Katsuhiko Mikoshiba

Profile Information

Affiliation: -
: 特任教授, 理学部, 東邦大学

Degree: 医学博士(慶應義塾大学)

Researcher number: 30051840
J-GLOBAL ID: 200901087693746627
researchmap Member ID: 1000010890

External link: http://hr.shanghaitech.edu.cn/2019/0613/c4785a43104/page.htm

Research Interests

Research Areas

Research History

1973 - 1974

Instructor, Department of Physiology, Keio University School of Medicine
1974 - 1982

Assistant Professor, Department of Physiology, Keio University School of Medicine
1976 - 1977

Research Associate, Pasteur Institute, Paris, France (c/o Dr. Jean-Pierre Changeux)
1982 - 1985

Associate Professor, Department of Physiology, Keio University School of Medicine
1985 - 1992

Professor, Division of Regulation of Macromolecular Function, Institute for Protein Research, Osaka University
1986 - 1991

Professor, Division of Behavior and Neurobiology, National Institute for Basic Biology
1991 - 1992

Professor, Department of Molecular Neurobiology, The Institute of Medical Science, The University of Tokyo
1992 - 1997

Chief Scientist, Molecular Neurobiology Laboratory, The Institute of Physical and Chemical Research (RIKEN), Tsukuba Life Science Center
1992 - 2007

Professor, Department of Molecular Neurobiology, The Institute of Medical Science, The University of Tokyo
1995 - 2000

Project Leader, Mikoshiba Calciosignal Net Project, Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Corporation (JST)
1997 - 2009

Team Leader, Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN
2001 - 2005

Research Director, The International Cooperative Research Project (calcium oscillation project) Japan Science and Technology Agency (JST)
2006 - 2011

Research Director, Solution Oriented Research for Science and Technology (calcium oscillation project) Japan Science and Technology Agency (JST)
2008 - 2009

RIKEN
2009 - 2018

Senior Team Leader, Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN
2018 - 2019

Senior Team Leader, Laboratory for Developmental Neurobiology, Center for Brain Science, RIKEN
2019 - Present

Professor, SIAIS (Shanghai Institute for Advanced Immunochemical Studies), ShanghaiTech
2019 - Present

Professor, Toho University Faculty of Science

Papers

769

Synaptic plasticity in hippocampal CA1 neurons of mice lacking inositol-1,4,5-trisphosphate receptor-binding protein released with IP3 (IRBIT).

Jun-Ichi Goto, Satoshi Fujii, Hiroki Fujiwara, Katsuhiko Mikoshiba, Yoshihiko Yamazaki

Learning & memory (Cold Spring Harbor, N.Y.), 29(4) 110-119, Apr, 2022
Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis

Rosa N, Ivanova H, Wagner LE, Kale J, La Rovere R, Welkenhuyzen K, Louros N, Karamanou S, Shabardina V, Lemmens I …

Cell Death Differ, 29(4) 788-805, Apr, 2022 Peer-reviewed
A non-canonical role for pyruvate kinase M2 as a functional modulator of Ca2+ signalling through IP3 receptors

Lavik AR, McColl KS, Lemos FO, Kerkhofs M, Zhong F, Harr M, Schlatzer D, Hamada K, Mikoshiba K, Crea F …

Biochim Biophys Acta Mol Cell Res, 1869(4) 119206, Apr, 2022 Peer-reviewed
Reactive astrocyte-driven epileptogenesis is induced by microglia initially activated following status epilepticus

Fumikazu Sano, Eiji Shigetomi, Youichi Shinozaki, Haruka Tsuzukiyama, Kozo Saito, Katsuhiko Mikoshiba, Hiroshi Horiuchi, Dennis Lawrence Cheung, Junichi Nabekura, Kanji Sugita …

JCI Insight, Apr 8, 2021
Both IRBIT and long-IRBIT bind to and coordinately regulate Cl-/HCO3- exchanger AE2 activity through modulating the lysosomal degradation of AE2.

