論文

国際誌
2018年3月4日

Spinal cord-specific deletion of the glutamate transporter GLT1 causes motor neuron death in mice.

Biochemical and biophysical research communications
  • Kaori Sugiyama
  • ,
  • Kohichi Tanaka

497
2
開始ページ
689
終了ページ
693
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.bbrc.2018.02.132

Amyotrophic lateral sclerosis (ALS) is a chronic neurodegenerative disorder characterized by the selective loss of motor neurons. The precise mechanisms that cause the selective death of motor neurons remain unclear, but a growing body of evidence suggests that glutamate-mediated excitotoxicity has been considered to play an important role in the mechanisms of motor neuron degeneration in ALS. Reductions in glutamate transporter GLT1 have been reported in animal models of ALS and the motor cortex and spinal cord of ALS patients. However, it remains unknown whether the reduction in GLT1 has a primary role in the induction of motor neuron degeneration in ALS. Here, we generated conditional knockout mice that lacked GLT1 specifically in the spinal cord by crossing floxed-GLT1 mice and Hoxb8-Cre mice. Hoxb8-Cre/GLT1flox/flox mice showed motor deficits and motor neuron loss. Thus, loss of the glial glutamate transporter GLT1 is sufficient to cause motor neuron death in mice.

リンク情報
DOI
https://doi.org/10.1016/j.bbrc.2018.02.132
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29458024
ID情報
  • DOI : 10.1016/j.bbrc.2018.02.132
  • PubMed ID : 29458024

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