論文

国際誌
2003年7月

Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice.

Cancer cell
  • Daisuke Ishida
  • Kohei Kometani
  • Hailin Yang
  • Kiyokazu Kakugawa
  • Kyoko Masuda
  • Kazuhiro Iwai
  • Misao Suzuki
  • Shigeyoshi Itohara
  • Tatsutoshi Nakahata
  • Hiroshi Hiai
  • Hiroshi Kawamoto
  • Masakazu Hattori
  • Nagahiro Minato
  • 全て表示

4
1
開始ページ
55
終了ページ
65
記述言語
英語
掲載種別
研究論文(学術雑誌)

SPA-1 (signal-induced proliferation-associated gene-1) is a principal Rap1 GTPase-activating protein in hematopoietic progenitors. SPA-1-deficient mice developed a spectrum of myeloid disorders that resembled human chronic myelogenous leukemia (CML) in chronic phase, CML in blast crisis, and myelodysplastic syndrome as well as anemia. Preleukemic SPA-1-deficient mice revealed selective expansion of marrow pluripotential hematopoietic progenitors, which showed abnormal Rap1GTP accumulation. Overexpression of an active form of Rap1 promoted the proliferation of normal hematopoietic progenitors, while SPA-1 overexpression markedly suppressed it. Furthermore, restoring SPA-1 gene in a SPA-1-deficient leukemic blast cell line resulted in the dissolution of Rap1GTP accumulation and concomitant loss of the leukemogenicity in vivo. These results unveiled a role of Rap1 in myeloproliferative stem cell disorders and a tumor suppressor function of SPA-1.

リンク情報
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/12892713
ID情報
  • ISSN : 1535-6108
  • PubMed ID : 12892713

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