J, Kobayashi Y, Todo T.
Genes Cells   7 1073-1086   2002   [Refereed]
Genetic changes induced in human cells in Space Shuttle experiment (STS-95).
Ishizaki K, Nishizawa K, Kato T, Kitao H, Han ZB, Hirayama J, Suzuki F, Cannon TF, Kamigaichi S, Tawarayama Y, Masukawa M, Shimazu T Ikenaga M.
Aviat. Space Environ. Med.   72 794-798   2001   [Refereed]
Genetic effects of space radiation and microgravity on cultured human tumor cells.
Ikenaga M, Ishizaki K Nishizawa K, Han ZB, Kitao H, Hirayama J, Kato T.
Exploring Future Research Strategies in Space Radiation Sciences. (Edited by Majima H. J. and FujitakaK.),IRYOKAGAKUSHA Co. Ltd.,   86-91   2000   [Refereed]
Kobayashi Y, Ishikawa T, Hirayama J, Daiyasu H, Kanai S, Toh H Fukuda I, Tsujimura T, Terada N, Kamei Y, Yuba S, Iwai S, Todo T.
Genes Cells   5 725-738   2000   [Refereed]
A molecular link between the circadian clock, DNA damage responses, and oncogene activation
Izawa J and Hirayama J# (#Corresponding author)
Oncogene (Edited by Pinar Erkekoǧlu) InTechOpen   1-15   2019   [Refereed]
Roles of MAPKs in circadian clock regulation in vertebrates.
Izawa J and Hirayama J# (#Corresponding author)
Mitogen-Activated Protein Kinases (MAPKs): Activation, Functions and Regulation (Edited by Charles K. Hester) Nova Science Publishers   29-54   2019   [Refereed]
The clock components Period2, Cryptochrome1a, and Cryptochrome2a function in establishing light-dependent behavioral rhythms and/or total activity levels in zebrafish
Hirayama J#, Alifu Y, Hamabe R, Yamaguchi S, Tomita J, Maruyama Y, Asaoka Y, Nakahama K, Tamaru T, Takamatsu K, Takamatsu N, Hattori A, Nishina S, Azuma N, Kawahara A, Kume K, Nishina H. (#Corresponding author)
Sci. Rep.   9 196   2019   [Refereed]
Light-dependent regulation of circadian clocks in vertebrates
Izawa J, Nishimura A, and Hirayama J# (#Corresponding author)
Chronobiology (Edited by Pavol Svorc) InTechOpen.   1-15   2019   [Refereed]

Conference Activities & Talks

 
Circadian rhythm establishment and sleep control by the light-induced clock factors [Invited]
Hirayama Jun
The 41st Annual Meeting of the Japan Neuroscience Society (Kobe, Japan)   Jul 2018   
Molecular mechanism of light-dependent establishment of circadian rhythm [Invited]
Hirayama Jun
8th Asia and Oceania Conference for Photobiology (Seoul, The Republic of Korea )   Nov 2017   
Molecular mechanism for the light-dependent establishment of circadian clock during development in zebrafish [Invited]
Hirayama Jun
7th Asia and Oceania Conference for Photobiology (Taipei, Taiwan)   Nov 2015   
Molecular mechanism for the light-dependent establishment of circadian clock during zebrafish development [Invited]
Hirayama Jun
Seminar in National Health Research Institutes (Zhunan, Taiwan)   Nov 2015   
Light-dependent transcription of circadian clock [Invited]
Hirayama Jun
Developmental Biology Seminar in University of Bath (Bath, UK)   Nov 2011   
Identification of novel kinase phosphorylating CRYPTOCHROME 1 to regulate its protein stability [Invited]
Hirayama Jun
5th Asia and Oceania Conference for Photobiology (Nara, Japan)   Jun 2011   
Light-dependent regulation of zebrafish circadian transcription [Invited]
Hirayama Jun
Spin Chemistry Meeting 2011 (Noordwijk, Netherlands)   May 2011   
Light-dependent transcriptional regulation of zebrafish Cryptochrome [Invited]
Hirayama Jun
15th International Congress on Photobiology (Dusseldorf, Germany)   Jun 2009   
Circadian control by the CLOCK histone acetyltransferase activity [Invited]
Hirayama Jun
Feb 2008   

Misc

 
Shedding light on zebrafish daily rhythms: Clock gene functions revealed.
Hirayama J and Nishina H
EurekAlert.      Feb 2019   [Refereed]
Effect of hypergravity on X-ray-induced cell cycle arrest in mouse m5S cells
Kitao H, Hirayama J, Kato T, Ikenaga M.
Biol Sci Space.   14(3) 222-223   Oct 2000   [Refereed]
STS-95 space experiment: analysis of mutations induced in human tumor cells
Ikenaga M, Ishizaki K, Nishizawa K, Suzuki F, Kato T, Kitao H, Han ZB, Hirayama J, Shimazu T, Kamigaichi S.
Biol Sci Space   13(3) 236-237   Sep 1999   [Refereed]

Awards & Honors

 
Nov 2017
AOSP Award for Young Scientists, Asia and Oceania Society for Photobiology
 
Sep 2016
TMDU Award for Young Researcher, Tokyo Medical and Dental University