Ryo Itoh, Naoya Hatano, Momoko Murakami, Kosuke Mitsumori, Satoko Kawasaki, Tomoka Wakagi, Yoshino Kanzaki, Hiroyuki Kojima, Katsuhiro Kawaai, Katsuhiko Mikoshiba …

Scientific reports, 11(1) 5990-5990, Mar 16, 2021
Astrocytic IP3Rs: Beyond IP3R2.

Mark W Sherwood, Misa Arizono, Aude Panatier, Katsuhiko Mikoshiba, Stéphane H R Oliet

Frontiers in cellular neuroscience, 15 695817-695817, 2021
Inhibitory Synaptic Transmission Tuned by Ca²⁺ and Glutamate Through the Control of GABA_AR Lateral Diffusion Dynamics

Bannai H, Niwa F, Sakuragi S, Mikoshiba K

Dev. Growth Differ., Apr 23, 2020 Peer-reviewed
Synaptic Function and Neuropathological Disease Revealed by Quantum Dot-Single-Particle Tracking

Hiroko Bannai, Takafumi Inoue, Matsumi Hirose, Fumihiro Niwa, Katsuhiko Mikoshiba

Neuromethods, 131-155, 2020 Peer-reviewed
Depotentiation depends on IP3 receptor activation sustained by synaptic inputs after LTP induction

Fujii, S, Yamazaki Y, Goto, J.-I, Fujiwara, H, Mikoshiba K

Learning & Memory, 27(2) 52-66, Jan, 2020 Peer-reviewed
An ultra-stable cytoplasmic antibody engineered for in vivo applications.

Kabayama, H, Takeuchi, M, Tokushige, N, Muramatsu, S. I, Kabayama, M, Fukuda, M, Yamada, Y, Mikoshiba, K

Nat. Commun., 11(1) 336-336, Jan, 2020 Peer-reviewed
Histamine H1 receptor on astrocytes and neurons controls distinct aspects of mouse behaviour.

Anikó Kárpáti, Takeo Yoshikawa, Fumito Naganuma, Takuro Matsuzawa, Haruna Kitano, Yo Yamada, Mariko Yokoyama, Akira Futatsugi, Katsuhiko Mikoshiba, Kazuhiko Yanai

Scientific reports, 9(1) 16451-16451, Nov 11, 2019 Peer-reviewed
IP₃ Receptor Plasticity Underlying Diverse Functions.

Hamada K, Mikoshiba K

Annual review of physiology, Nov, 2019 Peer-reviewed
Inositol 1,4,5-trisphosphate receptor 2 as a novel marker of vasculature to delineate processes of cardiopulmonary development.

Ishizaki-Asami R, Uchida K, Tsuchihashi T, Shibata A, Kodo K, Emoto K, Mikoshiba K, Takahashi T, Yamagishi H

Developmental biology, 458(2) 237-245, Nov, 2019 Peer-reviewed
Bcl-2 and IP₃ compete for the ligand-binding domain of IP₃Rs modulating Ca²⁺ signaling output.

Ivanova H, Wagner LE, Tanimura A, Vandermarliere E, Luyten T, Welkenhuyzen K, Alzayady KJ, Wang L, Hamada K, Mikoshiba K …

Cellular and molecular life sciences : CMLS, 76(19) 3843-3859, Oct, 2019 Peer-reviewed
Ouabain-regulated phosphoproteome reveals molecular mechanisms for Na⁺, K⁺-ATPase control of cell adhesion, proliferation, and survival.

Panizza E, Zhang L, Fontana JM, Hamada K, Svensson D, Akkuratov EE, Scott L, Mikoshiba K, Brismar H, Lehtiö J …

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(9) 10193-10206, Sep, 2019 Peer-reviewed
IP₃ receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer.

Bartok A, Weaver D, Golenár T, Nichtova Z, Katona M, Bánsághi S, Alzayady KJ, Thomas VK, Ando H, Mikoshiba K …

Nature communications, 10(1) 3726, Aug, 2019 Peer-reviewed
Type 2 inositol 1,4,5-trisphosphate receptor inhibits the progression of pulmonary arterial hypertension via calcium signaling and apoptosis.

