2012年4月
Formation of axon-dendrite polarity in situ: initiation of axons from polarized and non-polarized cells.
Development, growth & differentiation
- ,
- ,
- 巻
- 54
- 号
- 3
- 開始ページ
- 398
- 終了ページ
- 407
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1111/j.1440-169X.2012.01344.x
- 出版者・発行元
- WILEY-BLACKWELL
Neurons are polarized cells that extend a single axon and several dendrites. Historically, how neurons establish their axon-dendrite polarity has been extensively studied using dissociated hippocampal cells in culture. Although such studies have identified the cellular and molecular mechanisms underlying axon-dendrite polarization, the conclusions have been limited to in vitro conditions. Recent progress using live imaging has enabled us to directly observe axon formation in situ, revealing distinct cellular mechanisms that regulate axon-dendrite polarization in vivo. In this review, we compare the cellular events during axon formation studied in various systems both in vivo and in vitro and discuss possible common mechanisms underlying the axon-dendrite polarization.
- リンク情報
- ID情報
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- DOI : 10.1111/j.1440-169X.2012.01344.x
- ISSN : 0012-1592
- PubMed ID : 22524609
- Web of Science ID : WOS:000303154100014