Kojima Hidenori

Profile Information

Affiliation: 循環器内科, 慶應義塾大学

J-GLOBAL ID: 201901020705976291
researchmap Member ID: B000372939

Research Interests

Research Areas

Life sciences / Cardiology /

Awards

2020

第45回日本心臓財団研究奨励, 日本心臓財団
Mar, 2019

Young Investigator's Award, 日本循環器学会

児島秀典

Papers

Soft Matrix Promotes Cardiac Reprogramming via Inhibition of YAP/TAZ and Suppression of Fibroblast Signatures.

Shota Kurotsu, Taketaro Sadahiro, Ryo Fujita, Hidenori Tani, Hiroyuki Yamakawa, Fumiya Tamura, Mari Isomi, Hidenori Kojima, Yu Yamada, Yuto Abe, Yoshiko Murakata, Tatsuya Akiyama, Naoto Muraoka, Ichiro Harada, Takeshi Suzuki, Keiichi Fukuda, Masaki Ieda

Stem cell reports, 15(3) 612-628, Sep 8, 2020
Tbx6 induces cardiomyocyte proliferation in postnatal and adult mouse hearts.

Haginiwa S, Sadahiro T, Kojima H, Isomi M, Tamura F, Kurotsu S, Tani H, Muraoka N, Miyake N, Miyake K, Fukuda K, Ieda M

Biochemical and biophysical research communications, 513(4) 1041-1047, Jun, 2019 Peer-reviewed
A tale of two sisters with hypertrophic cardiomyopathy and recurrent embolism: When is the optimal timing of the intervention for left atrial appendage?

Kimura M, Kohno T, Makino S, Okuda S, Nawata K, Yanagisawa R, Kojima H, Nishiyama T, Aizawa Y, Yuasa S, Murata M, Maekawa Y, Okamoto K, Shimizu H, Fukuda K

Heart & lung : the journal of critical care, 48(3) 198-200, May, 2019 Peer-reviewed
Role of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogramming.

Naoto Muraoka, Kaori Nara, Fumiya Tamura, Hidenori Kojima, Hiroyuki Yamakawa, Taketaro Sadahiro, Kazutaka Miyamoto, Mari Isomi, Sho Haginiwa, Hidenori Tani, Shota Kurotsu, Rina Osakabe, Satoru Torii, Shigeomi Shimizu, Hideyuki Okano, Yukihiko Sugimoto, Keiichi Fukuda, Masaki Ieda

Nature communications, 10(1) 674-674, Feb 20, 2019 Peer-reviewed
Tbx6 Induces Nascent Mesoderm from Pluripotent Stem Cells and Temporally Controls Cardiac versus Somite Lineage Diversification.

Taketaro Sadahiro, Mari Isomi, Naoto Muraoka, Hidenori Kojima, Sho Haginiwa, Shota Kurotsu, Fumiya Tamura, Hidenori Tani, Shugo Tohyama, Jun Fujita, Hiroyuki Miyoshi, Yoshifumi Kawamura, Naoki Goshima, Yuka W Iwasaki, Kensaku Murano, Kuniaki Saito, Mayumi Oda, Peter Andersen, Chulan Kwon, Hideki Uosaki, Hirofumi Nishizono, Keiichi Fukuda, Masaki Ieda

Cell stem cell, 23(3) 382-395, Sep 6, 2018 Peer-reviewed
Tbx6 Induces Nascent Mesoderm from Pluripotent Stem Cells and Temporally Controls Cardiac versus Somite Lineage Diversification.

Taketaro Sadahiro, Mari Isomi, Naoto Muraoka, Hidenori Kojima, Sho Haginiwa, Shota Kurotsu, Fumiya Tamura, Hidenori Tani, Shugo Tohyama, Jun Fujita, Hiroyuki Miyoshi, Yoshifumi Kawamura, Naoki Goshima, Yuka W Iwasaki, Kensaku Murano, Kuniaki Saito, Mayumi Oda, Peter Andersen, Chulan Kwon, Hideki Uosaki, Hirofumi Nishizono, Keiichi Fukuda, Masaki Ieda

Cell stem cell, 23(3) 382-395, Sep 6, 2018 Peer-reviewed
Direct In Vivo Reprogramming with Sendai Virus Vectors Improves Cardiac Function after Myocardial Infarction.

