平岡桐子 (Kiriko Hiraoka) - マイポータル

基本情報

所属: 公益財団法人かずさDNA研究所広報・研究推進グループ主任研究員

学位: 医学博士(2017年3月千葉大学大学院医学研究院)

連絡先: khiraokakazusa.or.jp
J-GLOBAL ID: 202001009704643369
researchmap会員ID: R000014155

論文

Targeting the mutant PIK3CA gene by DNA‐alkylating pyrrole imidazole polyamide in cervical cancer

Sakthisri Krishnamurthy, Hiroyuki Yoda, Kiriko Hiraoka, Takahiro Inoue, Jason Lin, Yoshinao Shinozaki, Takayoshi Watanabe, Nobuko Koshikawa, Atsushi Takatori, Hiroki Nagase

Cancer Science 112(3) 1141-1149 2020年12月29日
Depletion of runt-related transcription factor 2 (RUNX2) enhances SAHA sensitivity of p53-mutated pancreatic cancer cells through the regulation of mutant p53 and TAp63.

Takehiro Ogata, Mizuyo Nakamura, Meijie Sang, Hiroyuki Yoda, Kiriko Hiraoka, Danjing Yin, Mexiang Sang, Osamu Shimozato, Toshinori Ozaki

PloS one 12(7) e0179884 2017年
Depletion of pro-oncogenic RUNX2 enhances gemcitabine (GEM) sensitivity of p53-mutated pancreatic cancer Panc-1 cells through the induction of pro-apoptotic TAp63.

Toshinori Ozaki, Mizuyo Nakamura, Takehiro Ogata, Meijie Sang, Hiroyuki Yoda, Kiriko Hiraoka, Meixiang Sang, Osamu Shimozato

Oncotarget 7(44) 71937-71950 2016年11月1日
Improvement of gemcitabine sensitivity of p53-mutated pancreatic cancer MiaPaCa-2 cells by RUNX2 depletion-mediated augmentation of TAp73-dependent cell death

M Nakamura, H Sugimoto, T Ogata, K Hiraoka, H Yoda, M Sang, M Sang, Y Zhu, M Yu, O Shimozato …

Oncogenesis 5(6) e233-e233 2016年6月
Identification of Binding Targets of a Pyrrole-Imidazole Polyamide KR12 in the LS180 Colorectal Cancer Genome.

Jason Lin, Kiriko Hiraoka, Takayoshi Watanabe, Tony Kuo, Yoshinao Shinozaki, Atsushi Takatori, Nobuko Koshikawa, Anandhakumar Chandran, Joe Otsuki, Hiroshi Sugiyama …

PloS one 11(10) e0165581 2016年
Silencing of RUNX2 enhances gemcitabine sensitivity of p53-deficient human pancreatic cancer AsPC-1 cells through the stimulation of TAp63-mediated cell death

H Sugimoto, M Nakamura, H Yoda, K Hiraoka, K Shinohara, M Sang, K Fujiwara, O Shimozato, H Nagase, T Ozaki

Cell Death & Disease 6(10) e1914-e1914 2015年10月
Precise mapping and dynamics of tRNA-derived fragments (tRFs) in the development of Triops cancriformis (tadpole shrimp).

Yuka Hirose, Kahori T Ikeda, Emiko Noro, Kiriko Hiraoka, Masaru Tomita, Akio Kanai

BMC genetics 16 83-83 2015年7月14日
Inhibition of KRAS codon 12 mutants using a novel DNA-alkylating pyrrole-imidazole polyamide conjugate.

Kiriko Hiraoka, Takahiro Inoue, Rhys Dylan Taylor, Takayoshi Watanabe, Nobuko Koshikawa, Hiroyuki Yoda, Ken-ichi Shinohara, Atsushi Takatori, Hirokazu Sugimoto, Yoshiaki Maru …

Nature communications 6 6706-6706 2015年4月27日
Identification, expression, and molecular evolution of microRNAs in the "living fossil" Triops cancriformis (tadpole shrimp).