Shibata A, Uchida K, Kodo K, Miyauchi T, Mikoshiba K, Takahashi T, Yamagishi H

Heart and vessels, 34(4) 724-734, Apr, 2019 Peer-reviewed
Constitutive IP₃ signaling underlies the sensitivity of B-cell cancers to the Bcl-2/IP₃ receptor disruptor BIRD-2.

Bittremieux M, La Rovere RM, Akl H, Martines C, Welkenhuyzen K, Dubron K, Baes M, Janssens A, Vandenberghe P, Laurenti L …

Cell death and differentiation, 26(3) 531-547, Mar, 2019 Peer-reviewed
A novel multi lines analysis tool of Ca²⁺ dynamics reveals the nonuniformity of Ca²⁺ propagation.

Miyamoto A, Mikoshiba K

Cell calcium, 78 76-80, Mar, 2019 Peer-reviewed
Dual-FRET imaging of IP₃ and Ca²⁺ revealed Ca²⁺-induced IP₃ production maintains long lasting Ca²⁺ oscillations in fertilized mouse eggs.

Matsu-Ura T, Shirakawa H, Suzuki KGN, Miyamoto A, Sugiura K, Michikawa T, Kusumi A, Mikoshiba K

Scientific reports, 9(1) 4829, Mar, 2019 Peer-reviewed

Misc.

203

Type 3 Inositol 1,4,5-Trisphosphate Receptor is a Crucial Regulator of Calcium Dynamics Mediated by Endoplasmic Reticulum in HEK Cells.

Lili Yue, Liuqing Wang, Yangchun Du, Wei Zhang, Kozo Hamada, Yoshifumi Matsumoto, Xi Jin, Yandong Zhou, Katsuhiko Mikoshiba, Donald L Gill …

Cells, 9(2), Jan 22, 2020
IP₃受容体の結晶構造からひもとくアロステリック機構と疾病メカニズム

濱田耕造, 宮武秀行, 寺内明子, 御子柴克彦

日本生化学会大会(Web), 90th ROMBUNNO.2AW07‐1 (WEB ONLY), 2017
IRBITは脂肪細胞分化初期の細胞増殖を制御している

関口藍理, 浜田浩一, 佐藤聖子, 高橋透泰, 下田沙弥, 波多野直哉, 河合克宏, 御子柴克彦, 水谷顕洋

聖マリアンナ医科大学雑誌(Web), 44(3) 183 (WEB ONLY)-183, Nov, 2016
The cell- and tissue-specific transcription mechanism of the TATA-less syntaxin 1A gene (vol 30, pg 525, 2016)

Takahiro Nakayama, Katsuhiko Mikoshiba, Kimio Akagawa

FASEB JOURNAL, 30(5) 2064-2064, May, 2016
A Role of Inositol 1,4,5-trisphosphate Receptors to Inhibit the Progression of Pulmonary Arterial Hypertension

Akimichi Shibata, Keiko Uchida, Reina Ishizaki, Takatoshi Tsuchihashi, Jun Maeda, Katsuhiko Mikoshiba, Hiroyuki Yamagishi

CIRCULATION, 132, Nov, 2015
肺高血圧症の重症化を抑制するイノシトール三リン酸受容体の役割

柴田映道, 内田敬子, 石崎怜奈, 土橋隆俊, 前田潤, 御子柴克彦, 山岸敬幸

呼吸と循環, 63(8) S30-S30, Aug, 2015
Modulation of spatiotemporal calcium dynamics in single astrocytes by neuronal activity

Y. Dembitskaya, Y. -W. Wu, X. Tang, M. Arizono, H. Bannai, P. -Y. Shih, V. Kazantsev, M. Tanaka, S. Itohara, K. Mikoshiba …

JOURNAL OF NEUROCHEMISTRY, 134 103-103, Aug, 2015
細胞内カルシウム制御分子イノシトール三リン酸受容体は肺動脈性肺高血圧の重症化を抑制する

