Mikio Kinoshita

Profile Information

Affiliation: 帯広畜産大学

Degree: 博士(農学）(東北大学)

J-GLOBAL ID: 201801000417971520
researchmap Member ID: B000305815

Research Areas

Life sciences / Food sciences /

Research History

Sep, 1998 - Sep, 1999

非常勤・特別協力研究員, 岡崎国立研究機構基礎生物学研究所
Oct, 1995 - Sep, 1998

科学技術振興機構科学技術特別研究員（国立循環器病センター研究所派遣）

Education

Apr, 1991 - Mar, 1995

食糧化学専攻博士後期課程, 農学研究科, 東北大学大学院
Apr, 1989 - Mar, 1991

Obihiro University of Agriculture and Veterinary Medicine
Apr, 1985 - Mar, 1989

Faculty of Animal Husbandry, Obihiro University of Agriculture and Veterinary Medicine

Major Papers

Dietary Alkali-stable Neutral Lipids from Sake Lees Suppress the Formation of Colon Aberrant Crypt Foci in Mice

Shinji Yamashita, Tomoya Tsuruma, Mikio Kinoshita, Teruo Miyazawa

Journal of Oleo Science, 71(3) 419-423, 2022 Peer-reviewedCorresponding author
Dietary Ethanolamine Plasmalogen Alleviates DSS-Induced Colitis by Enhancing Colon Mucosa Integrity, Antioxidative Stress, and Anti-inflammatory Responses via Increased Ethanolamine Plasmalogen Molecular Species: Protective Role of Vinyl Ether Linkages

Ephantus Nguma, Shinji Yamashita, Kyu Ho Han, Yurika Otoki, Ayaka Yamamoto, Kiyotaka Nakagawa, Michihiro Fukushima, Teruo Miyazawa, Mikio Kinoshita

Journal of Agricultural and Food Chemistry, 69(44) 13034-13044, Nov 10, 2021 Peer-reviewedLast author
Protective Mechanism of Rice-Derived Lipids and Glucosylceramide in an in Vitro Intestinal Tract Model

Shinji Yamashita, Michiru Soga, Ephantus Nguma, Mikio Kinoshita, Teruo Miyazawa

Journal of Agricultural and Food Chemistry, 69(35) 10206-10214, 2021 Peer-reviewedCorresponding author
Sake (Rice wine) brewing hydrolyzes highly polar sphingolipids to ceramides and increases free sphingoid bases

Shinji Yamashita, Chisato Higaki, Nobuhiro Kikuchi, Daisuke Suzuki, Mikio Kinoshita, Teruo Miyazawa

Journal of Oleo Science, 70(8) 1147-1156, 2021 Peer-reviewedCorresponding author
Absorption kinetics of ethanolamine plasmalogen and its hydrolysate in mice

Shinji Yamashita, Kazufumi Fujiwara, Yuki Tominaga, Ephantus Nguma, Takumi Takahashi, Yurika Otoki, Ayaka Yamamoto, Ohki Higuchi, Kiyotaka Nakagawa, Mikio Kinoshita …

Journal of Oleo Science, 70(2) 263-273, 2021 Peer-reviewedCorresponding author
Ethanolamine plasmalogen suppresses apoptosis in human intestinal tract cells in vitro by attenuating induced inflammatory stress

Ephantus Nguma, Shinji Yamashita, Kei Kumagai, Yurika Otoki, Ayaka Yamamoto, Takahiro Eitsuka, Kiyotaka Nakagawa, Teruo Miyazawa, Mikio Kinoshita

ACS Omega, 6(4) 3140-3148, 2021 Peer-reviewedLast author
Sphingolipid properties in sake rice cultivars and changes during polishing and brewing

Shinji Yamashita, Chisato Higaki, Asuka Kanai, Nobuhiro Kikuchi, Daisuke Suzuki, Mikio Kinoshita, Teruo Miyazawa

Journal of Oleo Science, 70(2) 203-212, 2021 Peer-reviewedCorresponding author
Effects of Sphingolipid Fractions from Golden Oyster Mushroom (Pleurotus citrinopileatus) on Apoptosis Induced by Inflammatory Stress in an Intestinal Tract in vitro Model.

