論文

査読有り
2019年2月

Calvarial Bone Implantation and in vivo Imaging of Tumor Cells in Mice

BIO-PROTOCOL
  • Kyoko Hashimoto
  • ,
  • Shingo Sato
  • ,
  • Hiroki Ochi
  • ,
  • Shu Takeda
  • ,
  • Mitsuru Futakuchi

9
3
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.21769/BioProtoc.3151
出版者・発行元
BIO-PROTOCOL

Bone is one of common metastasis sites for many types of cancer. In bone metastatic microenvironment, tumor-bone interactions play a significant role in the regulation of osteolytic or osteoblastic bone metastasis. In order to investigate the direct interaction between tumor cells and bone tissue, it is essential to generate appropriate animal models that mimic the behavior of tumor cells in bone metastatic lesions. Calvarial implantation model (bone invasion model) is a newly-established animal model that accurately recapitulates the behavior of tumor cells in the tumor-bone microenvironment. The surgical technique for tumor cell implantation is simpler than intracardiac, intra-arterial, or intraosseous injection techniques. This model can be useful for the identification of key factors driving tumor-induced osteolytic or osteoblastic changes.


リンク情報
DOI
https://doi.org/10.21769/BioProtoc.3151
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000458033700001&DestApp=WOS_CPL

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