Kenichiro Koshiyama

Profile Information

Affiliation: 招へい教員, 大阪大学大学院基礎工学研究科

Degree: 博士（工学）(北海道大学)

J-GLOBAL ID: 201601004554810232
researchmap Member ID: B000267923

External link: https://sites.google.com/site/drkklab/

Research Areas

Life sciences / Biomedical engineering /

Awards

Sep, 2017

2016 JBSE GRAPHICS OF THE YEAR AWARD, Line tension of the pore edge in phospholipid/cholesterol bilayer from stretch molecular dynamics simulation, 日本機械学会バイオエンジニアリング部門

重松大輝, Koshiyama Kenichiro, 和田成生
Sep, 2017

2016 JBSE Papers of the Year Award, Line tension of the pore edge in phospholipid/cholesterol bilayer from stretch molecular dynamics simulation, 日本機械学会バイオエンジニアリング部門

重松大輝, Koshiyama Kenichiro, 和田成生
Feb, 2015

大阪大学総長奨励賞(研究部門), Osaka University

Koshiyama Kenichiro
Sep, 2013

日本機械学会マイクロ・ナノ工学部門優秀講演論文表彰, 「超音波作用下での脂質膜構造変化:分子動力学シミュレーション」, 日本機械学会マイクロ・ナノ工学部門

Koshiyama Kenichiro
Feb, 2011

日本機械学会計算力学部門優秀講演表彰, 「細胞の高速な変形に伴う膜破断:分子動力学シミュレーション」, 日本機械学会計算力学部門

Koshiyama Kenichiro
Apr, 2009

日本機械学会奨励賞, 「衝撃波による細胞膜の透過性変化および分子導入の分子的機構の研究」, Japan Society of Mechanical Engineers

Koshiyama Kenichiro

Papers

Changes in free energy barrier for water permeation by stretch-induced phase transitions in phospholipid/cholesterol bilayers

Taiki Shigematsu, Kenichiro Koshiyama

Journal of Biomolecular Structure and Dynamics, 1-8, Sep 1, 2023
Shear-flow-induced negative tension of phospholipid bilayer: Molecular dynamics simulation

Taiki Shigematsu, Kenichiro Koshiyama

The Journal of Chemical Physics, 159(1), Jul 5, 2023
Mathematical modeling of pulmonary acinus structure: Verification of acinar shape effects on pathway structure using rat lungs.

Ishikawa Atsuki, Koshiyama Kenichiro

Respiratory Physiology & Neurobiology, Vol.302, Mar, 2022 Peer-reviewed
Prediction of airway deformation effect on pulmonary air-particle dynamics: A numerical study

Jianan Zhao, Yu Feng, Koshiyama Kenichiro, Huimin Wu

Physics of Fluids, Vol.33 101906-101906, Oct 21, 2021 Peer-reviewed
せん断流れ下での脂質二重膜のダイナミクス:分子動力学シミュレーション

重松大樹, Koshiyama Kenichiro

Journal of Japan Society of Fluid Mechanics, Vol.39 340-343, Dec, 2020 Invited
Kelvin-Helmholtz-like instability of phospholipid bilayers under shear flow: System-size dependence.

Shigematsu Taiki, Koshiyama Kenichiro, Wada Shigeo

Physical Review E, Vol.102(No.2-1) 022408-022408, Aug, 2020 Peer-reviewed
Targeting inhaled fibers to the pulmonary acinus: Opportunities for augmented delivery from in silico simulations

Shachar-Berman Lihi, Ostrovski Yan, Koshiyama Kenichiro, Wada Shigeo, Kassinos C. Stavros, Sznitman Josué

European Journal of Pharmaceutical Sciences, Vol.137 105003-105003, Sep, 2019 Peer-reviewed
Bicelle-to-Vesicle Transition of a Binary Phospholipid Mixture Guided by Controlled Local Lipid Compositions: A Molecular Dynamics Simulation Study.

Koshiyama Kenichiro, Taneo Masaki, Shigematsu Taiki, Wada Shigeo

The Journal of Physical Chemistry B, Vol.123(No.14) 3118-3123, Mar 28, 2019 Peer-reviewed
Stretch-Induced Interdigitation of a Phospholipid/Cholesterol Bilayer.