Mirinthorn Jutanom, Chisato Higaki, Shinji Yamashita, Kiyotaka Nakagawa, Satoshi Matsumoto, Mikio Kinoshita

Journal of oleo science, 69(9) 1087-1093, Sep 2, 2020 Peer-reviewedLast author
Polar lipid fraction from golden oyster mushrooms (Pleurotus citrinopileatus) suppresses colon injuries from inflammatory stresses in vivo and in vitro

Shinji Yamashita, Takuya Seino, Miho Inobe, Mirinthorn Jutanom, Satoshi Matsumoto, Mikio Kinoshita

Journal of Oleo Science, 69(7) 751-757, 2020 Peer-reviewedCorresponding author
Effects of dietary ethanol extracts from sake rice and sake lees on intestinal impairment in mice

Shinji Yamashita, Mariko Hata, Nobuhiro Kikuchi, Mikio Kinoshita, Teruo Miyazawa

Journal of Oleo Science, 69(8) 929-939, 2020 Peer-reviewedCorresponding author
Extraction of lipophilic fraction from polished rice improves its ameliorative effect on intestinal impairment

Shinji Yamashita, Masahiro Yamamoto, Kenta Hirakawa, Nobuhiro Kikuchi, Mikio Kinoshita, Teruo Miyazawa

Journal of Oleo Science, 68(5) 463-470, Jan, 2019 Peer-reviewedCorresponding author
Effects of Plant Sphingolipids on Inflammatory Stress in Differentiated Caco-2 Cells

Shinji Yamashita, Takuya Seinol, Kazuhiko Aida, Mikio Kinoshita

JOURNAL OF OLEO SCIENCE, 66(12) 1337-1342, Dec, 2017 Peer-reviewedCorresponding author
Effects of Dietary Plant-origin Glucosylceramide on Colon Cytokine Contents in DMH-treated Mice

Shinji Yamashita, Riho Sakurai, Kenshiro Hishiki, Kazuhiko Aida, Mikio Kinoshita

JOURNAL OF OLEO SCIENCE, 66(2) 157-160, Feb, 2017 Peer-reviewedCorresponding author
Effects of Dietary Plant-Origin Glucosylceramide on Bowel Inflammation in DSS-Treated Mice

Katsuhito Arai, Yu Mizobuchi, Yoshihiko Tokuji, Kazuhiko Aida, Shinji Yamashita, Masao Ohnishi, Mikio Kinoshita

JOURNAL OF OLEO SCIENCE, 64(7) 737-742, Jul, 2015 Peer-reviewedCorresponding author
Effects of Chinese yam storage protein on formation of aberrant crypt foci in 1,2-dimethylhydrazine-treated mice

Katsuhito Arai, Tamiko Yamazaki, Yoshihiko Tokuji, Mika Kawahara, Kiyoshi Ohba, Kazunori Hironaka, Mikio Kinoshita, Masao Ohnishi

JOURNAL OF FOOD AND NUTRITION RESEARCH, 52(3) 139-145, 2013 Peer-reviewedCorresponding author
Effects of dietary glucosylceramide on dermatitis in atopic dermatitis model mice

Jisaburo Ono, Mikio Kinoshita, Kazuhiko Aida, Masahiko Tamura, Masao Ohnishi

EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY, 112(7) 708-711, Jul, 2010 Peer-reviewedCorresponding author
EFFECTS OF DIETARY PLANT CEREBROSIDE ON GENE EXPRESSION IN THE LARGE INTESTINE OF 1,2-DIMETHYLHYDRAZINE (DMH)-TREATED MICE DETERMINED BY DNA MICROARRAY ANALYSIS

Mikio Kinoshita, Kazuhiko Aida, Yoshihiko Tokuji, Tatsuya Sugawara, Masao Ohnishi

JOURNAL OF FOOD LIPIDS, 16(2) 200-208, May, 2009 Peer-reviewedLead authorCorresponding author
Effect of Dietary Chinese Yam (D. opposita Thunb.) and Leaf Juice (Aojiru) on Aberrant Crypt Foci Formation in 1, 2-Dimethylhydrazine-treated Mice

Mikio Kinoshita, Keita Yunoki, Yoshihiko Tokuji, Kiyoshi Ohba, Kazunori Hironaka, Masao Ohnishi, Mika Kawahara

