2008年12月
Dynamin 2 Cooperates with Amphiphysin 1 in Phagocytosis in Sertoli Cells
ACTA MEDICA OKAYAMA
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- 巻
- 62
- 号
- 6
- 開始ページ
- 385
- 終了ページ
- 391
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.18926/AMO/30954
- 出版者・発行元
- OKAYAMA UNIV MED SCHOOL
Testicular Sertoli cells highly express dynamin 2 and amphiphysin 1. Here we demonstrate that dynamin 2 is implicated in phosphatidylserine (PS)-dependent phagocytosis in Sertoli cells. Immunofluorescence and dual-live imaging revealed that dynamin 2 and amphiphysin 1 accumulate simultaneously at ruffles. These proteins are specifically bound in vitro. Over-expression of dominant negative dynamin 2 (K44A) inhibits liposome-uptake and leads to the mis-localization of amphiphysin 1. Thus, the cooperative function of dynamin 2 and amphiphysin 1 in PS-dependent phagocytosis is strongly suggested.
- リンク情報
- ID情報
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- DOI : 10.18926/AMO/30954
- ISSN : 0386-300X
- Web of Science ID : WOS:000262025000005