1994年7月
NEURITE OUTGROWTH OF PC12 CELLS IS SUPPRESSED BY WORTMANNIN, A SPECIFIC INHIBITOR OF PHOSPHATIDYLINOSITOL 3-KINASE
JOURNAL OF BIOLOGICAL CHEMISTRY
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- 巻
- 269
- 号
- 29
- 開始ページ
- 18961
- 終了ページ
- 18967
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- 出版者・発行元
- AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
The effects of wortmannin (WT), an inhibitor of phosphatidylinositol (PI) 3-kinase, on differentiation of PC12 cells were analyzed. WT inhibited PI 3-kinase activity of PC12 cells at a concentration of 10(-7) M in vivo and in vitro. Transient inhibition of PI 3-kinase activity at the time of nerve growth factor stimulation had no effect on activation of the ras protein or neurite formation by the cells. However, continuous inhibition of PI 3-kinase blocked differentiation at the step just before neurite formation. When WT was applied to cells growing neurites, elongation of the neurites was stopped at that step. These results suggest that PI 3-kinase may be involved in neurite elongation.
- リンク情報
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- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:A1994NX32700041&DestApp=WOS_CPL
- URL
- http://www.scopus.com/inward/record.url?eid=2-s2.0-0028242353&partnerID=MN8TOARS
- URL
- http://orcid.org/0000-0002-3359-1578
- ID情報
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- ISSN : 0021-9258
- ORCIDのPut Code : 20897395
- SCOPUS ID : 0028242353
- Web of Science ID : WOS:A1994NX32700041