Kouichi Hashimoto

Profile Information

Affiliation: Hiroshima University

Degree: PhD

J-GLOBAL ID: 201101077070753463
researchmap Member ID: B000002371

External link

Research Areas

Life sciences / Neuroscience - general /

Research History

Apr, 2012 - Present

Professor, Department of Neurophysiology, Graduate School of Biomedical and Health Sciences, Hiroshima University
Jul, 2010

教授, 広島大学医歯薬学総合研究科
Apr, 2008 - Jun, 2010

准教授, 東京大学医学系研究科
2005 - 2006

助手, 大阪大学医学系研究科
2006

助手, 大阪大学医学(系)研究科(研究院)
2002 - 2005

助手, 金沢大学医学(系)研究科(研究院)
2004

助手, 金沢大学医学系研究科
2001 - 2003

助手, 金沢大学医学系研究科・大学院
1998 - 2001

Kanazawa University
2001

助手, 金沢大学医学系研究科

Papers

The indirect cortico–pontine pathway relays perioral sensory signals to the cerebellum via the mesodiencephalic junction

Reika Kubo, Takayuki Yoshida, Kenji Yamaoka, Kouichi Hashimoto

iScience, 107301-107301, Jul, 2023
PTPδ is a presynaptic organizer for the formation and maintenance of climbing fiber to Purkinje cell synapses in the developing cerebellum

Yuto Okuno, Kazuto Sakoori, Kyoko Matsuyama, Miwako Yamasaki, Masahiko Watanabe, Kouichi Hashimoto, Takaki Watanabe, Masanobu Kano

Frontiers in Molecular Neuroscience, 16, Jun 22, 2023
Cholinergic regulation of object recognition memory

Kana Okada, Kouichi Hashimoto, Kazuto Kobayashi

Frontiers in Behavioral Neuroscience, 16 996089, Sep 29, 2022 Peer-reviewed
High-mobility group box 1-mediated hippocampal microglial activation induces cognitive impairment in mice with neuropathic pain

Kazue Hisaoka-Nakashima, Kazuto Ohata, Natsuki Yoshimoto, Shintarou Tokuda, Nanako Yoshii, Yoki Nakamura, Dengli Wang, Keyue Liu, Hidenori Wake, Takayuki Yoshida …

EXPERIMENTAL NEUROLOGY, 355, Sep, 2022
Different cholinergic cell groups in the basal forebrain regulate social interaction and social recognition memory.

Kana Okada, Kayo Nishizawa, Tomoko Kobayashi, Shogo Sakata, Kouichi Hashimoto, Kazuto Kobayashi

Scientific reports, 11(1) 13589-13589, Jun 30, 2021
Spike firing attenuation of serotonin neurons in learned helplessness rats is reversed by ketamine.

Kouichi Hashimoto, Yosuke Yamawaki, Kenji Yamaoka, Takayuki Yoshida, Kana Okada, Wanqin Tan, Miwako Yamasaki, Yoshiko Matsumoto-Makidono, Reika Kubo, Hisako Nakayama …

Brain communications, 3(4) fcab285, 2021
An Autism-Associated Neuroligin-3 Mutation Affects Developmental Synapse Elimination in the Cerebellum.

Esther Suk King Lai, Hisako Nakayama, Taisuke Miyazaki, Takanobu Nakazawa, Katsuhiko Tabuchi, Kouichi Hashimoto, Masahiko Watanabe, Masanobu Kano

Frontiers in neural circuits, 15 676891-676891, 2021
Kv11 (ether-à-go-go-related gene) voltage-dependent K+ channels promote resonance and oscillation of subthreshold membrane potentials.

Toshinori Matsuoka, Miwako Yamasaki, Manabu Abe, Yukiko Matsuda, Hiroyuki Morino, Hideshi Kawakami, Kenji Sakimura, Masahiko Watanabe, Kouichi Hashimoto

The Journal of physiology, 599(2) 547-569, Jan, 2021
Zonisamide can ameliorate the voltage-dependence alteration of the T-type calcium channel CaV3.1 caused by a mutation responsible for spinocerebellar ataxia

Naoyuki Hara, Hiroyuki Morino, Yukiko Matsuda, Kenichi Satoh, Kouichi Hashimoto, Hirofumi Maruyama, Hideshi Kawakami

Molecular Brain, 13(1), Dec, 2020
Component of nicotine-induced intracellular calcium elevation mediated through α3- and α5-containing nicotinic acetylcholine receptors are regulated by cyclic AMP in SH-SY 5Y cells.