Kazutaka Miyamoto, Mizuha Akiyama, Fumiya Tamura, Mari Isomi, Hiroyuki Yamakawa, Taketaro Sadahiro, Naoto Muraoka, Hidenori Kojima, Sho Haginiwa, Shota Kurotsu, Hidenori Tani, Li Wang, Li Qian, Makoto Inoue, Yoshinori Ide, Junko Kurokawa, Tsunehisa Yamamoto, Tomohisa Seki, Ryo Aeba, Hiroyuki Yamagishi, Keiichi Fukuda, Masaki Ieda

Cell stem cell, 22(1) 91-103, Jan 4, 2018 Peer-reviewed
Distinct expression patterns of Flk1 and Flt1 in the coronary vascular system during development and after myocardial infarction

Shota Kurotsu, Rina Osakabe, Mari Isomi, Fumiya Tamura, Taketaro Sadahiro, Naoto Muraoka, Hidenori Kojima, Sho Haginiwa, Hidenori Tani, Kaori Nara, Yoshiaki Kubota, Masatsugu Ema, Keiichi Fukuda, Takeshi Suzuki, Masaki Ieda

Biochemical and Biophysical Research Communications, 495(1) 884-891, Jan 1, 2018 Peer-reviewed
Single-Construct Polycistronic Doxycycline-Inducible Vectors Improve Direct Cardiac Reprogramming and Can Be Used to Identify the Critical Timing of Transgene Expression

Tomohiko C. Umei, Hiroyuki Yamakawa, Naoto Muraoka, Taketaro Sadahiro, Mari Isomi, Sho Haginiwa, Hidenori Kojima, Shota Kurotsu, Fumiya Tamura, Rina Osakabe, Hidenori Tani, Kaori Nara, Hiroyuki Miyoshi, Keiichi Fukuda, Masaki Ieda

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 18(8), Aug, 2017 Peer-reviewed
Discovery and progress of direct cardiac reprogramming

Hidenori Kojima, Masaki Ieda

CELLULAR AND MOLECULAR LIFE SCIENCES, 74(12) 2203-2215, Jun, 2017 Peer-reviewed
Fibroblast Growth Factors and Vascular Endothelial Growth Factor Promote Cardiac Reprogramming under Defined Conditions

Hiroyuki Yamakawa, Naoto Muraoka, Kazutaka Miyamoto, Taketaro Sadahiro, Mari Isomi, Sho Haginiwa, Hidenori Kojima, Tomohiko Umei, Mizuha Akiyama, Yuki Kuishi, Junko Kurokawa, Tetsushi Furukawa, Keiichi Fukuda, Masaki Ieda

STEM CELL REPORTS, 5(6) 1128-1142, Dec, 2015 Peer-reviewed

Misc.

冠動脈におけるFlk1およびFlt1発現は心筋梗塞発症中と発症後に特異的に制御される(Flk1 and Flt1 Expression in Coronary Vessels are Differentially Regulated during Development and after Myocardial Infarction)

刑部里奈, 黒津祥太, 村岡直人, 貞廣威太郎, 礒見まり, 萩庭頌, 児島秀典, 田村文弥, 谷英典, 奈良香織, 鈴木岳之, 家田真樹

日本循環器学会学術集会抄録集, 82回 OJ22-4, Mar, 2018
小分子によって高度に増強される心筋リプログラミング(Highly Enhanced Cardiac Reprogramming by Small Molecule)

村岡直人, 奈良香織, 山川裕之, 宮本和享, 貞廣威太郎, 児島秀典, 萩庭頌, 谷英典, 黒津祥太, 田村文弥, 刑部里奈, 家田真樹

日本循環器学会学術集会抄録集, 82回 PJ011-5, Mar, 2018
Flk1 and Flt1 Expression in Coronary Vessels are Differentially Regulated during Development and after Myocardial Infarction(和訳中)

