論文

査読有り
2021年6月

Clinical Outcome of Palliative Concurrent Chemoradiotherapy with Cisplatin/Docetaxel for Stage III Non-small Cell Lung Cancer.

Acta medica Okayama
  • Kuniaki Katsui
  • ,
  • Takeshi Ogata
  • ,
  • Kenta Watanabe
  • ,
  • Kotaro Yoshio
  • ,
  • Masahiro Kuroda
  • ,
  • Takao Hiraki
  • ,
  • Katsuyuki Kiura
  • ,
  • Yoshinobu Maeda
  • ,
  • Shinichi Toyooka
  • ,
  • Susumu Kanazawa

75
3
開始ページ
269
終了ページ
277
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.18926/AMO/62218

Palliative concurrent chemoradiotherapy (CCRT) is often administered to patients with stage III non-small cell lung cancer (NSCLC). We investigated the clinical outcomes of patients receiving palliative CCRT for NSCLC. Data of patients with NSCLC who underwent palliative CCRT (n=16), preoperative CCRT plus surgery (n=97), or definitive CCRT (n=48) were evaluated. In all groups, the concurrent chemotherapy regimens consisted of cisplatin and docetaxel. Rates of local control (LC), distant metastasis-free survival (DMFS), progression-free survival (PFS), overall survival (OS), and prognosis were compared. The 2-year rates of LC, DMFS, PFS, and OS in 16 patients who underwent palliative CCRT were 44.4%, 12.5%, 12.5%, and 18.8%, respectively. Univariate analysis showed that palliative CCRT was associated with poor LC (p<0.001), DMFS (p<0.001), PFS (p<0.001), and OS (p<0.001) outcomes in patients who completed CCRT as a preoperative treatment and poor LC (p=0.01), DMFS (p=0.003), PFS (p=0.04), and OS (p=0.004) outcomes in patients who were considered for definitive CCRT. Although there were some long-term survivors, the clinical outcomes of palliative CCRT were significantly inferior to those of the ideal treatments. Therefore, careful determination of the appropriate treatment indications and further studies are warranted.

リンク情報
DOI
https://doi.org/10.18926/AMO/62218
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/34176930
ID情報
  • DOI : 10.18926/AMO/62218
  • PubMed ID : 34176930

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