柴田映道, 内田敬子, 石崎怜奈, 土橋隆俊, 前田潤, 御子柴克彦, 山岸敬幸

日本小児肺循環研究会プログラム・抄録集, 21回 17-17, Jan, 2015
イノシトール三リン酸受容体(2型)の肺動脈発生マーカーとしての有用性

石崎怜奈, 内田敬子, 柴田映道, 土橋隆俊, 前田潤, 御子柴克彦, 山岸敬幸

日本小児肺循環研究会プログラム・抄録集, 21回 18-18, Jan, 2015
IRBITはphosphatidylinositol phosphate kinasesの活性中心と結合する

安東英明, 廣瀬松美, GAINCHE Laura, 河合克宏, BONNEAU Benjamin, 伊集院壮, 伊藤俊樹, 竹縄忠臣, 御子柴克彦

日本生化学会大会(Web), 88th, 2015
Probing the Functional Coupling Interface between STIM1 and Orai1

Xizhuo Wang, Eunan Hendron, Yandong Zhou, Jun-ichi Goto, Katsuhiko Mikoshiba, Yoshihiro Baba, Tomohiro Kurosaki, Youjun Wang, Donald L. Gill

BIOPHYSICAL JOURNAL, 108(2) 565A-565A, Jan, 2015
IRBIT: A regulator of ion channels and ion transporters

Hideaki Ando, Katsuhiro Kawaai, Katsuhiko Mikoshiba

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1843(10) 2195-2204, Oct, 2014
肺高血圧症の進展におけるイノシトール三リン酸受容体の役割

内田敬子, 柴田映道, 石崎怜奈, 土橋隆俊, 山岸敬幸, 御子柴克彦

日本小児肺循環研究会プログラム・抄録集, 20回 15-15, Feb, 2014
The regulation of the ER-mitochondria-Ca2+cross-talk by Bcl-2 and Bcl-XL: A new scenario for the development of selective tools in oncology?

Haidar Akl, Giovanni Monaco, Elke Decrock, Rita La Rovere, Kirsten Welkenhuyzen, Tomas Luyten, Santeri Kiviluoto, Tim Vervliet, Jordi Molgo, Ludwig Missiaen …

CANCER RESEARCH, 73, Oct, 2013
Syntaxin1A遺伝子の組織特異的発現制御機構

中山高宏, 御子柴克彦, 赤川公朗

日本生化学会大会(Web), 86th 3P-359 (WEB ONLY)-359, Sep, 2013
CEREBRAL CORTICAL BLOOD FLOW RESPONSE TO BRIEF BASAL FOREBRAIN STIMULATION

N. Takata, T. Nagai, K. Ozawa, K. Mikoshiba, H. Hirase

GLIA, 61 S190-S190, Jul, 2013
ASTROCYTIC CA(2+) SIGNALS AFFECT ON TRIPARTITE SYNAPSE STRUCTURE AND HIPPOCAMPUS-RELATED LEARNING AND MEMORY

M. Tanaka, P. -Y. Shih, H. Gomi, T. Yoshida, J. Nakai, R. Ando, T. Furuichi, K. Mikoshiba, A. Semyanov, S. Itohara

GLIA, 61 S119-S119, Jul, 2013
THE PRINCIPLE OF CA(2+) INTEGRATION IN SINGLE ASTROCYTES

Y. -W. Wu, X. Tang, M. Arizono, H. Bannai, P. -Y. Shih, M. Tanaka, S. Itohara, K. Mikoshiba, A. Semyanov

GLIA, 61 S113-S113, Jul, 2013
Activation of IP (3) receptors during preconditioning stimulations determines the direction of synaptic plasticity in hippocampal neurons

Jun-Ichi Goto, Yoshihiko Yamazaki, Makoto Sugita, Hiroki Fujiwara, Kenya Kaneko, Katsuhiko Mikoshiba, Satoshi Fujii

JOURNAL OF PHYSIOLOGICAL SCIENCES, 63 S125-S125, 2013
Receptor-selective diffusion barrier enhances sensitivity of astrocytic processes to metabotropic glutamate receptor stimulation

M. Arizono, H. Bannai, K. Nakamura, F. Niwa, M. Enomoto, T. Matsu-ura, A. Miyamoto, M. W. Sherwood, T. Nakamura, K. Mikoshiba

