2017年5月
Potency of whole virus particle and split virion vaccines using dissolving microneedle against challenges of H1N1 and H5N1 influenza viruses in mice
VACCINE
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- 巻
- 35
- 号
- 21
- 開始ページ
- 2855
- 終了ページ
- 2861
- 記述言語
- 英語
- 掲載種別
- 研究論文（学術雑誌）
- DOI
- 10.1016/j.vaccine.2017.04.009
- 出版者・発行元
- ELSEVIER SCI LTD
Transdermal vaccination using a microneedle (MN) confers enhanced immunity compared with subcutaneous (SC) vaccination. Here we developed a novel dissolving MN patch for the influenza vaccine. The potencies of split virion and whole virus particle (WVP) vaccines prepared from A/Puerto Rico/8/1934 (H1N1) and A/duck/Hokkaido/Vac-3/2007 (H5N1), respectively, were evaluated. MN vaccination induced higher neutralizing antibody responses than SC vaccination in mice. Moreover, MN vaccination with a lower dose of antigens conferred protective immunity against lethal challenges of influenza viruses than SC vaccination in mice. These results suggest that the WVP vaccines administered using MN are an effective combination for influenza vaccine to be further validated in humans. (C) 2017 Elsevier Ltd. All rights reserved.
- リンク情報
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- DOI
- https://doi.org/10.1016/j.vaccine.2017.04.009
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/28431812
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000401391500013&DestApp=WOS_CPL
- URL
- https://www.sciencedirect.com/science/article/pii/S0264410X17304693?via%3Dihub
- ID情報
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- DOI : 10.1016/j.vaccine.2017.04.009
- ISSN : 0264-410X
- eISSN : 1873-2518
- PubMed ID : 28431812
- Web of Science ID : WOS:000401391500013