論文

査読有り 国際誌
2019年

Assessment of Cognitive and Motor Skills in Parkinson's Disease by a Robotic Object Hitting Game.

Frontiers in neurology
  • Winnugroho Wiratman
  • ,
  • Shunsuke Kobayashi
  • ,
  • Fang-Yu Chang
  • ,
  • Kohei Asano
  • ,
  • Yoshikazu Ugawa

10
開始ページ
19
終了ページ
19
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3389/fneur.2019.00019

Parkinson's disease (PD) patients experience various symptoms including extrapyramidal motor disturbances and cognitive impairments, which cause difficulties in daily life. However, PD patients have rarely been studied under realistic task situations that require high-level interaction of cognitive and motor skills. The aim of this study was to investigate the contribution of cognitive and motor factors to the performance of PD patients under high cognitive and kinematic loads. Twenty-six PD patients and 14 control subjects participated in the study. The PD patients performed a task involving hitting targets and avoiding distractors in levodopa On and Off states. A robotic manipulandum device recorded the numbers of target and distractor hits and hand kinematics, including movement area and speed. Performance on standard cognitive batteries and the Movement Disorder Society - Unified Parkinson's Disease Rating Scale motor scores were examined. The results indicated that the PD patients hit significantly fewer targets and more distractors than did the controls (p < 0.05). In PD patients, the average hand speed was slower and the area of hand movement was smaller than those of the control subjects (p < 0.001). Levodopa significantly increased the average hand speed and movement area (p < 0.01), but levodopa had an insignificant effect on the number of correct targets hit and erroneous distractor hits. The scores of cognitive batteries predicted the performance with regard to both targets hit and distractor avoidance. Our results were indicative of a dynamic interaction between cognitive and kinematic skills while the PD patients performed a virtual reality game. Single-dose levodopa enhanced kinematic capacity, and the global intelligence level predicted game performance.

リンク情報
DOI
https://doi.org/10.3389/fneur.2019.00019
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30745892
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360146
ID情報
  • DOI : 10.3389/fneur.2019.00019
  • PubMed ID : 30745892
  • PubMed Central 記事ID : PMC6360146

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