Shigematsu T, Koshiyama K, Wada S

The journal of physical chemistry. B, 122(9) 2556-2563, Mar, 2018 Peer-reviewed
One (sub-)acinus for all: Fate of inhaled aerosols in heterogeneous pulmonary acinar structures

Philipp Hofemeier, Kenishiro Koshiyama, Shigeo Wada, Josué Sznitman

European Journal of Pharmaceutical Sciences, 113 53-63, Feb 15, 2018 Peer-reviewed
Heterogeneous structure and surface tension effects on mechanical response in pulmonary acinus: A finite element analysis.

Kenichiro Koshiyama, Keisuke Nishimoto, Satoshi Ii, Toshihiro Sera, Shigeo Wada

Clinical biomechanics (Bristol, Avon), 66 32-39, Jan 20, 2018 Peer-reviewed
Morphological Characterization of Acinar Cluster in Mouse Lung Using a Multiscale-based Segmentation Algorithm on Synchrotron Micro-CT Images

Luosha Xiao, Toshihiro Sera, Kenichiro Koshiyama, Shigeo Wada

Anatomical Record, 299(10) 1424-1434, Oct 1, 2016 Peer-reviewed
Collapse of a lipid-coated nanobubble and subsequent liposome formation

Kenichiro Koshiyama, Shigeo Wada

SCIENTIFIC REPORTS, 6, Jun, 2016 Peer-reviewed
Line tension of the pore edge in phospholipid/cholesterol bilayer from stretch molecular dynamics simulation

Taiki Shigematsu, Kenichiro Koshiyama, Shigeo Wada

Journal of Biomechanical Science and Engineering, 11(1) 15-00422-15-00422, 2016 Peer-reviewed
個別化・予防医療での新たなパラダイムの創出健康・医療ビッグデータとスーパーコンピュータがもたらすもの医学と生体力学をむすぶデータ同化シミュレーション

和田成生, 伊井仁志, 越山顕一郎

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 88回・38回 [4W12-5], Dec, 2015
Effects of Stretching Speed on Mechanical Rupture of Phospholipid/Cholesterol Bilayers: Molecular Dynamics Simulation

Taiki Shigematsu, Kenichiro Koshiyama, Shigeo Wada

SCIENTIFIC REPORTS, 5, Oct, 2015 Peer-reviewed
Mathematical model of a heterogeneous pulmonary acinus structure

Kenichiro Koshiyama, Shigeo Wada

Computers in Biology and Medicine, 62 25-32, Jul 1, 2015 Peer-reviewed
Computational studies on strain transmission from a collagen gel construct to a cell and its internal cytoskeletal filaments

Yoshihiro Ujihara, Masanori Nakamura, Masatsugu Soga, Kenichiro Koshiyama, Hiroshi Miyazaki, Shigeo Wada

Computers in Biology and Medicine, 56 20-29, Jan 1, 2015 Peer-reviewed
Molecular dynamics simulations of pore formation in stretched phospholipid/cholesterol bilayers

Taiki Shigematsu, Kenichiro Koshiyama, Shigeo Wada

CHEMISTRY AND PHYSICS OF LIPIDS, 183 43-49, Oct, 2014 Peer-reviewed
3P213 Hydrophobic Pore Formation in Phospholipid/Cholesterol Bilayers under Mechanical Stretching: Molecular Dynamics Simulation(Biological & Artificial membrane: Dynamics,Poster,The 52th Annual Meeting of the Biophysical Society of Japan(BSJ2014))

Taiki Shigematsu, Kenichiro Koshiyama, Shigeo Wada

Seibutsu Butsuri, 54(1) S284, 2014

Misc.

Nonequilibrium Molecular Dynamics Study of Lipid Bilayers for the Development of Biomedical Engineering Techniques

Koshiyama Kenichiro

MEMBRANE, Vol.45(No.5) 226-231, 2020 Invited
Mechanical Analysis of Pulmonary Acinar Inflation: Toward Understanding Infant Acinar Mechanics

越山顕一朗, 和田成生, 伊井仁志, 世良俊博

バイオエンジニアリング講演会講演論文集(CD-ROM), 32nd, 2019
Understanding the lung crackle sounds by fluid-structure-acoustic interaction analysis

