2016年5月
Antiobesity Action of ACAM by Modulating the Dynamics of Cell Adhesion and Actin Polymerization in Adipocytes
DIABETES
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- 巻
- 65
- 号
- 5
- 開始ページ
- 1255
- 終了ページ
- 1267
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.2337/db15-1304
- 出版者・発行元
- AMER DIABETES ASSOC
Coxsackie virus and adenovirus receptor-like membrane protein (CLMP) was identified as the tight junction-associated transmembrane protein of epithelial cells with homophilic binding activities. CLMP is also recognized as adipocyte adhesion molecule (ACAM), and it is upregulated in mature adipocytes in rodents and humans with obesity. Here, we present that aP2 promoter-driven ACAM transgenic mice are protected from obesity and diabetes with the prominent reduction of adipose tissue mass and smaller size of adipocytes. ACAM is abundantly expressed on plasma membrane of mature adipocytes and associated with formation of phalloidin-positive polymerized form of cortical actin (F-actin). By electron microscopy, the structure of zonula adherens with an intercellular space of approximate to 10-20 nm was observed with strict parallelism of the adjoining cell membranes over distances of 1-20 m, where ACAM and -actin are abundantly expressed. The formation of zonula adherens may increase the mechanical strength, inhibit the adipocyte hypertrophy, and improve the insulin sensitivity.
- リンク情報
- ID情報
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- DOI : 10.2337/db15-1304
- ISSN : 0012-1797
- eISSN : 1939-327X
- Web of Science ID : WOS:000375028000016