論文

査読有り 国際誌
2018年3月

Lysophosphatidic acid in medicinal herbs enhances prostaglandin E2 and protects against indomethacin-induced gastric cell damage in vivo and in vitro.

Prostaglandins & other lipid mediators
  • Sheuli Afroz
  • Ayano Yagi
  • Kouki Fujikawa
  • M Motiur Rahman
  • Katsuya Morito
  • Tatsuya Fukuta
  • Shiro Watanabe
  • Emi Kiyokage
  • Kazunori Toida
  • Taro Shimizu
  • Tatsuhiro Ishida
  • Kentaro Kogure
  • Akira Tokumura
  • Tamotsu Tanaka
  • 全て表示

135
開始ページ
36
終了ページ
44
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.prostaglandins.2018.01.003

Lysophosphatidic acid (LPA) is a bioactive phospholipid that induces diverse biological responses. Recently, we found that LPA ameliorates NSAIDs-induced gastric ulcer in mice. Here, we quantified LPA in 21 medicinal herbs used for treatment of gastrointestinal (GI) disorders. We found that half of them contained LPA at relatively high levels (40-240 μg/g) compared to soybean seed powder (4.6 μg/g), which we previously identified as an LPA-rich food. The LPA in peony (Paeonia lactiflora) root powder is highly concentrated in the lipid fraction that ameliorates indomethacin-induced gastric ulcer in mice. Synthetic 18:1 LPA, peony root LPA and peony root lipid enhanced prostaglandin E2 production in a gastric cancer cell line, MKN74 cells that express LPA2 abundantly. These materials also prevented indomethacin-induced cell death and stimulated the proliferation of MKN74 cells. We found that LPA was present in stomach fluids at 2.4 μM, which is an effective LPA concentration for inducing a cellular response in vitro. These results indicated that LPA is one of the active components of medicinal herbs for the treatment of GI disorder and that orally administered LPA-rich herbs may augment the protective actions of endogenous LPA on gastric mucosa.

リンク情報
DOI
https://doi.org/10.1016/j.prostaglandins.2018.01.003
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29462674
ID情報
  • DOI : 10.1016/j.prostaglandins.2018.01.003
  • ISSN : 1098-8823
  • PubMed ID : 29462674

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