刑部里奈, 黒津祥太, 村岡直人, 貞廣威太郎, 礒見まり, 萩庭頌, 児島秀典, 田村文弥, 谷英典, 奈良香織, 鈴木岳之, 家田真樹

日本循環器学会学術集会抄録集, 82回 OJ22-4, Mar, 2018
Highly Enhanced Cardiac Reprogramming by Small Molecule(和訳中)

村岡直人, 奈良香織, 山川裕之, 宮本和享, 貞廣威太郎, 児島秀典, 萩庭頌, 谷英典, 黒津祥太, 田村文弥, 刑部里奈, 家田真樹

日本循環器学会学術集会抄録集, 82回 PJ011-5, Mar, 2018
センダイウイルスベクターを用いる有効かつ安全な心臓の再プログラミング(Efficient and Safe Cardiac Reprogramming Using Sendai Viral Vectors)

宮本和享, 村岡直人, 貞廣威太郎, 児島秀典, 礒見まり, 秋山瑞葉, 黒津祥太, 福田恵一, 家田真樹

日本循環器学会学術集会抄録集, 81回 PJ-527, Mar, 2017
慢性心不全の診断と治療―最近の動向心筋再生医療に迫る―最前線の心筋細胞再生とは―

児島秀典, 家田真樹

カレントテラピー, 33(12) 1208-1214, Dec, 2015
Rapid And Robust Reprogramming Of Fibroblasts Into Integration-free Functional Cardiomyocytes With Sendai Viral Vectors

Kazutaka Miyamoto, Hiroyuki Y. Amakawa, Naoto Muraoka, Taketaro Sadahiro, Hidenori Kojima, Sho Haginiwa, Mari Isomi, Yuki Kuishi, Shintaro Ninomiya, Keiichi Fukuda, Masaki Ieda

CIRCULATION, 132, Nov, 2015
In Vivo Cardiac Reprogramming by a Single Polycistronic Vector Improves Cardiac Function after Myocardial Infarction

Yuki Kuishi, Mizuha Akiyama, Naoto Muraoka, Kazutaka Miyamoto, Taketaro Sadahiro, Mari Isomi, Hidenori Kojima, Sho Haginiwa, Keiichi Fukuda, Masaki Ieda

JOURNAL OF CARDIAC FAILURE, 21(10) S189-S189, Oct, 2015
Cardiac Reprogramming into Ventricular-type Myocytes by Transduction of Seven Transcription Factors

Mari Isomi, Naoto Muraoka, Kazutaka Miyamoto, Taketaro Sadahiro, Hidenori Kojima, Sho Haginiwa, Mizuha Akiyama, Yuki Kuishi, Keiichi Fukuda, Masaki Ieda

JOURNAL OF CARDIAC FAILURE, 21(10) S189-S189, Oct, 2015
薬物負荷下FFRにて有意な狭窄が証明された、運動極期に心室細動を発症した右冠動脈起始異常の1例

樫村晋, 西山信大, 児島秀典, 中嶋一晶, 八島史明, 國富晃, 勝俣良紀, 西山崇比古, 木村雄弘, 谷本陽子, 相澤義泰, 前川裕一郎, 福田恵一, 高月誠司

心臓, 47(Suppl.1) 93-97, Aug, 2015
貧血によるリウマチ性連合弁膜症の心不全を初発症状とし,Gastric antral vascular ectasiaからの繰り返す出血に対してエストロゲン‐プロゲステロン療法が奏功,のちに強皮症が疑われた1例

児島秀典, 柴田勝, 塩崎裕士, 舘桂一郎, 宮澤正治, 松川英彦, 森谷和徳, 小山卓史, 柏崎一男, 三田村秀雄

日本内科学会関東支部関東地方会, 603rd 82, 2014
重症急性膵炎に合併した後天性血友病の1例

児島秀典, 清水智樹, 今井仁, 今村諭, 角田裕也, 伊藤剛, 長久保秀一, 諸星雄一, 藤田由里子, 小松弘一

日本内科学会関東支部関東地方会, 585th 57, 2012

Research Projects

遺伝性心疾患治療のための心筋ダイレクトリプログラミングの開発

未成年心臓血管病の学究等に対する奨励金, 公益財団法人宮田心臓病研究振興基金

児島秀典

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