JOURNAL OF THE JAPANESE SOCIETY FOR FOOD SCIENCE AND TECHNOLOGY-NIPPON SHOKUHIN KAGAKU KOGAKU KAISHI, 56(1) 53-55, 2009 Peer-reviewedLead authorCorresponding author
Prevention of aberrant crypt foci formation by dietary Chinese yam (D. opposita THUNB.) in 1,2-dimethylhydrazine-treated mice

Mikio Kinoshita, Keita Yunoki, Yoshihiko Tokuji, Mika Kawahara, Kiyoshi Ohba, Kazunori Hironaka, Masao Ohnishi

JOURNAL OF THE JAPANESE SOCIETY FOR FOOD SCIENCE AND TECHNOLOGY-NIPPON SHOKUHIN KAGAKU KOGAKU KAISHI, 55(6) 270-275, 2008 Peer-reviewedLead authorCorresponding author
Prevention of melanin formation by yeast cerebroside in B16 mouse melanoma cells.

Mikio Kinoshita, Naofumi Hori, Kazuhiko Aida, Tatsuya Sugawara, Masao Ohnishi

Journal of oleo science, 56(12) 645-648, Jan, 2007 Peer-reviewedLead authorCorresponding author
Content and Constituent Properties of Sphingolipid Classes in Saccharomyces kluyveri

KIMURA Koji, KINOSHITA Mikio, TAKAKUWA Naoya, TAMURA Masahiko, ODA Yuji, OHNISHI Masao

J Oleo Sci, 55(12) 623-627 (J-STAGE)-9, 2006 Peer-reviewedCorresponding author
Prevention of Aberrant Crypt Foci Formation by Dietary Maize and Yeast Cerebrosides in 1,2-Dimethylhydrazine-treated Mice

Kazuhiko Aida, Mikio Kinoshita, Mikio Tanji, Tatsuya Sugawara, Masahiko Tamura, Jisaburo Ono, Norimichi Ueno, Masao Ohnishi

Journal of Oleo Science, 54(1) 45-49, 2005 Peer-reviewed
Apoptosis Inducement by Plant and Fungus Sphingoid Bases in Human Colon Cancer Cells

Kazuhiko Aida, Mikio Kinoshita, Tatsuya Sugawara, Jisaburo Ono, Teruo Miyazawa, Masao Ohnishi

Journal of Oleo Science, 53(10) 503-510, 2004 Peer-reviewed
Existence of cerebroside in Saccharomyces kluyveri and its related species

N Takakuwa, M Kinoshita, Y Oda, M Ohnishi

FEMS YEAST RESEARCH, 2(4) 533-538, Dec, 2002 Peer-reviewed
Age-related increases in plasma phosphatidyicholine hydroperoxide concentrations in control subjects and patients with hyperlipidemia

Mikio Kinoshita, Shinichi Oikawa, Kyoko Hayasaka, Akihiro Sekikawa, Tazuko Nagashima, Takayoshi Toyota, Teruo Miyazawa

Clinical Chemistry, 46(6) 822-828, 2000 Peer-reviewedLead author
Autocrine FGF-2 is responsible for the cell density-dependent susceptibility to apoptosis of HUVEC: A role of a calpain inhibitor-sensitive mechanism

Mikio Kinoshita, Kentaro Shimokado

Arteriosclerosis, Thrombosis, and Vascular Biology, 19(10) 2323-2329, 1999 Peer-reviewedLead author
Oxidized low density lipoprotein induces apoptosis in cultured human umbilical vein endothelial cells by common and unique mechanisms

M Harada-Shiba, M Kinoshita, H Kamido, K Shimokado

JOURNAL OF BIOLOGICAL CHEMISTRY, 273(16) 9681-9687, Apr, 1998 Peer-reviewed
Structure and Distribution of Cerebroside Containing Unsaturated Hydroxy Fatty Acids in Plant Leaves

Masao Ohnishi, Michiyuki Kojima, Seisuke Ito, Hiroyuki Imai, Mikio Kinoshita

Bioscience, Biotechnology, and Biochemistry, 59(7) 1309-1313, 1995 Peer-reviewed

Major Misc.

