2016年
Non-enzymatic reaction of glycosyl oxazoline with peptides
Carbohydrate Research
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- 巻
- 436
- 号
- 開始ページ
- 31
- 終了ページ
- 35
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.carres.2016.11.002
- 出版者・発行元
- ELSEVIER SCI LTD
© 2016 Elsevier Ltd Recently, a number of chemoenzymatic strategies have been explored for achieving preparation of homogeneous glycopeptides and glycoproteins, especially by using endoglycanases and glycosyl oxazolines. However, concomitant occurrence of non-enzymatic reactions has been reported, but no further characterization of the byproducts was conducted. In this work, we made an attempt to identify the side product by using model substrates. Analysis of the product allowed us to propose that the oxazoline ring was attacked by the amino group of lysine, leading to the formation of disubstituted acetamidine.
- リンク情報
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- DOI
- https://doi.org/10.1016/j.carres.2016.11.002
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/27846428
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000389516000005&DestApp=WOS_CPL
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84995546081&origin=inward 本文へのリンクあり
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84995546081&origin=inward
- ID情報
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- DOI : 10.1016/j.carres.2016.11.002
- ISSN : 0008-6215
- eISSN : 1873-426X
- PubMed ID : 27846428
- SCOPUS ID : 84995546081
- Web of Science ID : WOS:000389516000005