2010年7月6日
Preferential localization of IgG memory B cells adjacent to contracted germinal centers.
Proceedings of the National Academy of Sciences of the United States of America
- 巻
- 107
- 号
- 27
- 開始ページ
- 12192
- 終了ページ
- 7
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1073/pnas.1005443107
It has long been presumed that after leaving the germinal centers (GCs), memory B cells colonize the marginal zone or join the recirculating pool. Here we demonstrate the preferential localization of nitrophenol-chicken gamma-globulin-induced CD38(+)IgG1(+) memory B cells adjacent to contracted GCs in the spleen. The memory B cells in this region proliferated after secondary immunization, a response that was abolished by depletion of CD4(+) T cells. We also found that these IgG1(+) memory B cells could present antigen on their surface, and that this activity was required for their activation. These results implicate this peri-GC region as an important site for survival and reactivation of memory B cells.
- リンク情報
- ID情報
-
- DOI : 10.1073/pnas.1005443107
- PubMed ID : 20547847
- PubMed Central 記事ID : PMC2901464