MISC

2008年12月

Dynamin 2 Cooperates with Amphiphysin 1 in Phagocytosis in Sertoli Cells

ACTA MEDICA OKAYAMA
  • Akira Nakanishi
  • ,
  • Tadashi Abe
  • ,
  • Masami Watanabe
  • ,
  • Kohji Takei
  • ,
  • Hiroshi Yamada

62
6
開始ページ
385
終了ページ
391
記述言語
英語
掲載種別
DOI
10.18926/AMO/30954
出版者・発行元
OKAYAMA UNIV MED SCHOOL

Testicular Sertoli cells highly express dynamin 2 and amphiphysin 1. Here we demonstrate that dynamin 2 is implicated in phosphatidylserine (PS)-dependent phagocytosis in Sertoli cells. Immunofluorescence and dual-live imaging revealed that dynamin 2 and amphiphysin 1 accumulate simultaneously at ruffles. These proteins are specifically bound in vitro. Over-expression of dominant negative dynamin 2 (K44A) inhibits liposome-uptake and leads to the mis-localization of amphiphysin 1. Thus, the cooperative function of dynamin 2 and amphiphysin 1 in PS-dependent phagocytosis is strongly suggested.


リンク情報
DOI
https://doi.org/10.18926/AMO/30954
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000262025000005&DestApp=WOS_CPL
ID情報
  • DOI : 10.18926/AMO/30954
  • ISSN : 0386-300X
  • Web of Science ID : WOS:000262025000005

エクスポート
BibTeX RIS