Kahori T Ikeda, Yuka Hirose, Kiriko Hiraoka, Emiko Noro, Kosuke Fujishima, Masaru Tomita, Akio Kanai

RNA (New York, N.Y.) 21(2) 230-42 2015年2月
Double β-alanine Substitutions Incorporated in 12-ring Pyrrole-Imidazole Polyamides for Lengthened DNA Minor Groove Recognition

Takayoshi Watanabe, Ken-ichi Shinohara, Yoshinao Shinozaki, Syota Uekusa, Xiaofei Wang, Nobuko Koshikawa, Kiriko Hiraoka, Takahiro Inoue, Jason Lin, Toshikazu Bando …

Advanced Techniques in Biology & Medicine 04(02) 2015年
Runt-related transcription factor 2 attenuates the transcriptional activity as well as DNA damage-mediated induction of pro-apoptotic TAp73 to regulate chemosensitivity.

Toshinori Ozaki, Hirokazu Sugimoto, Mizuyo Nakamura, Kiriko Hiraoka, Hiroyuki Yoda, Meixiang Sang, Kyoko Fujiwara, Hiroki Nagase

The FEBS journal 282(1) 114-28 2015年1月
A screening system for artificial small RNAs that inhibit the growth of Escherichia coli.

Mizuki Komasa, Kosuke Fujishima, Kiriko Hiraoka, Atsuko Shinhara, Baek-Seok Lee, Masaru Tomita, Akio Kanai

Journal of biochemistry 150(3) 289-94 2011年9月
Deep sequencing reveals as-yet-undiscovered small RNAs in Escherichia coli.

Atsuko Shinhara, Motomu Matsui, Kiriko Hiraoka, Wataru Nomura, Reiko Hirano, Kenji Nakahigashi, Masaru Tomita, Hirotada Mori, Akio Kanai

BMC genomics 12 428-428 2011年8月24日

MISC

Novel Therapeutic Strategy to Target the Amplified Genomic Region of Oncogenes in Childhood Cancers

Atsushi Takatori, Hiroyuki Yoda, Kiriko Hiraoka, Sakthisri Krishnamurthy, Takayoshi Watanabe, Yoshinao Shinozaki, Hiroki Nagase

PEDIATRIC BLOOD & CANCER 64 S114-S114 2017年11月
Mutated cancer cell-specific cell death activity of alkylating Pyrrole-Imidazole polyamide conjugates targeting a variety of oncogenic driver gene mutations

Hiroki Nagase, Kiriko Hiraoka, Takahiro Inoue, Hiroyuki Yoda, Krishnamurthy Sakthisri, Jason Lin, Takayoshi Watanabe, Nobuko Koshikawa, Atsushi Takatori

CANCER RESEARCH 76 2016年7月
A novel alkylating pyrrol-imidazole polyamide, KR12, specifically recognizes mutant KRAS genes and potently induces cell death

Kiriko Hiraoka, Takahiro Inoue, Hiroyuki Yoda, Atsushi Takatori, Takayoshi Watanabe, Nobuko Koshikawa, Toshinori Ozaki, Hiroki Nagase

CANCER RESEARCH 75 2015年8月
KRAS mutation specific alkylating pyrrole-imidazole polyamide (KR12) suppresses mutant KRAS expression and inhibits tumor growth by showing accumulation in KRAS mutant xenografts

Takahiro Inoue, Kiriko Hiraoka, Yusei Suzuki, Hiroyuki Yoda, Takayoshi Watanabe, Atsushi Takatori, Nobuko Koshikawa, Toshinori Ozaki, Hiroki Nagase

CANCER RESEARCH 75 2015年8月
KRAS G12D and G12V specific alkylating agent (KR12) inhibits growth of colon cancer with those KRAS mutations in vitro as well as in vivo

Hiroki Nagase, Kiriko Hiraoka, Takahiro Inoue, Takayoshi Watanabe, Ken-Ichi Shinohara, Nobuko Koshikawa, Ozaki Toshinori

CANCER RESEARCH 74(19) 2014年10月

講演・口頭発表等

A novel alkylating pyrrol-imidazole polyamide, KR12, specifically recognizes mutant KRAS genes and potently induces cell death.

Kiriko Hiraoka, Takahiro Inoue, Hiroyuki Yoda, Atsushi Takatori, Takayoshi Watanabe, Nobuko Koshikawa, Toshinori Ozaki, Hiroki Nagase

AACR Annual Meeting 2015 2015年4月22日

平岡桐子

基本情報

論文

MISC

講演・口頭発表等

メニュー

共著者の一覧