論文

査読有り
2017年3月

Relationship between skeletal muscle mass and swallowing function in patients with Alzheimer's disease

GERIATRICS & GERONTOLOGY INTERNATIONAL
  • Daisuke Takagi
  • ,
  • Hirohiko Hirano
  • ,
  • Yutaka Watanabe
  • ,
  • Ayako Edahiro
  • ,
  • Yuki Ohara
  • ,
  • Hideyo Yoshida
  • ,
  • Hunkyung Kim
  • ,
  • Kohji Murakami
  • ,
  • Shouji Hironaka

17
3
開始ページ
402
終了ページ
409
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/ggi.12728
出版者・発行元
WILEY

Aim: The present study verified the hypothesis that decreased skeletal muscle in older adults with Alzheimer's disease is related to Alzheimer's disease progression and decreased oral or swallowing function.
Methods: We investigated 232 patients with Alzheimer's disease (31 men, 201 women, average age 85.4+/-5.9 years) in two regions in Japan. The patients provided basic information (sex and age), and were assessed for skeletal muscle index, dementia severity (clinical dementia rating), activities of daily living, nutritional status, oral status and swallowing function.
Results: Stratification by clinical dementia rating was as follows: clinical dementia rating 0.5: 21 patients (9.0%), clinical dementia rating 1: 85 patients (36.6%), clinical dementia rating 2: 88 patients (37.9%) and clinical dementia rating 3: 38 patients (16.3%). Alzheimer's disease severity was significantly related to skeletalmuscle index. Logistic regression analysis showed that clinical dementia rating 3 (odds ratio 11.68, 95% confidence interval 4.52-30.20), body mass index<18.5 (odds ratio 3.18, 95% confidence interval 1.27-8.00), calf circumference <30.5cm (odds ratio 9.33, 95% confidence interval 2.01-43.27) and poor swallowing function (odds ratio 4.93, 95% confidence interval 1.10-22.04) had a significant effect on decreased skeletal muscle index.
Conclusions: Therefore, decreased skeletal muscle mass in patients with Alzheimer's disease requires strategies to manage swallowing dysfunction.

リンク情報
DOI
https://doi.org/10.1111/ggi.12728
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27153367
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000399446800005&DestApp=WOS_CPL
ID情報
  • DOI : 10.1111/ggi.12728
  • ISSN : 1444-1586
  • eISSN : 1447-0594
  • PubMed ID : 27153367
  • Web of Science ID : WOS:000399446800005

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