伊井仁志, 伊井仁志, 竹田圭佑, 越山顕一朗, 和田成生

計算工学講演会論文集(CD-ROM), 23, 2018
気道および肺実質内の音響伝播モデルを用いた肺音伝播メカニズムの考察

竹田圭佑, 伊井仁志, 吉永司, 越山顕一朗, 和田成生

バイオエンジニアリング講演会講演論文集(CD-ROM), 31st, 2018
肺実形状に基づいた気道分岐モデルを用いた気道内の音響解析

竹田圭佑, 吉永司, 越山顕一朗, 伊井仁志, 和田成生

日本機械学会バイオフロンティア講演会講演論文集(CD-ROM), 28th, 2017
不均質構造を有する肺細葉数理モデルを用いた構造解析

西本圭佑, 越山顕一朗, 伊井仁志, 和田成生

バイオエンジニアリング講演会講演論文集(CD-ROM), 30th, 2017
肺実形状に基づいた肺葉内気道分岐モデルを用いた肺音分布の音響解析

竹田圭佑, 吉永司, 越山顕一朗, 伊井仁志, 和田成生

バイオエンジニアリング講演会講演論文集(CD-ROM), 30th, 2017
プロトフィブリル凝集モデルを用いたフィブリン凝集塊形成シミュレーション:凝集塊の形態学的特徴の評価

榎崎凌伍, 伊井仁志, 武石直樹, 越山顕一朗, 重松大輝, 和田成生

バイオエンジニアリング講演会講演論文集(CD-ROM), 30th, 2017
離散要素を用いたフィブリン凝集塊形成におけるメゾスコピック数値アプローチ

榎崎凌伍, 伊井仁志, 武石直樹, 越山顕一朗, 重松大輝, 和田成生

日本機械学会計算力学講演会論文集(CD-ROM), 30th, 2017
1H15 Real time observations of the molecular delivery in in vitro sonoporation : effects of ultrasound conditions on the delivery timing

ANDO Naoya, KOSHIYAMA Kenichiro, KINOSHITA Manabu, WADA Shigeo

2016(28) "1H15-1"-"1H15-5", Jan 9, 2016
不均質肺細葉構造の表面張力効果を考慮した変形解析

西本圭佑, 越山顕一朗, 伊井仁志, 和田成生

日本機械学会バイオフロンティア講演会講演論文集, 27th, 2016
0313 Molecular Dynamics Simulations of Lipid Coated Nanobubble

KOSHIYAMA Kenichiro, WADA Shigeo

Fluids engineering conference ..., 2015 "0313-1"-"0313-2", Nov 7, 2015
B211 Coarse grained molecular dynamics simulations of nano-liposome rupture induced by mechanical stresses

KURUMATANI Ryotaro, SHIGEMATSU Taiki, KOSHIYAMA Kenichiro, WADA Shigeo

Proceedings of the ... JSME Conference on Frontiers in Bioengineering, 2015(26) 121-122, Oct 1, 2015
PS1-15 MICRO-CT-BASED MORPHOLOGICAL MEASUREMENT OF MOUSE ACINAR CLUSTER AND THE OXYGEN DIFFUSION ANALYSIS(PS1: Poster Short Presentation I,Poster Session)

Xiao Luosha, Sera Toshihiro, Koshiyama Kenichiro, Wada Shigeo

Proceedings of the ... Asian Pacific Conference on Biomechanics : emerging science and technology in biomechanics, 2015(8) 236-236, Sep 16, 2015
PS3-5 MOLECULAR PERSPECTIVE OF WATER PERMEABILITY CHANGES IN PHOSPHOLIPID/CHOLESTEROL BILAYER UNDER MECHANICAL STRESSES(PS3: Poster Short Presentation III,Poster Session)

Shigematsu Taiki, Koshiyama Kenichiro, Kurumatani Ryotaro, Wada Shigeo

Proceedings of the ... Asian Pacific Conference on Biomechanics : emerging science and technology in biomechanics, 2015(8) 266-266, Sep 16, 2015
J0270201 Molecular Dynamics Study about Water Permeability Change of Lipid Membranes under Stretching : toward Development of Liposomes for Drug Delivery

KURUMATANI Ryotaro, SHIGEMATSU Taiki, KOSHIYAMA Kenichiro, WADA Shigeo

Mechanical Engineering Congress, Japan, 2015 "J0270201-1"-"J0270201-5", Sep 13, 2015
617 Mutual Effects of Cholesterol and Stretching Speed on Rupture of Phospholipid Bilayers under Stretching : Molecular Dynamics Simulation

SHIGEMATSU Taiki, KOSHIYAMA Kenichiro, WADA Shigeo

2015(90) 259-260, Mar 16, 2015
P016 A blood-clot formation model considering biochemical reactions and viscoelasticity of thrombus