Tamayo Takahashi, Takayuki Yoshida, Kana Harada, Tatsuhiko Miyagi, Kouichi Hashimoto, Izumi Hide, Shigeru Tanaka, Masahiro Irifune, Norio Sakai

PloS one, 15(11) e0242349, 2020
The anatomical pathway from the mesodiencephalic junction to the inferior olive relays perioral sensory signals to the cerebellum in the mouse.

Kubo R, Aiba A, Hashimoto K

The Journal of physiology, 596(16) 3775-3791, Aug, 2018 Peer-reviewed
Microglia permit climbing fiber elimination by promoting GABAergic inhibition in the developing cerebellum.

Hisako Nakayama, Manabu Abe, Chie Morimoto, Tadatsune Iida, Shigeo Okabe, Kenji Sakimura, Kouichi Hashimoto

Nature communications, 9(1) 2830-2830, Jul 19, 2018 Peer-reviewed
Task-dependent function of striatal cholinergic interneurons in behavioural flexibility

Kana Okada, Kayo Nishizawa, Susumu Setogawa, Kouichi Hashimoto, Kazuto Kobayashi

European Journal of Neuroscience, 47(10) 1174-1183, May 1, 2018 Peer-reviewed
Glutamate transporter GLAST controls synaptic wrapping by Bergmann glia and ensures proper wiring of Purkinje cells

Taisuke Miyazaki, Miwako Yamasaki, Kouichi Hashimoto, Kazuhisa Kohda, Michisuke Yuzaki, Keiko Shimamoto, Kohichi Tanaka, Masanobu Kano, Masahiko Watanabe

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 114(28) 7438-7443, Jul, 2017 Peer-reviewed
Serotonin rebalances cortical tuning and behavior linked to autism symptoms in 15q11-13 CNV mice

Nobuhiro Nakai, Masatoshi Nagano, Fumihito Saitow, Yasuhito Watanabe, Yoshinobu Kawamura, Akiko Kawamoto, Kota Tamada, Hiroshi Mizuma, Hirotaka Onoe, Yasuyoshi Watanabe …

SCIENCE ADVANCES, 3(6) e1603001, Jun, 2017 Peer-reviewed
CAPS1 RNA Editing Promotes Dense Core Vesicle Exocytosis

Kotaro Miyake, Toshio Ohta, Hisako Nakayama, Nobutaka Doe, Yuri Terao, Eiji Oiki, Izumi Nagatomo, Yui Yamashita, Takaya Abe, Kazuko Nishikura …

CELL REPORTS, 17(8) 2004-2014, Nov, 2016 Peer-reviewed
The Metabotropic Glutamate Receptor Subtype 1 Mediates Experience-Dependent Maintenance of Mature Synaptic Connectivity in the Visual Thalamus

Madoka Narushima, Motokazu Uchigashima, Yuki Yagasaki, Takeshi Harada, Yasuyuki Nagumo, Naofumi Uesaka, Kouichi Hashimoto, Atsu Aiba, Masahiko Watanabe, Mariko Miyata …

NEURON, 91(5) 1097-1109, Sep, 2016 Peer-reviewed
Ionic Basis for Membrane Potential Resonance in Neurons of the Inferior Olive

Yoshiko Matsumoto-Makidono, Hisako Nakayama, Miwako Yamasaki, Taisuke Miyazaki, Kazuto Kobayashi, Masahiko Watanabe, Masanobu Kano, Kenji Sakimura, Kouichi Hashimoto

CELL REPORTS, 16(4) 994-1004, Jul, 2016 Peer-reviewed
Territories of heterologous inputs onto Purkinje cell dendrites are segregated by mGluR1-dependent parallel fiber synapse elimination

Ryoichi Ichikawa, Kouichi Hashimoto, Taisuke Miyazaki, Motokazu Uchigashima, Miwako Yamasaki, Atsu Aiba, Masanobu Kano, Masahiko Watanabe

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113(8) 2282-2287, Feb, 2016 Peer-reviewed
A CDC42EP4/septin-based perisynaptic glial scaffold facilitates glutamate clearance

Natsumi Ageta-Ishihara, Maya Yamazaki, Kohtarou Konno, Hisako Nakayama, Manabu Abe, Kenji Hashimoto, Tomoki Nishioka, Kozo Kaibuchi, Satoko Hattori, Tsuyoshi Miyakawa …

NATURE COMMUNICATIONS, 6 10090, Dec, 2015 Peer-reviewed

Misc.

