MISC

2005年3月

Regulatory mechanisms of dynamin-dependent endocytosis

JOURNAL OF BIOCHEMISTRY
  • K Takei
  • ,
  • Y Yoshida
  • ,
  • H Yamada

137
3
開始ページ
243
終了ページ
247
記述言語
英語
掲載種別
書評論文,書評,文献紹介等
DOI
10.1093/jb/mvi052
出版者・発行元
JAPANESE BIOCHEMICAL SOC

Extensive studies on endocytosis in the last decade have resulted in identification of several key molecules that function in clathrin- and dynamin-dependent endocytosis. Most endocytic molecules contain multiple binding motifs that mediate protein-protein or protein-lipid interactions, which must be modulated spatially and temporally during endocytosis. Regulation of these interactions is the molecular basis of regulatory mechanisms involved in endocytosis. This review first describes current models of the mechanism of dynamin-dependent fission, then introduces several mechanisms that modulate dynamin GTPase activity and dynamin-dependent vesicle formation. Such mechanisms include regulation by inositol phospholipids, especially phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P-2], and their metabolism. It concludes by describing the regulation of dynamin 1 by its binding partner, amphiphysin 1, and regulation by cyclin-dependent kinase 5 (Cdk5)-dependent phosphorylation of dynamin 1 and amphiphysin 1. These mechanisms help endocytic molecules to function properly, and cooperatively regulate dynamin-dependent endocytosis.


リンク情報
DOI
https://doi.org/10.1093/jb/mvi052
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000228836400001&DestApp=WOS_CPL
ID情報
  • DOI : 10.1093/jb/mvi052
  • ISSN : 0021-924X
  • Web of Science ID : WOS:000228836400001

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