2012年7月
Multiple patterns of spatiotemporal changes in layer-specific gene expression in the developing visual cortex of higher mammals
NEUROSCIENCE RESEARCH
- ,
- ,
- ,
- ,
- 巻
- 73
- 号
- 3
- 開始ページ
- 207
- 終了ページ
- 217
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.neures.2012.04.008
- 出版者・発行元
- ELSEVIER IRELAND LTD
The mammalian cerebral cortex, which is stratified into six layers, has functional domains that vertically span the six layers, thereby requiring tight interlaminar connectivity within a domain. The synaptic connections in individual layers are first broadly formed under predetermined programs and later reinforced between neurons which reside in the same functional domain via experience-dependent reorganization during the critical period. However, the molecular mechanisms that control these two processes within each layer are still unclear. Therefore, we performed a differential screen for candidates and found seven genes with layer-specific expression during postnatal development of cat visual cortex. APLP1, a transmembrane protein mediating synaptogenesis, started dual-layer expression in layers 2/3 and 5 before the critical period, suggesting that it might execute coarse synapse formation of these layers. STMN2 (SCG10), which promotes microtubule turnover, was unique, as it dramatically shifted its dual-layer distribution from layers 2/3 and 5 to the deeper layers 4 and 6 at the onset of the critical period; it lost this new expression pattern in the adult. Surprisingly, brief dark rearing disturbed the shift in its dual-layer distribution around the onset of the critical period. Thus, by accelerating structural remodeling, STMN2 (SCG10) might launch experience-dependent reorganization of particular layers. (C) 2012 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
- リンク情報
- ID情報
-
- DOI : 10.1016/j.neures.2012.04.008
- ISSN : 0168-0102
- eISSN : 1872-8111
- PubMed ID : 22575756
- Web of Science ID : WOS:000305660100004