2019年4月
Plasma exchange is highly effective for ANCA-associated vasculitis patients with rapidly progressive glomerulonephritis who have advanced to dialysis dependence: A single-center case series
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
- 巻
- 23
- 号
- 3:::SI
- 開始ページ
- 253
- 終了ページ
- 260
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1111/1744-9987.12830
- 出版者・発行元
- WILEY
Plasma exchange (PEX) can be an effective treatment in ANCA-associated vasculitis (AAV) with severe renal damage; however, it is still controversial. Among cases of newly diagnosed AAV with rapidly progressive glomerulonephritis (AAV-RPGN) at our department from 2008 onward, eleven patients who received PEX (7 cases for severe renal damage (R-PEX) and 4 cases for lung hemorrhage (L-PEX)) were retrospectively analyzed. All cases of R-PEX were dependent on hemodialysis at the beginning of PEX and all received 7 sessions of PEX (50 ml/kg or 1.3 plasma volume per exchange) within 2 weeks. All cases became dialysis-independent within 8 weeks, with 3- and 12-month cumulative renal survival rates of 100% and 80%, respectively. All cases of L-PEX retained their renal function. In rapidly developing, newly dialysis-dependent AAV-RPGN patients with normal renal function before disease onset, standard PEX can be expected to induce sufficient renal recovery to establish dialysis independence. This article is protected by copyright. All rights reserved.
- ID情報
-
- DOI : 10.1111/1744-9987.12830
- ISSN : 1744-9979
- PubMed ID : 31033151