2016年1月1日
Innovation of vascular engineering by mechanomedicine
Vascular Engineering: New Prospects of Vascular Medicine and Biology with a Multidiscipline Approach
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- 開始ページ
- 283
- 終了ページ
- 296
- 記述言語
- 英語
- 掲載種別
- 論文集(書籍)内論文
- DOI
- 10.1007/978-4-431-54801-0_15
- 出版者・発行元
- Springer Japan
This article describes how physical forces contribute to development, physiology, and pathology of vascular cells, focusing on endothelial cells and vascular smooth muscle cells. Based on these basic understandings of the mechanobiology, we discuss mechanomedicine, an application of the mechanobiology to medicine. Basic knowledge about cellular responses, such as cellular signal transduction pathway, gene expression, and cytoskeletal remodeling, to mechanical stimuli is important for understanding the pathology of vascular diseases including atherosclerosis. Introducing the knowledge of the vascular mechanobiology will not only contribute to the development of regenerative medicine using pluripotent stem cells but also provide a way to prevent diseases caused by thromboembolisms, such as myocardial and cerebral infarctions.
- ID情報
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- DOI : 10.1007/978-4-431-54801-0_15
- SCOPUS ID : 84978312649