Sensory signal transduction pathways from the perioral area to the cerebellar Purkinje cells

久保怜香, 橋本浩一

生体の科学, 72(1), 2021
マウスヒゲ触覚信号はarea parafascicularis prerubralisから下オリーブ核への経路を経て小脳に伝達される

久保怜香, 饗場篤, 橋本浩一

日本生理学雑誌(Web), 81(2), 2019
小脳回路発達と可塑性の最前線登上線維の発達過程におけるP/Q型電位依存性カルシウムチャネルの役割(Cellebellar circuitry: Cutting-edge of development and plasticity P/Q type voltage dependent Ca2+ channel is crucial for early postnatal development of climbing fiber to Purkinje cell synapse)

橋本浩一, 辻田実加, 喜多村和郎, 宮崎太輔, 山崎真弥, Shin Hee-Sup, 渡辺雅彦, 崎村建司, 狩野方伸

神経化学, 49(2-3) 461-461, Aug, 2010
発達期小脳における登上線維-プルキンエ細胞シナプスの機能分化

橋本浩一

日本生理学雜誌 = JOURNAL OF THE PHYSIOLOGICAL SOCIETY OF JAPAN, 65(11), Nov 1, 2003
遺伝子制御による選択的シナプス強化・除去機構の解明 (文部科学省S)

井ノ口馨, 橋本浩一, 真鍋俊也, 畑裕, 溝口明, 高橋正身, 狩野方伸

科学技術振興調整費試験研究実施計画, 2001, 2001
選択的シナプス強化、除去の分子機構

橋本浩一

神経化学, 39(4), Dec 25, 2000

Research Projects

Functional roles of the electrical activity in postnatal refinement of the neuronal circuitry

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2021

Hashimoto Kouichi
延髄下オリーブ核閾値下膜電位オシレーションの分子機構と機能的意義の解明

科学研究費助成事業, 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2018 - Mar, 2020

橋本浩一
Molecular mechanisms for the resonant property of neurons

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Jun, 2016 - Mar, 2018
Project to create international glial researcher network: mainly focusing on Japan-Germany research exchange

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Nov, 2015 - Mar, 2018

IKENAKA Kazuhiro, ITO Kei, UEKI Takatoshi, OHKI Kenichi, KATO Takahiro, KANEMARU Kazunori, SHIMIZU Takeshi, TAKEBAYASHI Hirohide, TANAKA Kenji, HASHIOTO Kohichi, YAMAZAKI Yoshihiko, INOUE Kazuhide, OKABE Shigeo, OZAKI Norio, KANBA Shigenobu, KIRA Junichi, KOHSAKA Shinichi, FUKUYAMA Hidenao, BANNAI Hiroko, NAKASHIMA Kinichi, IMAI Hiroo, MATSUI Ko, TACHIKAWA Masanori, KAKEGAWA Wataru
Basic research on elucidation of neurocircuit pathology of depression and its remodeling mechanism

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Yamawaki Shigeto, Okamoto Yasumasa, Okada Go, Hashimoto Koichi, Morioka Norimitsu, Yamawaki Yosuke
Regulation of synapse remodeling by glial assembly

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Jun, 2013 - Mar, 2018

Okabe Shigeo, WATANABE Masahiko
シナプスにおける逆行性シグナルが生後発達期の機能的神経回路形成に果たす役割の解明

科学研究費助成事業, 特別推進研究, 日本学術振興会, 2013 - 2018

狩野方伸, 崎村建司, 少作隆子, 橋本浩一
大脳皮質神経回路の生後発達に関わるメカニズムの解明

科学研究費助成事業, 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2013 - Mar, 2015

橋本浩一
Roles of maturation of presynaptic functions in the postnatal refinement of neuronal circuits.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2010 - 2012

HASHIMOTO Kouichi

Profile Information

Research Interests

Research Areas

Research History

Papers

Misc.

Research Projects

Menu

Coauthors