JOURNAL OF NEUROCHEMISTRY, 123 116-116, Oct, 2012

Research Projects

小胞体―細胞膜オルガネラ接合部のCa2+が神経可塑性、発生分化に及ぼす役割

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2020 - Mar, 2023

御子柴克彦
The elucidation of the mechanism of inner ear impairment via Inositol trisphosphate receptor induced by a stress load

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2019

Naganuma Hideaki
Role of IP3 Receptor in the Regulation of Synaptic Plasticity, Neuronal Function and Neuronal Development

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (S), Japan Society for the Promotion of Science, May, 2013 - Mar, 2018

Mikoshiba Katsuhiko
アポトーシス制御分子Ｂｃｌ－２とＩＰ３受容体による神経可塑性と神経突起伸展の制御

科学研究費助成事業, 特別研究員奨励費, 日本学術振興会, Apr, 2013 - Mar, 2016

御子柴克彦, BONNEAU BENJAMIN, BONNEAU Benjamin, BONNEAU B. R.
Study of IP_3 receptor/Ca^<2+> signaling in neural plasticity and brain development and differentiation

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (S), Japan Society for the Promotion of Science, 2008 - 2012

MIKOSHIBA Katsuhiko
高次神経機能発現に関わるIP3受容体/カルシウムチャネルの制御機構の解明

科学研究費助成事業, 基盤研究(A), 日本学術振興会, 2008 - 2008

御子柴克彦
Study of IP3 receptor/Ca^<2+> signaling in neural plasticity and brain development and differentiation

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (S), Japan Society for the Promotion of Science, 2003 - 2007

MIKOSHIBA Katsuhiko
Study for IP_3 - detecting system of IP_3 receptor

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, 2001 - 2002

MIKOSHIBA Katsuhiko
Role of IP_3 receptor/ Ca^<2+> signaling for synaptic plasticity and development and differentiation of brain

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, 2001 - 2002

MIKOSHIBA Katsuhiko
Sudare Collimator Imaging Using Synchrotron Radiation

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2000 - 2001

SUGIMURA Kazuro, NEGORO Hitoshi, YAMASAKI Katsuhito, MAEDA Sakan, MIKOSHIBA Katsuhiko, SHIKATA Yoshihiro
伝達物質放出の制御によるシナプス伝達の可塑性

科学研究費助成事業, 基盤研究(C), 日本学術振興会, 2000 - 2000

阿部輝雄, 東田陽博, 御子柴克彦, 高橋正身, 五十嵐道弘, 八尾寛
Role of IP_3 receptor/Ca^<2+> signaling in neural plasticity and brain development

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A)., Japan Society for the Promotion of Science, 1999 - 2000

MIKOSHIBA Katsuhiko
Analysis of the molecular dynamics of intracellular signal transduction by chromophore, assisted inactivatid

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 1998 - 1999

MIKOSHIBA Katsuhiko
Molecular Mechanism of corticohistoqenesis of the brain

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B)., Japan Society for the Promotion of Science, 1998 - 1999

MIKOSHIBA Katsuhiko, OGAWA Masaharu
Studies on the molecular mechanism of calcium signaling and the role of IP3 receptor in development and differentiation

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, 1997 - 1998

MIKOSHIBA Katsuhiko, MICHIKAWA Takayuki, FURUICHI Teiichi
神経活動による遺伝子発現とその制御機構

科学研究費助成事業, 特定領域研究(A), 日本学術振興会, 1995 - 1998

小幡邦彦, 三木直正, 岡本仁, 古市貞一, 白尾智明, 池中一裕, SAFFEN David, 御子柴克彦
脳研究における生物物理学的アプローチの探索

科学研究費助成事業, 基盤研究(C), 日本学術振興会, 1997 - 1997

葛西道生, 御子柴克彦, 曽我部正博, 桐野豊, 村上富士夫, 柳田敏雄
Studies on insect instinct behavior, selection of larval food.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, 1996 - 1997

