論文

2016年9月22日

Clinical significance of mucinous components in rectal cancer after preoperative chemoradiotherapy.

Surgery today
  • Kaneko K
  • Kawai K
  • Kazama S
  • Murono K
  • Sasaki K
  • Yasuda K
  • Ohtani K
  • Nishikawa T
  • Tanaka T
  • Kiyomatsu T
  • Keisuke Hata
  • Nozawa H
  • Ishihara S
  • Morikawa T
  • Fukayama M
  • Watanabe T
  • 全て表示

記述言語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s00595-016-1419-0

<h4>Purpose</h4>The clinical implications of mucinous components in rectal tumors, especially with regard to the efficacy of neoadjuvant chemoradiotherapy, remain unclear.<h4>Methods</h4>One hundred and thirty rectal cancer patients who received curative resection after neoadjuvant chemoradiotherapy were retrospectively reviewed. Patients were classified into 3 groups according to the proportion of extracellular mucin: low (<5 %), moderate (5-25 %), and high (>25 %).<h4>Results</h4>There were 82 (63.1 %), 26 (20.0 %), and 22 (16.9 %) patients in the low, moderate, and high mucin groups, respectively. Patients with a high mucinous tumor component were significantly more likely to have an advanced tumor stage (p = 0.010) and a shorter disease-free (p = 0.002) and distant recurrence-free survivals (p < 0.001), whereas the mucinous tumor component showed no correlation with local recurrence (p = 0.101). A high mucinous component was also an independent predictive factor for a shorter disease-free survival (p = 0.041, hazard ratio = 2.56) and distant recurrence-free survival (p = 0.001, hazard ratio = 5.74) according to a multivariate analysis.<h4>Conclusions</h4>Because the mucinous components showed little correlation with local recurrence, mucinous cancer should not be a determining factor for chemoradiotherapy. However, the frequent occurrence of metachronous distant metastasis among patients with a high mucin component makes this a possible indicator for more robust postoperative adjuvant treatment and close surveillance of recurrence.

リンク情報
DOI
https://doi.org/10.1007/s00595-016-1419-0
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27659290
ID情報
  • DOI : 10.1007/s00595-016-1419-0
  • ORCIDのPut Code : 136783626
  • PubMed ID : 27659290

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