Dietary sphingolipids contribute to health via intestinal maintenance

Shinji Yamashita, Mikio Kinoshita, Teruo Miyazawa

International Journal of Molecular Sciences, 22(13), Jul 1, 2021 Peer-reviewed

Books and Other Publications

脂質・酸化脂質分析法入門

山下, 慎司, 宮澤, 大樹, 木下, 幹朗, 宮澤, 陽夫

幸書房, Apr, 2023 (ISBN: 9784782104736)
セラミド研究の新展開 : 基礎から応用へ

セラミド研究会 (Role: Contributor)

食品化学新聞社, 2019 (ISBN: 9784916143358)
セラミド : 基礎と応用ここまできたセラミド研究最前線

セラミド研究会 (Role: Contributor)

食品化学新聞社, 2011 (ISBN: 9784916143211)

Professional Memberships

Research Projects

植物由来スフィンゴ脂質の消化管への機能性に関する研究

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, 2008 - 2010

木下幹朗
植物由来スフィンゴ脂質の大腸ガン細胞に対する機能に関する研究

科学研究費助成事業若手研究(B), 若手研究(B), 日本学術振興会, 2003 - 2004

木下幹朗
食餌性植物スフィンゴ脂質の動態および生理作用に関する研究

科学研究費助成事業若手研究(B), 若手研究(B), 日本学術振興会, 2001 - 2002

木下幹朗

Industrial Property Rights

特開2022-089623 アミド化合物の分解方法及びアミンの製造方法

有福征宏, 曽根圭太, 上田俊輔, 小林久美子, 山下慎司, 檜垣知里, 木下幹朗, 宮下和夫
特開2022-089621 配糖体の分解方法及びアグリコンの製造方法

曽根圭太, 有福征宏, 上田俊輔, 小林久美子, 山下慎司, 檜垣知里, 木下幹朗, 宮下和夫
特許第4962754号抗腫瘍剤、腫瘍細胞増殖抑制剤、免疫賦活剤及び食品

間和彦, 木下幹朗, 大西正男, 小野治三郎
特開2011-173813 PPARα発現促進剤

柚木恵太, 大西正男, 木下幹朗, 杉山雅昭, 小玉芳郎, 府中英孝
特許第4783550号大腸ガン抑制剤及びそれを含む食品

間和彦, 木下幹朗, 大西正男, 小野治三郎
特許第4776163号大腸ガン抑制剤及びそれを含む食品

間和彦, 木下幹朗, 大西正男, 小野治三郎, 田村雅彦
特開2011-051914 低温殺菌処理ホエータンパク濃縮物を含む腸管炎症抑制剤

木下幹朗, 大西正男, 木村幸史, 田中一郎, 岩附聡
特開2009-029748 ナガイモを用いた大腸ガン抑制剤

木下幹朗, 柚木恵太, 得字圭彦, 弘中和憲, 大西正男, 川原美香, 大庭潔
特開2007-099626 サーファクチンを含有する農作物のそうか病防除用組成物

大和田琢ニ, 木下幹朗, 佐伯雄史, 小村啓
特許第3902215号サーファクチンを含有する農作物のそうか病防除用組成物

大和田琢ニ, 木下幹朗, 佐伯雄史, 小村啓
特開2006-328041 抗腫瘍剤、腫瘍細胞増殖抑制剤、免疫賦活剤及び食品

間和彦, 木下幹朗, 大西正男, 小野治三郎
特開2005-187391 大腸ガン抑制剤及びそれを含む食品

間和彦, 木下幹朗, 大西正男, 小野治三郎
特開2005-187392 大腸ガン抑制剤及びそれを含む食品

間和彦, 木下幹朗, 大西正男, 小野治三郎, 田村雅彦
特開2003-245070 脂肪酸不飽和化酵素を有する形質転換動物およびその作製方法

佐伯和弘, 松本和也, 木下幹朗, 鈴木石根, 田口善智, 三上浩司, 上田正次, 細井美彦, 村田紀夫, 入谷明, 加野浩一郎

Profile Information

Research Areas

Research History

Education

Major Papers

Major Misc.

Books and Other Publications

Professional Memberships

Research Projects

Industrial Property Rights

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