MARUYAMA Kosaku, ARIKAWA Kentaro, ENDO Katsuhiko, MIKOSHIBA Katsuhiko, KANZAKI Ryohei, NISHIDA Ritsuo
Regulatory mechanism of neurotransmitter release

Grants-in-Aid for Scientific Research, Grant-in-Aid for international Scientific Research, Japan Society for the Promotion of Science, 1996 - 1997

MIKOSHIBA Matsuhiko, MICHIKAWA Takayuki, INOUE Takafumi, FURUICHI Teiichi, RODOLFO R.Linas
Cellular dynamics of functional molecules and second messengers during synaptic transmission

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, 1995 - 1996

MIKOSHIBA Katsuhiko, MICHIKAWA Takayuki, FURYICHI Teiichi

Industrial Property Rights

特開2018-191565 大腸菌のペリプラズムを利用した、蛍光タンパク質または化合物のスクリーニング方法、並びにこれらの方法に用いることができる大腸菌およびベクター

御子柴克彦, 宮本章歳
WO2018-034298 カルシウムインジケーターを有する遺伝子改変トリパノソーマ・クルージおよび抗トリパノソーマ薬のスクリーニングのためのその応用

御子柴克彦, 奈良武司, 橋本宗明
特許第6245570号トリパノソーマ関連疾患治療薬、トリパノソーマ原虫の殺虫方法およびその利用

御子柴克彦, 奈良武司, 橋本宗明
特開2015-074629 トリパノソーマ関連疾患治療薬、トリパノソーマ原虫の殺虫方法およびその利用

御子柴克彦, 奈良武司, 橋本宗明
特許第5604948号トランスグルタミナーゼによるIP3レセプターの修飾

御子柴克彦, 濱田耕造, 寺内明子
特許第5606913号蛋白質架橋阻害剤

御子柴克彦, 貫名信行, 尾崎庄一郎, 濱田耕造, 後藤純一, 鈴木商信, 戎井悦子, 寺内明子
特許第5360635号新規ビスホウ素化合物

御子柴克彦, 尾崎庄一郎, 鈴木商信, 中村健
特許第5246715号蛋白質架橋阻害剤およびその用途

御子柴克彦, 濱田耕造, 寺内明子, 尾崎庄一郎, 後藤純一, 戎井悦子, 鈴木商信
特許第5146944号 IP3受容体結合タンパク質による細胞内標的分子の制御

御子柴克彦, 安東英明, 水谷顕洋
WO2012-096384 小胞体カルシウムATPアーゼ動態指示薬及びその利用

御子柴克彦, 松浦徹, 佐藤嘉名与
WO2012-057294 マラリアの治療方法、マラリア原虫の殺虫方法、及びその利用

御子柴克彦, 榎本匡宏, 河津信一郎
特開2011-219417 トランスグルタミナーゼによるIP3レセプターの修飾

御子柴克彦, 濱田耕造, 寺内明子
特許第4808952号 IP3指示薬

御子柴克彦, 松浦徹, 道川貴章, 井上貴文
特開2010-195768 蛋白質架橋阻害剤およびその用途

御子柴克彦, 濱田耕造, 寺内明子, 尾崎庄一郎, 後藤純一, 戎井悦子, 鈴木商信
特許第4472534号細胞内Caイオンの機能制御

御子柴克彦, 廣田順二, 安東英明
WO2010-018837 蛋白質架橋阻害剤

御子柴克彦, 貫名信行, 尾崎庄一郎, 濱田耕造, 後藤純一, 鈴木商信, 戎井悦子, 寺内明子
特開2009-184988 新規ホウ素化合物及びそれを含む細胞内カルシウム濃度調節剤又は医薬組成物

御子柴克彦, 尾崎庄一郎, 戎井悦子
特許第4219648号新規IP3受容体結合タンパク質とIP3指示薬

御子柴克彦, 安東英明, 水谷顕洋, 松浦徹
WO2008-001944 自己抗体検出用試薬及び自己免疫疾患の診断キット

御子柴克彦
特開2007-284433 IP3受容体結合タンパク質による細胞内標的分子の制御

御子柴克彦, 安東英明, 水谷顕洋

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