ISHIDA Yukiho, II Satoshi, HIRAKATA Hideo, SUGITA Naoko, KOSHIYAMA Kenichiro, WADA Shigeo

2015(90) 434-434, Mar 16, 2015
2F33 Modeling of heterogeneous micro vasculature network at the pulmonary acinus level

NISHIKAWA Asuka, KOSHIYAMA Kenichiro, WADA Shigeo

2015(27) 535-536, Jan 8, 2015
1C42 Molecular dynamics simulation of water permeability through stretched phospholipid/cholesterol bilayer

SHIGEMATSU Taiki, KOSHIYAMA Kenichiro, WADA Shigeo

2015(27) 127-128, Jan 8, 2015

Books and Other Publications

生命科学で使える初めての数理モデルとシミュレーション

Koshiyama Kenichiro

YODOSHA CO., LTD., Mar, 2017
マイクロ/ナノカプセルの調製，徐放性制御と応用事例

Koshiyama Kenichiro

Technical Information Institute Co., Ltd., Oct, 2014

Presentations

肺細葉構造の数理モデル開発:肺胞・気道領域の制御に向けた改良

Fujita Kensuke, Ryo SHINTAROH, Koshiyama Kenichiro

日本機械学会第35回バイオエンジニアリング講演会抄録集, Jun 4, 2023
局所力学物性制御によるナノリポソーム形成の誘導

Koshiyama Kenichiro

日本機械学会第35回バイオエンジニアリング講演会抄録集, Jun 3, 2023
肺胞壁発達を考慮した肺細葉構造の数理アルゴリズムの提案:周産期仔肺細葉構造モデリングに向けて

Koshiyama Kenichiro, Ryo Shintaroh, Fujita Kensuke

第30回バイオフィジオロジー研究会抄録集, Mar 17, 2023
Planar Shock Wave Interaction with nanoliposome: Molecular Dynamics Simulations

Koshiyama Kenichiro

2022年度衝撃波シンポジウム講演論文集, Mar 10, 2023
Effects of Lipid Compositions on Lipid Monolayer Buckling: Molecular Dynamics Study

岸上夏輝, Koshiyama Kenichiro

日本機械学会第33回バイオフロンティア講演会講演論文集, Dec 17, 2022, Japan Society of Mechanical Engineers
Molecular Dynamics Study of Transition from Bicelle to Vesicle Induced by Changing Local Mechanical Properties: Effects of Lipid Saturation

仲田一輝, Koshiyama Kenichiro

日本機械学会第33回バイオフロンティア講演会講演論文集, Dec 17, 2022, Japan Society of Mechanical Engineers
Identifying Material Model of Lung Tissues Based on Uniaxial Tensile Tests and Optimization with Finite Element Analysis: Effects of Specimen Dimension

木下敦斗, Koshiyama Kenichiro

日本機械学会第33回バイオフロンティア講演会講演論文集, Dec 17, 2022, Japan Society of Mechanical Engineers
Mathematical Modelling of Pulmonary Acinus Structure Representing Lung Tissue Destruction: Toward Modelling of Emphysematous Acinus

Ryo SHINTAROH, Koshiyama Kenichiro

日本機械学会第33回バイオフロンティア講演会講演論文集, Dec 17, 2022, Japan Society of Mechanical Engineers
Planar Shock Wave Interaction with a Lipid Assembly: Molecular Dynamics Simulations

Koshiyama Kenichiro

日本機械学会2022年度年次大会講演論文集, Sep 14, 2022
Mathematical Modeling of Pulmonary Acinus Structure: Extension to Neonatal Lungs

Koshiyama Kenichiro

9th World Congress of Biomechanics Taipei, Jul 13, 2022
飽和/不飽和リン脂質混合ナノリポソーム形成の分子動力学解析

仲田一輝, Koshiyama Kenichiro

日本機械学会第32回バイオフロンティア講演会講演論文集, Jan 13, 2022, Japan Society of Mechanical Engineers
肺サーファクタント層の座屈現象に対する脂質組成の影響:分子動力学解析

岸上夏輝, Koshiyama Kenichiro

日本機械学会第32回バイオフロンティア講演会講演論文集, Jan 13, 2022, Japan Society of Mechanical Engineers
肺胞隔壁の発達に伴う肺胞内力学場変化の理解に向けた有限要素解析

