2017年11月
Identification of an argpyrimidine-modified protein in human red blood cells from schizophrenic patients: A possible biomarker for, diseases involving carbonyl stress
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- 巻
- 493
- 号
- 1
- 開始ページ
- 573
- 終了ページ
- 577
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.bbrc.2017.08.150
- 出版者・発行元
- ACADEMIC PRESS INC ELSEVIER SCIENCE
Argpyrimidine (ARP) is an advanced glycation end product thought to be generated from a reaction between methylglyoxal and arginine residues in proteins. In this study, we observed marked accumulation of an approximately 56 kD protein, reactive to anti-ARP antibodies, in the red blood cells (RBCs) of some patients with refractory schizophrenia. This ARP-modified protein was purified from the blood of schizophrenic patients and identified as selenium binding protein 1 (SBP1) by LC-MS/MS. This is the first report of ARP-modified proteins accumulating in RBCs of patients with diseases involving carbonyl stress. We also observed high accumulation of ARP-modified SBP1 in the RBCs of patients with chronic kidney disease. Therefore, this modified protein may be a novel marker of carbonyl stress. (C) 2017 Elsevier Inc. All rights reserved.
- リンク情報
- ID情報
-
- DOI : 10.1016/j.bbrc.2017.08.150
- ISSN : 0006-291X
- eISSN : 1090-2104
- Web of Science ID : WOS:000413134200089