Kusano Shin, Koshiyama Kenichiro

日本機械学会第32回バイオフロンティア講演会講演論文集, Jan 12, 2022, Japan Society of Mechanical Engineers
単軸引張試験と有限要素解析を用いた肺組織力学モデルの同定

木下敦斗, Koshiyama Kenichiro

日本機械学会第32回バイオフロンティア講演会講演論文集, Jan 12, 2022, Japan Society of Mechanical Engineers
Mathematical modeling of pulmonary acinus structure: analysis of pathway structure in conical outer shapes

Atsuki Ishikawa, Koshiyama Kenichiro

The 11th Asian-Pacific Conference on Biomechanics Abstract book, Dec 2, 2021
Molecular dynamics simulations of a mechanosensitive channel under tension: Effects of hydrophobic molecules on the structural changes of the channel-embedded lipid bilayer

Yusuke Tsutsumi, Koshiyama Kenichiro

The 11th Asian-Pacific Conference on Biomechanics Abstract book, Dec 2, 2021
生体医工学技術開発:非平衡脂質分子動力学シミュレーションからの示唆

Koshiyama Kenichiro

第6回ソフトマター工学分科会講演会講演論文集, Nov 12, 2021 Invited
せん断流れにより誘起されるリン脂質二重膜の張力:分子動力学シミュレーション

重松大樹, Koshiyama Kenichiro

日本流体力学会年会2021 講演論文集, Sep 22, 2021
円錐状肺細葉構造の数理モデル:肺細葉気道分布の解析

Ishikawa Atsuki, Koshiyama Kenichiro

日本機械学会第34回計算力学講演会講演論文集, Sep 21, 2021, Japan Society of Mechanical Engineers
Molecular Dynamics Simulations of Structural Changes of Lipid Bilayers Under High Pressure

Koshiyama Kenichiro

日本機械学会2021年度年次大会講演論文集, Sep 7, 2021

Research Projects

小児肺微小構造の成熟と力学場の関係

科学研究費助成事業, 基盤研究(B), 日本学術振興会, Apr, 2023 - Mar, 2027

越山顕一朗, 世良俊博, 伊井仁志
肺リモデリングメカニズムの解明に向けた気道末梢部位の力学環境と細胞力学応答解析

科学研究費助成事業基盤研究(B), 基盤研究(B), 日本学術振興会, Apr, 2019 - Mar, 2023

世良俊博, 田中学, 工藤奨, 越山顕一朗
Generation of Biomechanics for Infant Lung Acinus

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2018 - Mar, 2021

KOSHIYAMA Kenichiro
Therapeutic system for metastatic lymph nodes at early stages

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A), Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020

Kodama Tetsuya
Next-generation ultrasound contrast agent development platform based on elucidating the physical phenomenon of lipid coated nanobubbles

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Koshiyama Kenichiro, SHIGEMATSU DAIKI, KURUMATANI RYOTARO, TANEO MASAKI
What is the reason to form the thrombi with different internal structures and mechanical characteristics?

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Wada Shigeo, HIRAKATA Hideo, SUGITA Naoko
Multiscale mechanical modeling and analysis of the lung for better understanding of the pathological remodeling mechanism

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A), Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2016

WADA SHIGEO, KOSHIYAMA KENICHIRO, II SATOSHI, SERA TOSHIHIRO, MIYAZAKI HIROSHI
Molecular mechanisms about ultrasound neuromodulation

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (A), Grant-in-Aid for Young Scientists (A), Japan Society for the Promotion of Science, Nov, 2011 - Mar, 2014

KOSHIYAMA KENICHIRO
Three dimensional measurements of collagen structure in a vascular tissue subject to abnormal mechanical remodeling

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, 2011 - 2012

WADA Shigeo
Towards the establishment of hemolysis simulator by a multi-scale analysis and experimental observations of damages on a red blood cell membrane and

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2010 - 2012

NAKAMURA Masanori, WADA Shigeo, MIYAZAKI Hiroshi, KOSHIYAMA Kenichiro
Molecular Mechanisms about Changes of Cell Membranes Functions : Induced by Shear Forces

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2008 - 2010

KOSHIYAMA Kenichiro
Computational studies on the development of intracranial aneurysms considering arterial wall remodeling induced by hemodynamics factors

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2005 - 2008

WADA Shigeo, TSUBOTA Kenichi, TAKAHASHI Akira, YAMAGUCHI Takami, MIYAZAKI Hiroshi, NAKAMURA Masanori, KOSHIYAMA Kenichiro

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